CD24

Summary

CD24 can be helpful in the confirmation of ALL diagnosis by contributing to assignment of B-lineage in difficult cases.

Background

CD24 is a gpi-linked protein that is expressed on the surface of dendritic cells and most B lymphocytes, and binds to an unknown ligand on T lymphocytes. CD24 is also detected on myelocytes and neutrophils, but not monocytes.

Diagnostic Use

• CD24 can be helpful in diagnosis of difficult cases of ALL or MPAL as it is generally expressed by the primitive B cells of ALL; although CD24 may be absent from pro-B all and occasionally from other cases.

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