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12:11, 11 March 2024 Admin talk contribs uploaded File:MFITr.jpg
12:11, 11 March 2024 Admin talk contribs created page File:MFITr.jpg
12:11, 11 March 2024 Admin talk contribs uploaded File:MFETr.jpg
12:11, 11 March 2024 Admin talk contribs created page File:MFETr.jpg
11:57, 11 March 2024 Admin talk contribs uploaded File:Ring c.jpg
11:57, 11 March 2024 Admin talk contribs created page File:Ring c.jpg
20:03, 8 March 2024 Admin talk contribs created page MediaWiki:Common.css (Created page with "body.page-Main_Page #content h1 { color: #5a7425; font-size: 12px; font-family: "Courier New"; }: ")
17:11, 8 March 2024 Admin talk contribs created page MediaWiki:Sidebar (Created page with " * Red Cell Menu ** mainpage|mainpage-description ** recentchanges-url|recentchanges ** randompage-url|randompage ** helppage|help-mediawiki * SEARCH * TOOLBOX * LANGUAGES")
15:41, 5 March 2024 John talk contribs uploaded File:PFET5p.jpg
15:41, 5 March 2024 John talk contribs created page File:PFET5p.jpg
13:45, 5 March 2024 John talk contribs uploaded File:PFET4p.jpg
13:45, 5 March 2024 John talk contribs created page File:PFET4p.jpg
13:38, 5 March 2024 John talk contribs created page File:PFET3p.jpg
13:38, 5 March 2024 John talk contribs uploaded File:PFET3p.jpg
13:53, 2 March 2024 John talk contribs uploaded a new version of File:PFET2p.jpg
13:45, 2 March 2024 John talk contribs uploaded File:PFET2p.jpg
13:45, 2 March 2024 John talk contribs created page File:PFET2p.jpg
13:38, 2 March 2024 John talk contribs uploaded File:PFET1p.jpg
13:38, 2 March 2024 John talk contribs created page File:PFET1p.jpg
13:54, 26 February 2024 John talk contribs created page ''Plasmodium falciparum'': Morphology (Created page with " ---- '''Geographical distribution''' ''P.falciparum'' infection occurs in tropical and subtropical areas of central and South America, Africa, and S.E.Asia; this resembles the distribution of ''P.malariae'' and overlaps but is distinct from the distribution of ''P.vivax'' and ''P.ovale''. Detailed geographical information may be accessed here: [https://malariaatlas.org/explorer/#/]. ---- '''The early trophozoite''' File:PFET.jpg|left|220px|link={{filepath:PFE...")
12:27, 26 February 2024 John talk contribs uploaded File:PFETi6.jpg
12:27, 26 February 2024 John talk contribs created page File:PFETi6.jpg
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12:22, 26 February 2024 John talk contribs created page File:PFETi5.jpg
12:21, 26 February 2024 John talk contribs uploaded File:PFETi4.jpg
12:21, 26 February 2024 John talk contribs created page File:PFETi4.jpg
12:13, 26 February 2024 John talk contribs uploaded File:PFETi3.jpg
12:13, 26 February 2024 John talk contribs created page File:PFETi3.jpg
12:12, 26 February 2024 John talk contribs uploaded File:PFETi2.jpg
12:12, 26 February 2024 John talk contribs created page File:PFETi2.jpg
12:12, 26 February 2024 John talk contribs uploaded File:PFETi1.jpg
12:12, 26 February 2024 John talk contribs created page File:PFETi1.jpg
18:35, 22 February 2024 John talk contribs uploaded File:PKSc.jpg
18:35, 22 February 2024 John talk contribs created page File:PKSc.jpg
18:35, 22 February 2024 John talk contribs uploaded File:PKGc.jpg
18:35, 22 February 2024 John talk contribs created page File:PKGc.jpg
18:35, 22 February 2024 John talk contribs uploaded File:PKLTc.jpg
18:35, 22 February 2024 John talk contribs created page File:PKLTc.jpg
18:34, 22 February 2024 John talk contribs uploaded File:PKETc.jpg
18:34, 22 February 2024 John talk contribs created page File:PKETc.jpg
13:43, 22 February 2024 John talk contribs created page ''P.falciparum'' gallery (Created page with "<gallery mode="nolines" widths=150px heights=150px> File:PFETc.jpg|<span style="font-size:80%">''Early trophozoite''</span>|link={{filepath:PFETc.jpg}} File:PFLTc.jpg|<span style="font-size:80%">Late trophozoite</span>|link={{filepath:PFLTc.jpg}} File:PFGc.jpg|<span style="font-size:80%">Gametocyte</span>|link={{filepath:PFGc.jpg}} </gallery>")
23:58, 21 February 2024 John talk contribs uploaded File:PMSc.jpg
23:58, 21 February 2024 John talk contribs created page File:PMSc.jpg
23:55, 21 February 2024 John talk contribs uploaded File:PMGc.jpg
23:55, 21 February 2024 John talk contribs created page File:PMGc.jpg
23:55, 21 February 2024 John talk contribs uploaded File:PMLTc.jpg
23:55, 21 February 2024 John talk contribs created page File:PMLTc.jpg
23:54, 21 February 2024 John talk contribs uploaded File:PMETc.jpg
23:54, 21 February 2024 John talk contribs created page File:PMETc.jpg
23:41, 21 February 2024 John talk contribs uploaded File:POGc.gif
23:41, 21 February 2024 John talk contribs created page File:POGc.gif
23:41, 21 February 2024 John talk contribs uploaded File:POSc.jpg
