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Combined display of all available logs of haematologyetc.co.uk. You can narrow down the view by selecting a log type, the username (case-sensitive), or the affected page (also case-sensitive).
- 21:05, 12 May 2023 John talk contribs created page CD23 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span> <span style="font-...")
- 20:32, 11 May 2023 John talk contribs created page CD4 & CD8 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :'''Systemic disease:''' On T lymphocytes these two co-stimulatory molecules define different functional types; an altered ratio between CD4 and CD8 cells can indicate systemic disease or immune dysfunction :'''Neoplasia:''' Expanded populations of CD4 or CD8 cells (or T cells with unusual expression patterns of these molecules) may represent a malignant clone, and the CD4...")
- 15:53, 10 May 2023 John talk contribs created page CD61 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
- 15:53, 10 May 2023 John talk contribs created page CD43 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
- 15:52, 10 May 2023 John talk contribs created page CD41 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
- 12:43, 9 May 2023 John talk contribs created page CD22 (Created page with "CD22 expression is largely restricted to b cell lineage and expression is acquired at an early differentiation stage. *expression varies during mature b-cell development however the major value of CD22 lies in the identification of all based on high lineage-specificity and very early acquisition allowing the identification of pro-b all. normal expression and function CD22 is a membrane receptor that binds sialic acid containing glycans and expression is mostly rest...")
- 23:16, 8 May 2023 John talk contribs created page CD1a (Created page with "A T cell marker that has value in specific circumstances Background CD1a is structurally related to major histocompatibility complex proteins and is thought to mediate the presentation of lipid and glycolipid antigens. CD1a expression is absent on very early thymocytes, but is acquired together with CD4 and CD8 as T cells develop in the thymus, then is lost in mature T cells. Diagnostic Use :A marker of early T-lineage :CD1A us useful in the identification of some cas...")
- 21:58, 8 May 2023 John talk contribs created page CD19 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span> <span style="font-...")
- 13:23, 7 May 2023 John talk contribs created page CD10 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD10 is expressed early pre-B ALL ("common ALL"), but also has wide expression on all subtypes notably also being expressed by Burkitt lymphoma and many cases of T-ALL :CD10 is also found on normal developing B-lymphocytes (haematogones) so is found very frequently in regenerating marrows :In mature lymphoproliferative...")
- 14:13, 6 May 2023 John talk contribs created page CD2 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD2 is a pan t-cell marker. In diagnostic use it may be less reliable than CD3 for identification of T-cell lineage, since loss of CD2 expression is seen in some peripheral T-cell lymphomas, and aberrant expression in AML is recognised (particularly the APL subtype). </div> <span style="color:navy">'''Normal expressi...")
- 12:44, 6 May 2023 John talk contribs created page Extra (Created page with "CD14 aids recognition of bacteria by cells of monocytic lineage. it may generally be regarded as a pan-monocyte antigen when expressed in aml CD14 is a marker of monocytic lineage absence of CD14 expression does not preclude monocytic lineage since some typical monoblasts do not express this marker CD14 is not restricted to malignant cells and will be expressed by reactive monocytes and also by neoplastic cells of cmml normal expression and function together...")
- 11:59, 6 May 2023 John talk contribs created page CD14 (Created page with "(259, 'cd14', ' cd14 aids recognition ofu800 bacteria byu800 cells ofu800 monocytic lineage. itu800 mayu800 generally beu800 regarded asu800 au800 panu800-monocyte antigen * when expressed inu800 amlu800 cd14 isu800 au800 marker ofu800 monocytic lineage * absence ofu800 cd14 expression does notu800 preclude monocytic lineage since some typical monoblasts dou800 notu800 express this marker * cd14 isu800 notu800 restricted tou800 malignant cells andu800 will beu800 express...")
- 22:57, 3 May 2023 John talk contribs created page CD79a (Created page with "<span style="color:navy">'''''DETAILS'''''</span> CD38 helps mobilise intracellular calcium to activate a wide array of cell functions. In haematological cell types CD38 it is widely expressed by lymphoid cells )B, T and NK) as well as myeloid precursor cells and mature myeloid cells. It has particular diagnostic importance for lymphocytes where CD38 expression is acquired as stem cells commit to B-cell lineage, then is lost as mature B cells emerge from bone marrow be...")
- 14:10, 3 May 2023 John talk contribs created page Key to marker expression table (Created page with " <span style="font-size:80%">'''''1. Colour key:''''' ''- the likelihood of any individual case expressing this marker, indicated by colour:'' </span> {| class=wikitable style="text-align: left; font-size:80%; width: 60%; height: 30px; |style= "width: 16.6%; background: #FFE4E1; |Few reported studies (though likely rare) |} {| class=wikitable style="text-align: left; font-size:80%; width:60%; height: 30px; |style= "width: 16.6%; background: #E6FAFF; |Expression may b...")
