TCRαβ

Summary

The αβ TCR is the primary form in health accounting for around 95% of circulating T cells. Alteration of that normal expression pattern may suggest a neoplastic or inflammatory disorder

Background

The αβ chains expressed are expressed as part of the T-cell receptor (TCR) complex - these are the antigen recognising parts of the complex. T cells expressing this receptor are referred to as αβ T cells.

Diagnostic Use

• Significant populations expressing gd chains may indicate autoimmune or inflammaotory disease
• γδ restriction or predominance may suggest a γδ lymphoma
• Absence of αβ or γδ is found in NK lineage disorders

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