23:41, 21 February 2024 John talk contribs created page File:POSc.jpg
23:40, 21 February 2024 John talk contribs uploaded File:POLTc.jpg
23:40, 21 February 2024 John talk contribs created page File:POLTc.jpg
23:40, 21 February 2024 John talk contribs uploaded File:POETc.jpg
23:40, 21 February 2024 John talk contribs created page File:POETc.jpg
20:08, 21 February 2024 John talk contribs uploaded File:AltPVETc.jpg
20:08, 21 February 2024 John talk contribs created page File:AltPVETc.jpg
20:03, 21 February 2024 John talk contribs uploaded File:FVETc.jpg
20:03, 21 February 2024 John talk contribs created page File:FVETc.jpg
20:00, 21 February 2024 John talk contribs created page File:PVGc.jpg
20:00, 21 February 2024 John talk contribs uploaded File:PVGc.jpg
19:59, 21 February 2024 John talk contribs uploaded File:PVSc.jpg
19:59, 21 February 2024 John talk contribs created page File:PVSc.jpg
19:59, 21 February 2024 John talk contribs uploaded File:PVLTc.jpg
19:59, 21 February 2024 John talk contribs created page File:PVLTc.jpg
19:58, 21 February 2024 John talk contribs uploaded File:FVET.jpg
19:58, 21 February 2024 John talk contribs created page File:FVET.jpg
19:47, 21 February 2024 John talk contribs uploaded a new version of File:PFETc.jpg
19:42, 21 February 2024 John talk contribs uploaded File:PFGc.jpg
19:42, 21 February 2024 John talk contribs created page File:PFGc.jpg
19:42, 21 February 2024 John talk contribs uploaded File:PFLTc.jpg
19:42, 21 February 2024 John talk contribs created page File:PFLTc.jpg
19:39, 21 February 2024 John talk contribs uploaded File:PFETc.jpg
19:39, 21 February 2024 John talk contribs created page File:PFETc.jpg
12:51, 31 January 2024 John talk contribs created page Marker patterns erythroid or megakaryocyte differentiation (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <span style="font-size:90%>'''Acute erythroid leukaemia (AEL)'''</br>This may be a difficult diagnosis since markers will often not allow cells to be distinguished from a re...")
19:24, 30 January 2024 John talk contribs created page Marker patterns of other AML-related differentiation (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- ''These markers are not considered to define myeloid lineage, and generally have lower lineage specificity than myeloid-lineage associated markers, however they can support c...")
19:53, 13 January 2024 John talk contribs created page Flow cytometry: Myeloid-defining markers (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <span style="font-size:90%;>To assign myeloid lineage in MPAL, only lineage-defining charateristics should be considered.</span> <div style="width: 100%; border: 1px solid black; font-size:1...")
19:50, 13 January 2024 John talk contribs created page Flow cytometry: Myeoid-defining markers (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <span style="font-size:90%;>To assign myeloid lineage in MPAL, only lineage-defining charateristics should be considered.</span> <div style="width: 100%; border: 1px solid black; font-size:1...")
14:11, 12 January 2024 John talk contribs created page Table of frequent aberrant markers in AML (Created page with "It is well recognised that marker expression in acute myeloid leukaemia may frequently include the expression of immunological markers not typically associated with myeloid lineage. Broadly, the abberant expression may include: Markers of primitive phenotype that are more frequently associated with lymphoid disorders, most frequently, CD7 43% BCRABL TdT 7% Markers associated with lymphoid maturation that may also be expressed by the lineage maturation, particularly mon...")
00:13, 12 January 2024 John talk contribs created page Recognition of APL differentiation (Created page with " <div id="AML_AplPic">'''Recognition of acute promyelocytic leukaemia'''</div> 130px <span style="font-size:90%">Typical APL has cells that are hypergranular (A) or may be the microgranular variant (B) generally the cells will have a range of granulation or nuclear appearance. While CD45 expression tends to be weak, in almost all cases the variable morphological features cause a wide range of side-scatter with the abnormal cells often forming a...")
00:10, 12 January 2024 John talk contribs created page Recognition of blast cells with monocytic differentiation (Created page with "---- <div id="AML_MonoPic">'''Recognition of blast cells with monocytic differentiation'''</div> 130px|caption '''A''' monoblastic AML 130px|caption '''B''' monocytic AML <span style="font-size:90%"> *'''Panel A''': Where cells have a monoblastic differentiation (generally large blast cells with primitive chromatin and nucleoli that lack ''monocytic shape'' often with basophilic cytoplasm) the monoblasts tend to express marke...")