- 15:28, 1 May 2023 John talk contribs created page CD4 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :'''Systemic disease:''' On T lymphocytes these two co-stimulatory molecules define different functional types; an altered ratio between CD4 and CD8 cells can indicate systemic disease or immune dysfunction :'''Neoplasia:''' Expanded populations of CD4 or CD8 cells (or T cells with unusual expression patterns of these molecules) may represent a malignant clone, and the CD4...")
- 10:21, 1 May 2023 John talk contribs created page CD11c (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span>")
- 20:51, 30 April 2023 John talk contribs created page CD3 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span>")
- 17:10, 30 April 2023 John talk contribs created page CD5 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :'''For mature B cell neoplasms''': CD5 is used to indicate likely CLL or MCL. However, expression is present on a subset of normal B cells, and also less frequently on other lymphoma types. Full interpretation therefore requires consideration of clonality and other markers. :'''In acute lymphoblastic leukaemia''': CD5 is u...")
- 10:24, 30 April 2023 John talk contribs created page CD45 (Created page with "<span style="color:navy">'''''SUMMARY TABLES'''''</span> {| class=wikitable style="text-align: center; font-size:80%; width: 100%; height 20px;" |- !colspan="7"|<span style="font-size:100%">'''CD13 expression: primitive cell types'''</font> |- ! AML !! B ALL !! Burkitt || T ALL !! ETP ALL ('''i''') !! MPAL '''i || Hgns '''i''' |- |style="width: 14.25%; background: #FFE4E1 #FFE4E1 #66e0ff #00b8e6 #006699; color:white"|Limited Rare Possible...")
- 13:46, 26 April 2023 John talk contribs created page CD38 (Created page with " <span style="color:navy">'''''DETAILS'''''</span> CD38 helps initiate the mobilsation of intracellular calcium, activating a wide array of cell functions that depend on cell type. In haematological cell types CD38 is widely expressed by lymphoid cells and by particular myeloid cells – often in a stage-specific manner. For B lymphocytes CD38 expression is acquired as stem cells commit to B-cell lineage, then lost as mature B cells emerge from bone marrow before be...")
- 12:50, 26 April 2023 John talk contribs created page CD13 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> *The principle diagnostic value of CD38 is that its expression is retained and generally increased during differentiation to plasma cells *CD38 expression has some value in predicting prognosis in CLL *CD38 is also expressed by committed stem cells together with CD34 and can occasionally be of value in acute leukaemia diagnosis </div> <span style="color:navy">'''Norma...")
- 12:36, 26 April 2023 John talk contribs created page Flow Cytometry (Created page with " <span style="color:navy>1. ''Markers used mainly for gating:''</span> {|style="width: 80px; height: 80px; text-align:center; font-style: bold; font-size: 120%; color: teal; background: #ededed; border-style: solid; border-width: 2px" | <span style="color:teal">'''CD45'''</span> |} ---- <span style="color:navy>2. ''Non CD-classified markers''</span> {|style="float:left; width: 80px; height: 80px; text-align:center; font-style: bold; color: maroon; back...")
- 16:50, 23 April 2023 John talk contribs created page Ex-flagellation (Created page with "<span style="color:navy>'''Description'''</span> The male and female gametocytes of the malarial parasite may continue to mature in stored blood, in particular the pH change and temperature change may resemble changes normally encountered in the mosquito stomach, where the male gametocyte releases the microgametes as part of sexual replication. This process can be detected in some stored cases. ---- Early trophozoites: <gallery mode="nolines" widths="220px" heights...")
- 16:27, 23 April 2023 John talk contribs created page Ring forms (Created page with " ---- '''What is a ring form''' <gallery mode="nolines" widths="220px" heights="220px" > File:Ring_cartoon.jpg|link={{filepath:|MFETr.jpg}} </gallery> The earliest stage following red cell invasion has a typical ting form: *a = chromatin dot *b = digestive vacuole *c = parasite cytoplasm ---- <span style="color:navy>'''Description'''</span> At the earliest stage of red cell infection parasites have a ring form and distinction between species may not be easy (or ev...")
- 16:10, 23 April 2023 John talk contribs created page Distrorted erythrocyte shape (Created page with " ---- <gallery mode="nolines" widths="220px" heights="220px" > File:MDi1.jpg|: ''P.vivax''|link={{filepath:MDi1.jpg}} </gallery> <span style="color:navy>'''Description'''</span> Distortion of the erythrocyte shape is one of the modifications caused by parasite invasion. The most substantial distortion is caused by ''P.vivax'' in which the red cells become both enlarged and irregular in shape. <span style="color:navy>'''Species significance'''</span> Marked red...")
- 16:08, 23 April 2023 John talk contribs created page Phagocytosed malaria pigment (Created page with " ---- '''Appearance:''' In the context of malarial infection the neutrophils may contain masses of phagocytosed brown or golden malaria pigment within their cytoplasm. ---- '''Images of malaria pigment''' <gallery mode="nolines" widths="270px" heights="300px" > File:Mp1.jpg|link= File:Mp2.jpg|link= File:Mp3.jpg|link= </gallery> <span style="font-size:85%"> ''Images of neutrophils containing malaria pigment: Image 1 shows a schizont in the process of releasing daug...")
