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<span style="color:navy>1. ''Markers used mainly for gating:''</span>
{|style="width: 80px; height: 80px; text-align:center; font-style: bold; font-size: 120%; color: teal; background: #cccccc; border-style: solid; border-width: 2px"
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[[CD45|<span style="color:teal">'''CD45'''</span>]]
|}
----
----


''CLICK ON '''GENE NAME''' FOR MORE DETAILS''




{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: navy; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
<span style="color:navy>2. ''Non CD-classified markers''</span>
 
 
{|style="float:left; width: 80px; height: 80px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 2px; margin: 5px"
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'''[[EP300|<span style="color:black">'''EP300'''</span>]]'''
'''[[Immunoglobulin light chains|<span style="color:teal">'''kappa'''</span>]]'''
|}
|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: green; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: navy; border-style: solid; border-width: 15px; margin: 5px"
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'''[[IRF4|<span style="color:black">'''IRF4'''</span>]]'''
'''[[Immunoglobulin light chains|lambda]]'''
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|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: orange; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: navy; border-style: solid; border-width: 15px; margin: 5px"
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'''[[PI3KD|<span style="color:black">'''PI3KD'''</span>]]'''
'''[[FMC7]]'''
|}
|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: navy; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: navy; border-style: solid; border-width: 15px; margin: 5px"
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'''[[TDT]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: italic; color: navy; border-style: solid; border-width: 15px; margin: 5px"
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'''[[MPO]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: navy; border-style: solid; border-width: 15px; margin: 5px"
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'''[[IgM]]'''
|}
----
 
 
 
3. '''CD-classified markers frequently used in leukaemia diagnosis'''
 
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[ARID1A|<span style="color:black">'''ARID1A'''</span>]]'''
'''[[CD2]]'''
|}
|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: orange; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[ARAF|<span style="color:black">'''ARAF'''</span>]]'''
'''[[CD3]]'''
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|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: orange; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[ERBB3|<span style="color:black">'''ERBB3'''</span>]]'''
'''[[CD5]]'''
|}
|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: green; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[KLF2|<span style="color:black">'''KLF2'''</span>]]'''
'''[[CD10]]'''
|}
|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: orange; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[PLCG2|<span style="color:black">'''PLCG2'''</span>]]'''
'''[[CD11c]]'''
|}
|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: orange; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[BIRC3|<span style="color:black">'''BIRC3'''</span>]]'''
'''[[CD13]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD14]]'''
|}
|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: green; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color:teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[ETV6 (lymphoid)|<span style="color:green">'''ETV6'''</span>]]'''
'''[[CD19]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD22]]'''
|}
|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: orange; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[KRAS (lymphoid)|<span style="color:black">'''KRAS'''</span>]]'''
'''[[CD23]]'''
|}
|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: orange; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[RHOA|<span style="color:black">'''RHOA'''</span>]]'''
'''[[CD25]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD33]]'''
|}
|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: orange; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[BRAF|<span style="color:black">'''BRAF'''</span>]]'''
'''[[CD34]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal;; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD38]]'''
|}
|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: navy; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[EZH2 (lymphoid)|<span style="color:black">'''EZH2'''</span>]]'''
'''[[CD79a]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD79b]]'''
|}
|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: orange; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[MAP2K1|<span style="color:black">'''MAP2K1'''</span>]]'''
'''[[CD103]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD117]]'''
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|}
{|style="float:left; width: 100px; height: 70px; text-align:center; font-style: bold; color: green; background: #EEEFF7; border-style: solid; border-width: 5px; margin: 5px"
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[STAT3|<span style="color:black">'''STAT3'''</span>]]'''
'''[[CD138]]'''
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{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD200]]'''
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----
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'''Key'''


''<span style="color:navy">Navy: </span>1. Genes associated predominantly with epigenetic processes''
4. '''Other markers helpful in diagnosis'''  


''<span style="color:green">Green: </span>2. Genes associated predominantly with gene transcription''
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: navy; border-style: solid; border-width: 15px; margin: 5px"
 
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''<span style="color:orange">Orange: </span>3. Genes associated predominantly with cell signalling''
'''[[TCRαβ]]'''
 
|}
''<span style="color:gray">Gray: </span>4. Genes associated predominantly with Tumour suppression functions''
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: navy; border-style: solid; border-width: 15px; margin: 5px"
 
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''<span style="color:blue">Blue: </span>5. Genes associated predominantly with DNA repair functions''
'''[[TCRγδ]]'''
 
|}
''<span style="color:red">Red: </span>6. Genes with multiple functions often protein biosynthesis or cell division</span>''
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: navy; border-style: solid; border-width: 15px; margin: 5px"
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'''[[HLA-DR]]'''
|}


<BR clear=all>


{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD1a]]'''*
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD4]]'''*
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD7]]'''*
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD8]]'''*
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD11b]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD15]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD16]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD20]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD24]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD41]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD43]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD56]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD57]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD61]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD64]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD65]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD123]]'''
|}
{|style="float:left; width: 100px; height: 100px; text-align:center; font-style: bold; color: teal; border-style: solid; border-width: 15px; margin: 5px"
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'''[[CD235]]'''
|}


----
----
''<span style="color:navy">Please note that the information is provided for initial guidance only. While we keep the information as up to date as possible, those taking clinical decisions should also consult other sources.</span>''
[[STAT3|STAT3=STAT3]]
[[Mass–energy equivalence|{{abbr|{{math|''E'' {{=}} ''mc''<sup>2</sup>}}|2=Energy = mass times the speed of light squared}}]]

Revision as of 10:57, 21 February 2023



1. Markers used mainly for gating:


CD45


2. Non CD-classified markers


kappa

lambda

FMC7

TDT

MPO

IgM


3. CD-classified markers frequently used in leukaemia diagnosis

CD2

CD3

CD5

CD10

CD11c

CD13

CD14

CD19

CD22

CD23

CD25

CD33

CD34

CD38

CD79a

CD79b

CD103

CD117

CD138

CD200



4. Other markers helpful in diagnosis

TCRαβ

TCRγδ

HLA-DR


CD1a*

CD4*

CD7*

CD8*

CD11b

CD15

CD16

CD20

CD24

CD41

CD43

CD56

CD57

CD61

CD64

CD65

CD123

CD235

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