15:28, 9 January 2024 John talk contribs created page Flow Cytometry:T-Lymphoid lineage assignment in MPAL (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <div style="width: 95%"> {| class="wikitable" style="border-style: solid; border-width: 5px; color:black" |colspan="1" style = "font-size:90%; color:black; background:#bcd4e6"|'''Mixed Pheno...")
12:47, 9 January 2024 John talk contribs created page Flow Cytometry:B-lymphoid lineage assignment in MPAL (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <div style="width: 95%; border: 1px solid black; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" !colspan="2" <span style="font-size:90%...")
12:42, 9 January 2024 John talk contribs created page Flow Cytometry:Myeloid lineage assignment in MPAL (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <div style="width: 100%; border: 1px solid black; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" !colspan="2" <span style="font-size:90...")
17:48, 5 January 2024 John talk contribs uploaded File:Lymphoblast.png
17:48, 5 January 2024 John talk contribs created page File:Lymphoblast.png
13:20, 5 January 2024 John talk contribs created page Tables of diagnostic patterns associated with aberrancy or alternative diagnosis in AML (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> --------")
13:13, 5 January 2024 John talk contribs created page Tables of diagnostic markers supporting assignment of primitive phenotype in AML (Created page with "Markers used to demonstrate primitive nature in AML Atypical patterns of primitive marker expression in acute myeloid leukaemia")
12:50, 5 January 2024 John talk contribs created page Tables of diagnostic markers supporting lineage assignment in AML (Created page with " Myeloid lineage-defining markers")
13:23, 4 January 2024 John talk contribs created page Flow cytometry:ETP-ALL (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> -------- <div style="width: 95%"> {| class="wikitable" style="border-style: solid; border-width: 5px; color:black" |colspan="1" style = "font-size:90%; color:black; background:#ddeee1"|'''1. The primi...")
12:59, 4 January 2024 John talk contribs created page ETP-ALL (Created page with "ETPs are recent immigrants from the bone marrow (BM) to the thymus, derived from hematopoietic stem cells, which retain a certain level of multilineage pluripotency.7,8 By gene expression profiling, ETP cells share similarities with hematopoietic stem cells and myeloid progenitor cells.5 The definition of ETP-ALL/LBL is based on the immunophenotype of the leukemic cells, which are typically CD1a−, CD8−, CD5− (dim), and positive for 1 or more stem cell or myeloid...")
14:02, 2 January 2024 John talk contribs created page Flow cytometry:BPDCN (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <div style="width: 95%"> {| class="wikitable" style="border-style: solid; border-width: 5px; color:black" |colspan="1" style = "font-size:90%; color:black; background:#ddeee...")
15:11, 31 December 2023 John talk contribs created page Flow cytometry:ALAL-NOS (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- Reserved for cases where a primitive haematopoietic malignancy is established but where confident assignment to any specific category is not possible. This diagnosis is rar...")
15:32, 22 December 2023 John talk contribs created page BPDCN (Created page with "Blastic plasmacytoid dendritic cell neoplasm (BPDCN) expresses CD4, CD56 (bright), CD36, CD38, CD43, CD45, CD71, HLA-DR, as well as plasmacytoid dendritic cell (PDC) associated markers (CD123, CD303, CD304, TCF4, TCL1) (2, 18). CD45 expression may range from dim to moderate. SSC of the tumor cells is usually low. CD7 and CD33 are relatively commonly expressed. TdT is positive in approximately one-third of the cases, and occasional cases may express CD117. Based on the WH...")
15:27, 22 December 2023 John talk contribs created page Flow cytometry:Acute Leukaemia of ambiguous lineage not otherwise sepcified (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ----")
14:33, 22 December 2023 John talk contribs created page Flow Cytometry:T-Lymphoid lineage assignment (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ----")
14:28, 22 December 2023 John talk contribs created page Flow Cytometry:B-lymphoid lineage assignment (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ----")
14:26, 22 December 2023 John talk contribs created page Flow Ctrometry:B-lymphoid lineage assignment (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ----")
14:14, 22 December 2023 John talk contribs created page Flow Cytometry:Myeloid lineage assignment (Created page with "---- <div id="MPAL_Table1">'''Table 1'''</div> '''MYELOID LINEAGE ASSIGNMENT''' <span id="anchor_0">‎</span>. <div style="width: 100%; border: 1px solid black; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" !colspan="2" <span style="font-size:90%; font-color:navy; style="text-align: left; border: 1px solid black; background:pale gray">|'''Requirements to assign myeloid lineage in MPAL'''</br></span> <div class="mw-c...")
11:29, 22 December 2023 John talk contribs created page Flow cytometry:AUL (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <span id="anchor_0">‎</span>. <div style="width: 100%; border: 1px solid black; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpad...")
11:19, 22 December 2023 John talk contribs created page Flow cytometry:MPAL (Created page with "---- '''Important Note''' MPAL is uncommon (2-3% of acute leukaemia). Flow cytometry provides initial evidence of MPAL. However conclusions may subsequently be modified (e.g. by results of immunohistochemistry, cytogenetics, or genetics). It is important that the provisional nature of flow cytometry assignment of MPAL is acknowledged. Note that MPAL includes two components that can be considered separately: (1) '''Mixed Phenotype''' - ineage assignment is possible b...")