- 16:06, 23 April 2023 John talk contribs created page Malaria pigment (Created page with " ---- <gallery mode="nolines" widths="220px" heights="220px" > File:MPi1.jpg|: ''P.malariae'' with golden pigment over the parasite surface|link={{filepath:MPi1.jpg}} </gallery> <span style="color:navy>'''Description'''</span> During their development malarial parasites metabolise the haemoglobin within erythrocytes to support their growth - hence infected cells become "ghost cells" devoid of visible haemoglobin at later stages of parasite development. As part of th...")
- 16:01, 23 April 2023 John talk contribs created page Schüffner's dots (Created page with " ---- <gallery mode="nolines" widths="220px" heights="220px" > File:MSc1.jpg|link={{filepath:MSc1.jpg}} File:MSc2.jpg|link={{filepath:MSc2.jpg}} File:MSc3.jpg|link={{filepath:MSc3.jpg}} File:MSc4.jpg|link={{filepath:MSc4.jpg}} </gallery> Different intensities of cytoplasmic dots, from faint to intense during the development of ''P.vivax''. Note that even when faint the number of dots is high (compare with the Maurer's dots and clefts of ''P.falciparum'') <span style...")
- 15:58, 23 April 2023 John talk contribs created page Band appearance (Created page with " ---- <gallery mode="nolines" widths="220px" heights="220px" > File:MBa3.jpg|: ''P.malarae'' mature band|link={{filepath:MBa3.jpg}} File:Mba3.jpg|: ''P.malarae'' early band|link={{filepath:MBa3.jpg}} File:MBa2.jpg|: ''P.malarae'' mature band|link={{filepath:MBa2.jpg}} </gallery> <span style="color:navy>'''Description'''</span> An early or late trophozoite form that is very elongated and extends close to, or entirely across, the diameter of the erythocyte <span s...")
- 14:30, 23 April 2023 John talk contribs created page Banana gametocyte (Created page with " ---- <gallery mode="nolines" widths="220px" heights="220px" > File:MB1.jpg|: ''P.falciparum'' macrogametocyte|link={{filepath:MB1.jpg}} File:MB2.jpg|: ''P.falciparum microgametocyte''|link={{filepath:MB2.jpg}} </gallery> <span style="color:navy>'''Description'''</span> The gametocyte stage of ''P.falciparum'' has the form of a round-ended rod. The rod is slightly longer than a red cell so becomes curved by the red cell membrane and is often described a "banana shap...")
- 14:29, 23 April 2023 John talk contribs created page Amoeboid forms (Created page with " ---- <gallery mode="nolines" widths="220px" heights="220px" > File:MAm2.jpg|: ''P.vivax''|link={{filepath:MAm2.jpg}} </gallery> <span style="color:navy>'''Description'''</span> The late trophozoite of ''P.vivax'' becomes more solid, but with an irregular form that is said to resemble an amoeba with extended processes. Other features of the species will also be detected. <span style="color:navy>'''Species significance'''</span> A fairly specific feature of ''P...")
- 14:19, 23 April 2023 John talk contribs created page Forms Main Menu (Created page with "---- <gallery mode="nolines" widths="300px" heights="260px" > File:Blood_stages_1.jpg|link={{filepath:MAm3.jpg}} </gallery> '''INDEX''' ---- '''A''' Accolé form - the "edge" parasite, most closely associated with ''P.falcparum'' though certainly not restricted to this species Amoeboid forms - a particular description applied to the irregular solid late trophozoites from ''P.vivax'', very typical of the species Angular forms - a solid late trophoz...")
- 14:17, 23 April 2023 John talk contribs created page Species Main Menu (Created page with " ---- '''''Plasmodium falciparum''''' right|400px|link= '''Brief Summary''' *Small fine ring forms with certain characteristic features *Rings have relatively uniform appearance *Maurer's dots and clefts in late trophozoites *Schizonts very rarely seen *Characteristic elongated (often curved) 'banana' gametocyes '''More''' click for full description click for gallery of forms ----...")
- 14:12, 23 April 2023 John talk contribs created page Malaria Index (Created page with " ---- '''''Plasmodium falciparum''''' right|400px|link= '''Brief Summary''' *Small fine ring forms with certain characteristic features *Rings have relatively uniform appearance *Maurer's dots and clefts in late trophozoites *Schizonts very rarely seen *Characteristic elongated (often curved) 'banana' gametocyes '''More''' click for full description click for gallery of forms ----...")
- 13:36, 29 March 2023 John talk contribs created page File:RedCellsBack.png
- 13:36, 29 March 2023 John talk contribs uploaded File:RedCellsBack.png
- 13:32, 29 March 2023 John talk contribs created page Main Page/new (Created page with " ------ <span style="color: navy> '''Thank you for visiting HaematologyETC''' </span> we are now getting fixed slowly! <gallery mode="nolines" widths="240px" heights="240px" border="1px" > File:getting_fixed.jpg|link={{filepath:getting_fixed.jpg}}}} </gallery> We are uploading the original pages and hope to have some working content soon! Please re-visit for updates, Thanks for visiting '''John Burthem''' and '''Michelle Brereton''' ------ ---- Red Cell Me...")
- 22:10, 28 March 2023 John talk contribs created page Red Cell Menu (Created page with " ------ <span style="color: navy> '''Thank you for visiting HaematologyETC''' </span> we are now getting fixed slowly! <gallery mode="nolines" widths="240px" heights="240px" border="1px" > File:getting_fixed.jpg|link={{filepath:getting_fixed.jpg}}}} </gallery> We are uploading the original pages and hope to have some working content soon! Please re-visit for updates, Thanks for visiting '''John Burthem''' and '''Michelle Brereton''' ------ ---- test te...")
- 22:07, 28 March 2023 John talk contribs created page File:PH2A.jpg
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- 17:46, 27 March 2023 John talk contribs created page File:Crys0.png
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- 17:31, 27 March 2023 John talk contribs created page File:Crys1A.png
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- 14:27, 27 March 2023 John talk contribs created page File:Ova1A.png
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- 11:17, 27 March 2023 John talk contribs created page Alphabetical list of red cell forms (Created page with " ---- A :Agglutination :Anisochromia :Anisocytosis :Acanthocytes ---- B :Basophilic stippling :Bite cells (keratocytes) :Blister cells (hemighosts) :Boat-shaped cells :Burr cells (echinocytes} ---- C :Codocytes (target cells) :Cabot rings ---- D :Dacrocytes (teardrop cells} :Dimorphic :Drepanocytes (sickle cells) ---- E :Echinocytes...")
- 10:57, 27 March 2023 John talk contribs created page File:Pen1A.png
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- 10:49, 27 March 2023 John talk contribs created page File:Ova0.png
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- 10:39, 27 March 2023 John talk contribs created page File:MSp0A.png
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- 23:33, 26 March 2023 John talk contribs created page File:SP2A.jpg
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- 23:01, 26 March 2023 John talk contribs created page File:Boat2A.png
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- 22:03, 26 March 2023 John talk contribs created page File:IRC1A.png
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- 21:40, 26 March 2023 John talk contribs created page File:SCP0.png
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- 21:32, 26 March 2023 John talk contribs created page File:TD2A.jpg
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- 19:34, 26 March 2023 John talk contribs created page File:TD1A.png
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- 19:08, 26 March 2023 John talk contribs uploaded a new version of File:DM2A.jpg
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- 18:57, 26 March 2023 John talk contribs created page File:PolyC1A.png
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- 19:38, 24 March 2023 John talk contribs created page File:NRBC1C.png
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- 11:28, 24 March 2023 John talk contribs created page File:SC1A.png
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- 23:23, 23 March 2023 John talk contribs created page Alphabetical list red cell forms (Created page with " ---- A :Agglutination :Anisochromia :Anisocytosis :Acanthocytes ---- B :Basophilic stippling :Bite cells (keratocytes) :Blister cells (hemighosts) :Boat-shaped cells :Burr cells (echinocytes} ---- C :Codocytes (target cells) :Cabot rings ---- D :Dacrocytes (teardrop cells} :Dimorphic :Drepanocytes (sickle cells) ---- E :Echinocytes...")
- 19:11, 23 March 2023 John talk contribs created page File:Rou0.png
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- 19:06, 23 March 2023 John talk contribs created page File:HypoC0a.png
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- 19:01, 23 March 2023 John talk contribs created page File:PolyC0.png
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- 18:57, 23 March 2023 John talk contribs created page File:Nrbc0.png
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- 18:44, 23 March 2023 John talk contribs created page File:Aniso0.png
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- 16:36, 23 March 2023 John talk contribs created page Test1 (Created page with " ---- <span style="color:navy">''Click on the image to go to the page''</span> '''1. Terms applied to groups of red cells''' ---- <gallery mode="nolines" widths="140px" heights="140px" > File:Aggs.png|''Agglutination''|link=Agglutination File:Rouleaux.png|''Rouleaux''|link=Rouleaux File:Dimorphic.png|''Dimorphic''|link=Dimorphic </gallery> '''2. Circulating erythrocytes from early stages of maturation''' ---- <gallery mode="nolines" widths="140px" heights="140p...")
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- 17:32, 6 March 2023 John talk contribs created page File:Getting fixed.jpg
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- 16:13, 6 March 2023 John talk contribs created page File:Anisocytosis 2.jpg
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- 16:12, 6 March 2023 John talk contribs created page File:RC F anisocytosis G.jpg
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- 16:12, 6 March 2023 John talk contribs created page File:RC C anisocytosis G.jpg
- 16:12, 6 March 2023 John talk contribs uploaded File:RC C anisocytosis G.jpg
- 15:54, 6 March 2023 John talk contribs created page Anisocytosis (Created page with " '''Derivation:''' ''From the Greek Aniso (unequal) and Greek Chromia (referring to colour or shade)'' ---- '''Description''' This is a simple term that describes variation of colour between the red cells on blood smears; the term does not imply the nature of that variation or a pathological cause – just that different red cell have a different shade! <gallery mode="nolines" widths="240px" heights="240px" border="1px" > File:RC_C_anisochromia_G.png|link={{fi...")