14:46, 21 December 2023 John talk contribs created page Myeloid lineage-associated markers (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- '''Table: Marker patterns that allow definite assignment of acute myeloid lineage''' <div style="width: 95%"> {| class="wikitable" style="border-style: solid; border-width:...")
14:42, 21 December 2023 John talk contribs created page Myeloid lineage-defining markers (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- '''Table: Marker patterns that allow definite diagnosis of acute myeloid leukaemia''' <div style="width: 95%"> {| class="wikitable" style="border-style: solid; border-width...")
17:45, 20 December 2023 John talk contribs created page Additional immunophenotypic markers useful in lineage assignment or subtyping of AML (Created page with "<div id="AML_Table2B">'''Table 2B'''</div> <div style="width: 95%"> {| class="mw-collapsible mw-collapsed wikitable" style="border-style: solid; border-width: 5px; color:black" data-expandtext="Click to open Table" data-collapsetext="Click to close table" !colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:pale gray">|Myeloid lineage-associated markers (Specific differentiation)'''</span><span style="font-size:90%;...")
15:04, 20 December 2023 John talk contribs created page Immnophenotypic markers in AML (Created page with "---- <div style="width: 200px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black; font-size:90%; color:navy" | colspan="1"''|Return to previous page'' |} </div> ---- <div style="width: 95%"> {| class="wikitable" style="border-style: solid; border-width: 5px; color:black" ! colspan="2" style = "font-size:100%; color:black"| '''Table:''' M...")
12:24, 15 December 2023 John talk contribs uploaded File:AMLM5B.jpg
12:24, 15 December 2023 John talk contribs created page File:AMLM5B.jpg
12:24, 15 December 2023 John talk contribs created page File:AMLM5A.jpg
12:24, 15 December 2023 John talk contribs uploaded File:AMLM5A.jpg
18:58, 11 December 2023 John talk contribs created page Atypical patterns of primitive marker expression in acute myeloid leukaemia (Created page with "<div style="width: 180px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black;" | colspan="1"''|Click to return to AML diagnosis page'' |} </div> <div style="width: 95%"> {| class="wikitable" style="border-style: solid; border-width: 5px; color:black" ! colspan="2" style = "font-size:100%; color:black"| '''Table:''' Markers primarily used t...")
18:57, 11 December 2023 John talk contribs created page Atypical patterns of primitive marker expression in acute leukaemia (Created page with "<div style="width: 180px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black;" | colspan="1"''|Click to return to AML diagnosis page'' |} </div> <div style="width: 95%"> {| class="wikitable" style="border-style: solid; border-width: 5px; color:black" ! colspan="2" style = "font-size:100%; color:black"| '''Table:''' Markers primarily used t...")
18:56, 11 December 2023 John talk contribs created page Markers used to demonstrate primitive nature in AML (Created page with "<div style="width: 180px"> {| class="wikitable" style="border-left:solid 5px green;border-right:solid 5px green;border-top:solid 5px black;border-bottom:solid 5px black;" | colspan="1"''|Click to return to AML diagnosis'' |} </div> <div style="width: 95%"> {| class="wikitable" style="border-style: solid; border-width: 5px; color:black" ! colspan="2" style = "font-size:100%; color:black"| '''Table:''' Markers primarily used to con...")
17:23, 1 December 2023 John talk contribs created page Table (Created page with "<div style="width: 95%"> {| class="mw-collapsible mw-collapsed wikitable" style="border-style: solid; border-width: 5px; color:black" </br>data-expandtext="Click to open Table" data-collapsetext="Click to close table" ! colspan="2" style = "font-size:100%; color:black"| '''Table:''' Markers primarily used to confirm primitive nature in AML. |- |colspan="2" style = "font-size:90%; color:black; background:#ddeee1"|The expression of some markers is typically associa...")
16:59, 28 November 2023 John talk contribs created page The flow cytometric diagnosis of AML (Created page with "Do the cells have flow cytometric features of primitive cells? *Typically these will be (for more detail see table) *In some cases there may be atypical features (for more detail see table) ---- Can we confirm myeloid nature? *Typical cases can generally be recognised by (see table for details) *Atypical cases can still be identified based on a minimal feature set (see table for details) *In unusual cases an extended marker panel may allow lineage assignment (see Table f...")
16:54, 30 October 2023 John talk contribs created page AUL (Created page with "<span id="anchor_0">‎</span>. <div style="width: 100%; border: 1px solid black; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" !colspan="2" <span style="font-size:90%; font-color:navy; style="text-align: left; border: 1px solid black; background:pale gray">|'''What features must be met to diagnose acute undifferentiated leukaemia'''</br></span> <div class="mw-collapsible mw-collapsed" data-expandtext="Click for expl...")