- 13:57, 6 March 2023 John talk contribs created page File:Anisochromia 2.jpg
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- 13:48, 6 March 2023 John talk contribs created page File:RC C anisochromia G.png
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- 13:43, 6 March 2023 John talk contribs created page File:RC F anisochromia G.jpg
- 13:43, 6 March 2023 John talk contribs uploaded File:RC F anisochromia G.jpg
- 13:27, 6 March 2023 John talk contribs created page Anisochromia (Created page with " '''Derivation:''' ''From latin “fasten with glue”'' ---- '''Description''' Erythrocytes linked together to form irregular clumps of varying size. <gallery mode="nolines" widths="240px" heights="240px" border="1px" > File:RC_C_agglutination_G.png|link={{filepath:RC_C_agglutination_G.png}} File:RC_F_Agglutination_G.jpg|link={{filepath:RC_F_agglutination_G.jpg}} </gallery> <span style="font-style:italic; font-size:90%;'' > '''Appearance:''' The key points a...")
- 13:09, 3 March 2023 John talk contribs created page Boat-shaped cells (Created page with "(14170, '__NOTOC__nnnDerivation: Derivation: ''descriptive term derived from resemblance to a canoe viewed from above (or a pair of lips)''nnnnn' ''AppearancennnAn elliptical cell with sharpened ends and an elongated and sharpened area of central pallor; the cells are broader than a typical sickle cell and lack the characteristic curve.nnngallery widths="180px " heights="180px" nFile:BC2.png|link={{filepath:BC2.png}}ngallerynnnspan style="fontsize:90%"n' ' Image 1 Bo...")
- 16:19, 27 February 2023 John talk contribs created page Understanding red cell morphology - a short guide (Created page with "NOTE Use existing red cell biconcave disk, with the following accompanying text: The function of red cell is to safely transport haemoglobin between lungs and tissues. This function requires the different elements of red cell structure to work together. Each of these elements may be affected by inherited or acquired disease - each in turn can cause abnormal morphological appearances. NOTE Now we have these pieces of text that ideally act as buttons or have attached butto...")
- 16:13, 27 February 2023 John talk contribs created page File:Ac6.jpg
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- 10:52, 21 February 2023 John talk contribs created page Test2 (Created page with " ---- <gallery widths="100px" heights="70px" > File:nASLX1.png||link=ASXL1| File:nBCOR.png||link=BCOR| File:nCALR.png||link=CALR| File:nCBL.png||link=CBL| File:nCEBPA.png||link=CEBPA| File:nCHEK2.png||link=CHEK2| File:nCSF3R.png||link=CSF3R| File:nCUX1.png||link=CUX1| File:nDNNT3A.png||link=DNMT3A| File:nEZH2.png||link=EZH2| File:nETV6.png||link=ETV6| File:nFLT3.png||link=FLT3| File:nGATA1.png||link=GATA1| File:nGATA2.png||link=GATA2| File:nHRAS.png||link=HRAS| File:nI...")
- 23:11, 20 February 2023 John talk contribs created page File:Agglutination3.jpg
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- 23:11, 20 February 2023 John talk contribs uploaded File:Agglutination2.jpg
- 23:11, 20 February 2023 John talk contribs created page File:Agglutination1.jpg
- 23:11, 20 February 2023 John talk contribs uploaded File:Agglutination1.jpg
- 22:10, 20 February 2023 John talk contribs created page File:RC F Agglutination G.jpg
- 22:10, 20 February 2023 John talk contribs uploaded File:RC F Agglutination G.jpg
- 17:28, 20 February 2023 John talk contribs created page File:RC C agglutination G.png
- 17:28, 20 February 2023 John talk contribs uploaded File:RC C agglutination G.png
- 21:24, 19 February 2023 John talk contribs created page Target cells (Created page with " '''Derivation:''' ''cells resemble targets with a central “bulls eye” ---- '''Appearance''' Erythrocytes in which the area of pallor contains a central accumulation of haemoglobin giving the appearance of a "target". <span style="font-size:90%"><span style="color:#808080"> <gallery widths="180px" heights="180px" > File:Tg1.png|1:Target cell File:Tg2.png|200px|2: Target cells (context) </gallery> <span style="font-size:90%"><span style="color:#808080"> '''I...")
- 21:21, 19 February 2023 John talk contribs created page Stomatocytes (Created page with " '''Derivation:''' ''Stoma (zoology) “a mouth like opening”Stoma (zoology) “a mouth like opening”'' ---- '''Appearance''' The area of central pallor has the form of a “slit” or “mouth”. Depending on the cause, the cells may be enlarged or have ovoid shape. <gallery widths="180px" heights="180px" > File:St1.png|link={{filepath:St1.png}} </gallery> '''Image 1:''' <div class="toccolours mw-collapsible mw-collapsed" style="font-size 80%; overflow...")
- 21:16, 19 February 2023 John talk contribs created page Teardrop cells (Created page with "__NOTOC__ '''Derivation:''' ''Descriptive plus Greek poikilos [varied]'' ---- '''Appearance''' The abnormal cells have the shape of a tear drop. <gallery widths="180px" heights="180px" > File:TD1.png| </gallery> '''Image 1 Tear drop cell''' <div class="toccolours mw-collapsible mw-collapsed" style="font-size 80%; overflow:auto;"> The classic form – sometimes described as having a “pinched top” but the resemblance to a tear drop is probably the best descr...")
- 21:15, 19 February 2023 John talk contribs created page Spherocytes (Created page with " '''Derivation:''' ''From the Greek [sphere]'' ---- '''Appearance''' The typical spherocyte is dense and round, lacking central pallor and appearing smaller than normal erythrocytes. They do not generally appear irregular, but may do so if other pathology is present (e.g. post-splenectomy). However, since the spherical form is the end of a what is often a progressive process, cells of intermediate appearance between biconcave disc and true sphere may be found. <g...")
- 21:09, 19 February 2023 John talk contribs created page Sickle cells (Created page with " ---- Also known as: drepanocytes [drepanon = sickle] '''Derivation:''' ''Derivation: descriptive – shaped like the farming tool “sickle”'' ---- '''Appearance''' The abnormal cells are very elongated and crescent shaped with dense bodies and characteristic sharp-ends. <gallery widths="180px" heights="180px" > File:SCD2.png|link={{filepath:SCD2.png}} </gallery> <span style="font-size:90%"><span style="color:#808080"> '''Image 1''' Sickle cells: The appea...")
- 21:05, 19 February 2023 John talk contribs created page Fragmented cells (Created page with " (schistocytes) '''Derivation:''' ''“schistos” [divided]'' ---- '''Appearance''' Irregularly shaped red cell fragments, often applied to cells that are asymmetrical with sharp projections; more rounded fragments may have a different significance. <gallery widths="180px" heights="180px" > File:Fr1a.png|link={{filepath:Fr1a.png}} </gallery> <span style="font-size:90%"> '''''Image 1''' These are the sharp fragmented forms that typically arise from fibrin-she...")
- 19:57, 19 February 2023 John talk contribs created page Ovalocytes (Created page with " '''Derivation:''' '' "macro" signifying large in scale (from Greek: makros) '' ---- '''Appearance.''' Any large erythrocyte is described as macrocytic. If the shape is also affected this may be included in the description e.g. oval macrocyte. Morphologically, large size can be detected by comparison with a small lymphocyte: an individual erythrocyte should have size similar to the nucleus of a small lymphocyte.'' 180px||link= <span style="f...")
- 19:55, 19 February 2023 John talk contribs created page SC poikilocytes (Created page with "__NOTOC__ '''Derivation:''' ''SC = arising in HbSC disease; poikilocyte = irregularly shaped cell'' ---- '''Appearance''' A dense and often elongated cell that may resemble a poorly formed sickle cell or an unusually shaped poikilocyte, but is characterised particularly by irregular short branches that project from the cell body. <gallery widths="180px" heights="180px" > File:SCP1.png|link={{filepath:SCP1.png}} </gallery> '''Image 1 SC poikilocyte''' <div clas...")
- 19:43, 19 February 2023 John talk contribs created page Echinocytes (Created page with " (Also known as burr cells) '''Derivation:''' ''the Greek echinis [hedgehog] '' ---- '''Appearance''' Mature echinocytes have 10-30 surface projections. These tend to be short, blunt, and are distributed relatively evenly across the cell. The appearances develop over time so there is a spectrum of forms. The cells initially resemble normal erythrocytes with subtle projections, these projections become increasingly clear in the mature echinocyte. Depending on the c...")
- 19:42, 19 February 2023 John talk contribs created page Polychromatic Red Cells (Created page with " ---- '''Derivation:''' ‘’Polychromatic - of two or more or of varying colours’’ ---- '''Appearance''' Erythrocytes with an additional blue-tone in their cytoplasm; the blue may be barely visible or may be marked. Polychromatic erythrocytes are generally larger than normal erythrocytes. <span style="font-size:90%"><span style="color:#808080"> 180px||link= <span style="font-size:90%"> '''''Image1 Polychromatic cell''' T...")
- 19:41, 19 February 2023 John talk contribs created page Pencil cells (Created page with " ---- '''Derivation:''' ''little tail'' ---- '''Appearance''' Long thin cells (roughly speaking they have at length more than 4 times their width); pencil cells are generally hypochromic. The cells have blunt rounded ends and no curvature and should not be confused with sickle cells <span style="font-size:90%"><span style="color:#808080"> <gallery widths="180px" heights="180px" > File:Pen1.png|1: Pencil cell File:Pen2.png|200px|Image 2: Pencil cell context </gall...")