11:06, 18 October 2023 John talk contribs uploaded File:AML M2.png
11:06, 18 October 2023 John talk contribs created page File:AML M2.png
11:03, 18 October 2023 John talk contribs created page File:AML M1.png
11:03, 18 October 2023 John talk contribs uploaded File:AML M1.png
12:49, 17 October 2023 John talk contribs created page CD71 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD71 has value in the recognition of erythroid differentiation in AML where expression levels can be strong. However, it is not fully specific and may also be a maker of high levels of proliferation. Expression is frequent on other AML subtypes including APL and other lineages including cases of ALL. For this reason the mark...")
12:29, 17 October 2023 John talk contribs created page CD36 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :The main practical use for is in the recognition of megakaryocytic lineage, where expression is expected. However this cell surface receptor has a range of ligands and is expressed on other cells including those of monocyte macrophage lineage so the lineage specificity is not solely for this lineage. </div> :<span style...")
18:14, 5 October 2023 John talk contribs created page Important elements in acute myeloid leukaemia diagnosis (Created page with "1. Flow cytometric typing of acute leukaemia should always be regarded as provisional.''' The initial findings of flow cytometry can direct initial treatment. However, blast cell count and lineage may sometimes be subject to modification as other evidence emerges. Reporting should reflect this.</span> ---- 2. It is important to establish that the cells analused have characteristics of primitive "blast cells" Several methods may be used (ideally together) these inclu...")
11:30, 2 October 2023 John talk contribs created page Image Index of red cell forms (Created page with "{|style="float:left; width: 250px; height: 25px; text-align:center; font-style: normal; color: gray; background: #EEEFF7; border-style: solid; border-width: 1px; margin: 1px" | Go to Image index <span style="color:navy">Go to alphabetical list</span> |} <br /> <br /> ---- '''1. Terms applied to groups of red cells''' <gallery mode="nolines" widths="140px" heights="140px" > File:RC_C_agglutination_...")
09:21, 28 July 2023 John talk contribs created page ALT (Created page with "---- '''Sections''' *<span style="font-size:90%;>Markers of "primitive nature": go to section</span> *<span style="font-size:90%;>Core markers of most cases: go to section</span> *<span style="font-size:90%;>Aberrant markers often seen: go to section</span> *<span style="font-size:90%;>Notes 1: specific subtypes: go to section</span> *<span style="font-size:90%;>Notes 2: ambiguous lineage [[#anchor_5|go to section]...")
18:53, 26 July 2023 John talk contribs created page MPAL (Created page with "‎<span id="anchor_0">‎</span>. <div style="width: 100%; border: 1px solid black; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" !colspan="2" <span style="font-size:90%; font-color:navy; text-align:center; border: 1px solid black; background:pale gray">|'''MARKERS USEFUL TO CONFIRM PRIMITIVE NATURE OF BLAST CELLS'''</br></span> |- |colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |'''Useful mark...")
11:58, 17 July 2023 John talk contribs created page Acute leukaemia types (Created page with "<div style="width: 95%; overflow: auto; border: 1px solid navy; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="5" !colspan="4" style = "font-size:110%; color: navy; text-align:center; background:#DEE0DE;"|'''Marker patterns in typical acute myeloid leukaemia''' |- !colspan="4" style = "font-size:90%; background:#DAE8F2"|'''CD45''' expression |- |colspan="4" style = "font-size:90%; color:black;" |Typically expression of C...")
18:10, 14 July 2023 John talk contribs created page Flow cytometry: Plasma cells (Created page with "---- <gallery mode="nolines" widths="200px" heights="200px" border="1px" > file:PC.jpg|link={{filepath:PC.jpg}} </gallery> ---- <span style="color: navy>'''Background to flow cytometric diagnosis'''</span> Differentiation to plasma cells involves (in mast cases) the loss of typical pan B-cell markers and surface light chains. The expression of CD45 also differs both within and between cases making standard gating strategies difficult to apply. Cells are most often id...")
16:04, 14 July 2023 John talk contribs created page Flow cytometry: Lymphoplasmacytic Lymphoma (Created page with "---- 200px|link=LPL.jpg <span style="color: navy>'''Background to flow cytometric diagnosis'''</span> Cells of LPL share features of mature B-cell differentation and features of early plasma cell differentiation, and have mixed populations with features of each (although proportions vary). This can be a challenging diagnosis by flow cytometry alone, but other modalities can generally make this diagnosis clear. <div style="width: 95%; overflow: a...")
10:55, 14 July 2023 John talk contribs created page Flow cytomtery: Lymphoplasmacytic lymphoma (Created page with "---- 200px|link=LPL.jpg <span style="color: navy>'''Background to flow cytometric diagnosis'''</span> Cells of LPL share features of mature B-cell differentation and features of early plasma cell differentiation, and have mixed populations with features of each (although proportions vary). This can be a challenging diagnosis by flow cytometry alone, but other modalities can generally make this diagnosis clear. <div style="width: 95%; overflow: a...")
17:29, 13 July 2023 John talk contribs created page Marker expression in B-lymphoproliferative disorders (Created page with "test ---- '''Marker patterns of B-Cell Lymphoproliferative disorders''' *Chronic lymphocytic leukaemia *Mantle Cell Lymphoma *Follicular Lymphoma *Marginal Zone Lymphoma *Hairy Cell Leukaemia *Flow cytometry: Diffuse Large B-cell Lymphoma|Diffus...")