- 19:40, 19 February 2023 John talk contribs created page Rouleaux (Created page with " ''Description''' Long or short columns of “stacked” erythrocytes: the cells form a “cup-like” structure so that each successive cell fits into the concave surface of the cell beneath. <gallery mode="nolines" widths="240px" heights="240px" > File:Rouleaux.png|<span style="font-size:90%; color:navy"></span>|link={{filepath:Rouleaux.png}} File:Rouleaux.jpg|<span style="font-size:90%; color:navy"></span>|link={{filepath:Rouleaux.jpg}} </gallery> <span style=...")
- 22:52, 18 February 2023 John talk contribs created page Pappenheimer Bodies (Created page with "'''Derivation:''' ''Described by Alwin M. Pappenheimer US pathologist 1878-1955'' ---- '''Appearance''' Grey/blue inclusions of varying size, generally small and usually (but not always) near the edge of erythrocytes. Frequently they form clusters of 2 or 3 inclusions. They are darker than Howell Jolly bodies. <gallery widths="180px" heights="180px" > File:PH1.png|link={{filepath:PH2.png}} </gallery> <span style="font-size:90%"> '''''Image 1''' Small numbers (gen...")
- 22:50, 18 February 2023 John talk contribs created page Nucleated Red Cells (nRBC) (Created page with " '''Derivation:''' ''descriptive term – a circulating red cell containing a nucleus'' ---- '''Description''' Circulating erythrocytes with cytoplasmic features of mature or maturing (polychromatic) cells but containing a nucleus. Most commonly these are very late in the development stage, but may include earlier developing red cell forms where recognition can be more challenging (see images). <span style="font-size:90%"><span style="color:#808080"> File:NRBC m...")
- 22:49, 18 February 2023 John talk contribs created page Microspherocytes (Created page with "__NOTOC__ '''Derivation:''' ''sphero – resembling sphere; micro - small'' ---- '''Appearance''' Dense cells showing features of spherocytes, but with very reduced size. Evidence for the mechanism of formation may also be visible (see pathogenesis). <gallery widths="180px" heights="180px" > File:MSp1.png|link={{filepath:MSp1.png}} </gallery> '''''Image 1 Micropherocyte''' <div class="toccolours mw-collapsible mw-collapsed" style="font-size 80%; overflow:auto;"...")
- 22:47, 18 February 2023 John talk contribs created page Macrocytic Red Cells (Created page with " '''Derivation:''' '' "macro" signifying large in scale (from Greek: makros) '' ---- '''Appearance.''' Any large erythrocyte is described as macrocytic. If the shape is also affected this may be included in the description e.g. oval macrocyte. Morphologically, large size can be detected by comparison with a small lymphocyte: an individual erythrocyte should have size similar to the nucleus of a small lymphocyte.'' 180px||link= <span style="...")
- 22:45, 18 February 2023 John talk contribs created page Keratocytes (Created page with "'''Clinical Examples''' <gallery widths="250px" heights="250px" > File:Kt3.jpg|link={{filepath:Kt3.jpg}} </gallery> '''Clinical Image 1''': <div class="toccolours mw-collapsible mw-collapsed" style="font-size 80%; overflow:auto;"> Typical keratocyte forms, most have two horns surrounding a central depression. There are also some echinocytes present. Clinical diagnosis: Oxidative damage and Heinz body removal </div> <gallery widths="250px" heights="250px" > File:Kt4...")
- 12:52, 17 February 2023 John talk contribs created page Irregularly contracted cells (Created page with "__NOTOC__ '''Derivation:''' ''A simple term describing cell shape'' ---- '''Appearance''' Dense cells that have a distorted and often irregular outline; central pallor is generally absent and haemoglobin staining may be irregular within the cell. Most often there is a spectrum of forms present. <gallery widths="180px" heights="180px" > File:IRC1.png|link={{filepath:IRC1.jpng}} </gallery> '''Image 1''': <div class="toccolours mw-collapsible mw-collapsed" style=...")
- 12:51, 17 February 2023 John talk contribs created page Microcytic and Hypochromic Red Cells (Created page with "'''Derivation:''' Eponymous: William Howell (US) and Justin Jolly (Fr) early morphologists studying effects of splenic absence '' ---- '''Appearance''' Small blue/purple fragments generally rounded – their colour and position reflects their origin as retained fragments of the cell nucleus that most often they are single and relatively centrally placed. They have relatively large size compared with other inclusions (usually 0.5-1.0μM in diameter compared with a typi...")
- 12:48, 17 February 2023 John talk contribs created page Howell Jolly bodies (Created page with "'''Derivation:''' Eponymous: William Howell (US) and Justin Jolly (Fr) early morphologists studying effects of splenic absence '' ---- '''Appearance''' Small blue/purple fragments generally rounded – their colour and position reflects their origin as retained fragments of the cell nucleus that most often they are single and relatively centrally placed. They have relatively large size compared with other inclusions (usually 0.5-1.0μM in diameter compared with a typi...")