16:58, 13 July 2023 John talk contribs uploaded a new version of File:CD45-PopA.jpg
16:55, 13 July 2023 John talk contribs uploaded File:CD45-PopA.jpg
16:55, 13 July 2023 John talk contribs created page File:CD45-PopA.jpg
14:49, 13 July 2023 John talk contribs uploaded File:DLBCL.jpg
14:49, 13 July 2023 John talk contribs created page File:DLBCL.jpg
10:27, 13 July 2023 John talk contribs uploaded File:CD45 populations.jpg
10:27, 13 July 2023 John talk contribs created page File:CD45 populations.jpg
10:23, 13 July 2023 John talk contribs uploaded File:CD45-PopE.jpg
10:23, 13 July 2023 John talk contribs created page File:CD45-PopE.jpg
10:22, 13 July 2023 John talk contribs uploaded File:CD45-PopD.jpg
10:22, 13 July 2023 John talk contribs created page File:CD45-PopD.jpg
10:22, 13 July 2023 John talk contribs uploaded File:CD45-PopC.jpg
10:22, 13 July 2023 John talk contribs created page File:CD45-PopC.jpg
10:21, 13 July 2023 John talk contribs uploaded File:CD45-PopB.jpg
10:21, 13 July 2023 John talk contribs created page File:CD45-PopB.jpg
10:14, 13 July 2023 John talk contribs uploaded File:CD45-PopB.png
10:14, 13 July 2023 John talk contribs created page File:CD45-PopB.png
10:10, 13 July 2023 John talk contribs uploaded File:CD45 populations.png
10:10, 13 July 2023 John talk contribs created page File:CD45 populations.png
21:15, 12 July 2023 John talk contribs uploaded File:LPL.jpg
21:15, 12 July 2023 John talk contribs created page File:LPL.jpg
21:15, 12 July 2023 John talk contribs uploaded File:PC.jpg
21:15, 12 July 2023 John talk contribs created page File:PC.jpg
21:14, 12 July 2023 John talk contribs uploaded File:HCL.jpg
21:14, 12 July 2023 John talk contribs created page File:HCL.jpg
21:12, 12 July 2023 John talk contribs uploaded File:MZL.jpg
21:12, 12 July 2023 John talk contribs created page File:MZL.jpg
21:11, 12 July 2023 John talk contribs uploaded File:FL.jpg
21:11, 12 July 2023 John talk contribs created page File:FL.jpg
21:10, 12 July 2023 John talk contribs uploaded File:MCL.jpg
21:10, 12 July 2023 John talk contribs created page File:MCL.jpg
14:21, 12 July 2023 John talk contribs created page Flow cytometry: Diffuse Large B-cell Lymphoma (Created page with "---- 200px|link=BLBCL.jpg <span style="color: navy>'''Background to flow cytometric diagnosis'''</span> This is an uncommon diagnosis by flow cytometry and the immunophenotype is less frequently reported. This table represents the most frequet penotypic features, but emphasises that there is no absolutely typical pattern that sets this diagnosis apart from other B-LPD. However, DLBCL cells generally circulate and involve bone marrow only at only...")
14:15, 12 July 2023 John talk contribs created page Flow cytometry: Mantle Cell Lymphoma (Created page with "---- 200px|link=MCL.jpg <span style="color: navy>'''Background'''</span> Typical MCL expresses CD5, but can be distinguished from CLL by the absence of CD23 and CD200. However, individual markers may not be expressed in all cases - this can cause diagnostic difficulty particularly with atypical forms of CLL or MZL or occasionally other B-cell lymphoproliferative disorders. Generally it is correct to advise cytogenetic or genetic testing to confi...")
14:53, 11 July 2023 John talk contribs created page CD-classified flow cytometry markers (Created page with "---- ''Click on name to access the link to a detailed description of the nature and reactivity for each listed marker:'' {|style="float:left; width: 80px; height: 40px; text-align:center; font-style: bold; color: maroon; background: #faeed8; border-style: solid; border-width: 2px; margin: 5px" | '''<span style="color:maroon">'''kappa'''</span>''' |} {|style="float:left; width: 80px; height: 40px; text-align:center; font-style: bold; co...")
14:52, 11 July 2023 John talk contribs created page Non CD-classified flow cytometry markers markers (Created page with "---- ''Click on name to access the link to a detailed description of the nature and reactivity for each listed marker:'' {|style="float:left; width: 80px; height: 40px; text-align:center; font-style: bold; color: maroon; background: #faeed8; border-style: solid; border-width: 2px; margin: 5px" | '''<span style="color:maroon">'''kappa'''</span>''' |} {|style="float:left; width: 80px; height: 40px; text-align:center; font-style: bold; co...")