- 12:47, 17 February 2023 John talk contribs created page Hemighost cells (Created page with "AKA Blister cells '''Derivation:''' ''From ancient Greek: prefix hemi (half); and descriptive term ghost cell: an empty cell whose outline remains visible'' ---- '''Appearance''' Cells where the haemoglobin is contracted to one pole of the cell leaving a visible empty area at the opposite pole surrounded by membrane (giving a characteristic “blister” appearance). In some cases, the haemoglobin may be entirely absent from the cell (ghost cell). <gallery widt...")
- 12:45, 17 February 2023 John talk contribs created page Elliptocytes (Created page with "'''Derivation:''' ''a flattened circle; in morphological usage the word tends to be applied to cells that are significantly elongated (length>twice the diameter)'' ---- '''Appearance''' Elliptocytes have an elliptical or “cigar-shaped” form – the key is that the cell is rounded and not curved (in contrast to the sharp-ended and curved sickle cell. <span style="font-size:90%"><span style="color:#808080"> <gallery widths="180px" heights="180px" > File:ELLIP1.p...")
- 14:30, 16 February 2023 John talk contribs created page Dimorphic (Created page with " '''Derivation:''' ''From Greek di- ‘twice’ + morphē ‘form’'' ---- '''Appearance''' The occurrence of two populations of circulating erythrocytes that have different morphological features. Generally (but not exclusively), a fairly normal population co-exists with an abnormal population (characterised by different colour, size, and/or shape). '<gallery mode="nolines" widths="240px" heights="240px" > File:Dimorphic1.png|link={{filepath:Dimorphic1.png}}...")
- 14:29, 16 February 2023 John talk contribs created page Haemoglobin crystals (Created page with " '''Derivation:''' ''Descriptive term: haemoglobin in crystalline form within an erythrocyte'' ---- '''Appearance''' Variously described as tetragonal, hexagonal or rhomboidal crystals, but in practice highly variable shapes resembling rods, solid lumps or geometric shapes (see pathogenesis). The remainder of the cell will have reduced haemoglobin content and may have an empty (“ghost”) appearance. <span style="font-size:90%"><span style="color:#808080"> <gal...")
- 14:27, 16 February 2023 John talk contribs created page Cabot rings (Created page with "'''Described by''': Richard Cabot (American physician in 1903) ---- '''Appearance''' They are rarely seen; however when present their appearance is of violet coloured thin strands, that form single or double loops. Most often they are seen in polychromatic red cells. <gallery widths="180px" heights="180px" > File:Cabot_ring.jpg|link={{filepath:Cabot_ring.jpg}} </gallery> <span style="font-size:90%"> '''Image:''' Cabot ring in 'figure of 8' appearance, within a...")
- 14:25, 16 February 2023 John talk contribs created page Basophilic stippling (Created page with "(punctate basophilia) '''Derivation:''' ''mixed language: base [cationic] philien [to love] stippen [to prick]'' ---- '''Appearance''' The inclusions are blue, fairly evenly spread through the erythrocyte cytoplasm and generally too frequent to easily count (typically there will be considerably more than 10 dots present). When fine it may be difficult to detect at low power, and may best detected by gently focusing up and down at high power. More coarse stippling ma...")
- 14:23, 16 February 2023 John talk contribs created page Agglutination (Created page with " '''Derivation:''' ''From latin “fasten with glue”'' ---- '''Description''' Erythrocytes linked together to form irregular clumps of varying size. <gallery mode="nolines" widths="240px" heights="240px" border="1px" > File:Aggs.png|link={{filepath:Aggs.png}} File:Aggs.jpg|link={{filepath:Aggs.jpg}} </gallery> <span style="font-style:italic; font-size:90%;'' > '''Appearance:''' The key points are that the red cell groups are very irregular. In many cases...")
- 14:21, 16 February 2023 John talk contribs created page Acanthocytes (Created page with "(spur cells or sputnik cells) '''Derivation:''' ''Greek acantha [thorn] '' ---- '''Appearance''' The cell body is generally dense and contracted, but the major feature is the presence of around 2-20 spicules. These are irregularly distributed across surface of the cell and may be sharp or club shaped. <gallery widths="180px" heights="180px" > File:Ac2.png|link={{filepath:Ac2.png}} </gallery> <span style="font-size:90%"> '''''Image 1''' The cell body may be dense...")
- 10:35, 27 January 2023 John talk contribs created page Test (Created page with " ---- '''Appearance:''' Neutrophils forming aggregates on a blood smear (most frequently seen on the edges) and monocytes may be seen within these aggregates. Less commonly aggregates may be comprised of lymphocytes.. ---- '''Images of agglutination:''' <gallery mode="nolines" widths="300px" heights="300px" > File:Agg.jpg|leftt|link= File:Agg2.jpg|leftt|link= File:Agg3.jpg|leftt|link= </gallery> ''An EDTA-dependent phenomenon seen in neutrophils (image 1) and oc...")
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