13:55, 10 July 2023 John talk contribs created page Marker Tables: B-lymphoproliferative disorders (Created page with "---- '''This table provides a summary - see these notes:''':</span> *<span style="color:black;font-size:90% ">Click the disorder name (top row of table) for full details</span> *<span style="color:black;font-size:90% ">Click the marker name (left column) for description</span> *<span style="color:black;font-size:90% ">Mobile phone users: for full table scroll table left to right or view landscape</span> ---- <div style="width: 100%; overflow: auto; border: 0px solid na...")
13:28, 10 July 2023 John talk contribs created page Description of individual markers (Created page with "---- <span style="color:navy>Click on name to access the link to a detailed description of the nature and reactivity for each listed marker: </span> {|style="float:left; width: 80px; height: 40px; text-align:center; font-style: bold; color: maroon; background: #faeed8; border-style: solid; border-width: 2px; margin: 5px" | '''<span style="color:maroon">'''kappa'''</span>''' |} {|style="float:left; width: 80px; height: 40px; text-align:...")
11:34, 6 July 2023 John talk contribs created page Alt Alt (Created page with " <div style="width: 100%; overflow: auto; border: 1px solid navy; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" !colspan="7" style = "font-size:100%; color: navy; text-align:center; background:#DEE0DE;"|'''Immunophenotype LPD''' |- !colspan="7" style = "font-size:100%; color: navy; text-align:center; background:white;"|'''Immunophenotype LPD''' |- |colspan="1" style = "font-size:80%; width: 20%; |'''Marker''' |colspa...")
09:48, 6 July 2023 John talk contribs created page Alt (Created page with " <div style="width: 100%; overflow: auto; border: 1px solid navy; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" !colspan="7" style = "font-size:100%; color: navy; text-align:center; background:#DEE0DE;"|'''Immunophenotype LPD''' |- |colspan="1" style = "font-size:80%; width: 20%; |'''Marker''' |colspan="1" style = "font-size:80%; width: 10%; |'''CLL''' |colspan="1" style = "font-size:80%; width: 10%; |'''MCL''' |cols...")
15:15, 30 June 2023 John talk contribs created page File:ManWithAbs.jpg
15:15, 30 June 2023 John talk contribs uploaded File:ManWithAbs.jpg
11:10, 30 June 2023 John talk contribs created page Flow cytometry: Hairy Cell Leukaemia (Created page with "---- 200px|link=HCL.jpg <span style="font-size:90%">''Typical HCL morphology, cells are medium size, with a partly activated chromatin pattern and oval or indented nuclear shape, the cytoplasm is typically blue/grey with irregular and fine projections (hairs)''</span> <span style="color: navy>'''Background to flow cytometric diagnosis'''</span> HCL expresses typical and unusual markers that together with morphology can allow diagnosed with some co...")
13:22, 28 June 2023 John talk contribs uploaded File:CLLCD45.jpg
13:22, 28 June 2023 John talk contribs created page File:CLLCD45.jpg
10:19, 28 June 2023 John talk contribs uploaded File:CLL.jpg
10:19, 28 June 2023 John talk contribs created page File:CLL.jpg
23:52, 21 June 2023 John talk contribs created page Flow cytometry: Marginal Zone Lymphoma (Created page with " <span style="color: navy>'''Background'''</span> A difficult diagnosis - flow cytometry can suggest a diagnosis, but the immunophenotype may overlap with related diagnoses including atypical cases of CLL and MCL. Generally it is correct to suggest the diagnosis, but recognise that the profile is not fully specific, and confirmation by other modalities may be required. <div style="width: 95%; overflow: auto; border: 1px solid navy; font-size:100%"> {| class="wikita...")
16:25, 21 June 2023 John talk contribs created page Summary tables comparing neoplastic disorders (Created page with " <div style="width: 100%; overflow: auto; border: 1px solid navy; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" !colspan="4" style = "font-size:100%; color: navy; text-align:center; background:#DEE0DE;"|'''Immunophenotype LPD''' |- |colspan="1" style = "font-size:80%; width: 60%; |'''Marker''' |colspan="1" style = "font-size:80%; width: 20%; |'''CLL''' |colspan="1" style = "font-size:80%; width: 20%; |'''MCL''' |- |c...")
16:18, 21 June 2023 John talk contribs created page Flow cytometry: Chronic Lymphocytic leukaemia (Created page with "<span style="color: navy>'''Background'''</span> Typical CLL can be diagnosed with some confidence using flow cytometry. However, individual markers may not be expressed in all cases - this can cause diagnostic difficulty particularly in distinguishing CLL from atypical cases of MCL or MZL. If this is the case then the atypical features should be reported, and the possibility of alternative diagnoses acknowledged. Note also that cases with a low lymphocytosis (<1x10<...")
16:16, 21 June 2023 John talk contribs created page Flow cytometry: Mantle cell Lymphoma (Created page with " <span style="color: navy>'''Background'''</span> Typical MCL expresses CD5, but can be distinguished from CLL by the absence of CD23 and CD200. However, individual markers may not be expressed in all cases - this can cause diagnostic difficulty particularly with atypical forms of MZL or occasionally other B-cell lymphoproliferative disorders. Generally it is correct to advise cytogenetic or genetic testing to confirm. <div style="width: 95%; overflow: auto; borde...")
16:14, 21 June 2023 John talk contribs created page Flow cytometry: Follicular Lymphoma (Created page with " <span style="color: navy>'''Background'''</span> Typical MCL expresses CD5, but can be distinguished from CLL by the absence of CD23 and CD200. However, individual markers may not be expressed in all cases - this can cause diagnostic difficulty particularly with atypical forms of MZL or occasionally other B-cell lymphoproliferative disorders. Generally it is correct to advise cytogenetic or genetic testing to confirm. <div style="width: 95%; overflow: auto; borde...")
23:34, 20 June 2023 John talk contribs created page NEW (Created page with "<span style="color: navy>'''Background'''</span> Typical CLL can be diagnosed with some confidence using flow cytometry. However, individual markers may not be expressed in all cases - this can cause diagnostic difficulty particularly in distinguishing CLL from atypical cases of MCL or MZL. If this is the case then the atypical features should be reported, and the possibility of alternative diagnoses acknowledged. Note also that cases with a low lymphocytosis (<1x10<...")
22:59, 19 June 2023 John talk contribs created page Flow cytometric marker pattern of mantle cell lymphoma (Created page with " <span style="color: navy>'''Background'''</span> Typical MCL expresses CD5, but can be distinguished from CLL by the absence of CD23 and CD200. However, individual markers may not be expressed in all cases - this can cause diagnostic difficulty particularly with atypical forms of MZL or occasionally other B-cell lymphoproliferative disorders. Where doubt exists then cytogenetic or genetic testing can be helpful. <div style="width: 95%; overflow: auto; border: 1px...")
22:08, 19 June 2023 John talk contribs created page Flow cytometric marker pattern of chronic lymphocytic leukaemia (Created page with " <span style="color: navy>'''Background'''</span> Typical CLL can be diagnosed with some confidence using flow cytometry. However, individual markers may not be expressed in all cases - this can cause diagnostic difficulty particularly in distinguishing CLL from atypical cases of MCL or MZL. If this is the case then the atypical features should be reported, and the possibility of alternative diagnoses acknowledged. Note also that cases with a low lymphocytosis (<1x1...")
10:26, 19 June 2023 John talk contribs created page Test open (Created page with "'Flow cytometry' file mosquito.jpg 200px link malaria index * malaria species recognition species recognition * malaria species recognition stage recognition")
22:54, 18 June 2023 John talk contribs created page Description of marker expression of specific disorders (Created page with "test")
22:49, 18 June 2023 John talk contribs created page Detailed description of individual markers used in diagnosis (Created page with " {|style="float:left; width: 80px; height: 40px; text-align:center; font-style: bold; color: maroon; background: #faeed8; border-style: solid; border-width: 2px; margin: 5px" | '''<span style="color:maroon">'''kappa'''</span>''' |} {|style="float:left; width: 80px; height: 40px; text-align:center; font-style: bold; color: maroon; background: #faeed8; border-style: solid; border-width: 2px; margin: 5px" | '''Immunoglobulin light chains|<...")
16:15, 18 June 2023 John talk contribs created page Expression strength key (Created page with "Expression strength effectively reflects how strongly a molecule is expressed by neoplastic cells based on the intensity of the observed fluorescence. It can be helpful in flow cytometric diagnosis: e.g. the characteristically weak expression of CD79b by CLL cells, or the characteristically strong expression of CD25 by the cells of HCL It is however associated with some difficulties since antibodies and fluorochromes can differ between laboratories and the judgment i...")
15:55, 18 June 2023 John talk contribs created page Monoclonal B lymphocytosis (Created page with "Monoclonal B-lymphocytosis (MBL) as a distinct entity recognised in the WHO Classification and used to denote the presence of abnormal conal B-cells that do not meet the diagnostic criteria for CLL or other LPD based. It is an important distinction since affected individaual are not regarded as having a lymphoproliferative disorder, although they may experience some symptoms, and the disease may progress. The diagnosis is suggested from flow cytometry of blood, but alwa...")
12:07, 14 June 2023 John talk contribs created page CD235 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
12:07, 14 June 2023 John talk contribs created page CD123 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
12:06, 14 June 2023 John talk contribs created page CD65 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
12:06, 14 June 2023 John talk contribs created page CD64 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
20:54, 13 June 2023 John talk contribs created page CD138 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD138 is a marker used to identify normal or malignant plasma cells with a high level of specificity, but does not discriminate normal from abnormal plasma cells and in some cases expression in myeloma may be low compared with normal plasma cells so sensitivity can be an issue. Abberancy of expression is low, but expression...")
16:01, 13 June 2023 John talk contribs created page CD200 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD200 is not lineage specific being seen in a lymphoid and myeloid disorders but has an role in diagnosis: CD200 expression aids the distinction between CLL where expression is consistent and mantle cell lymphoma (MCL) where expression is rare. It is important to realise that CD200 is not a CLL-specific marker and is also ex...")
12:42, 12 June 2023 John talk contribs created page CD117 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD117 is a widely expressed molecule that in haematology is used most often as a marker of primitive myeloid cells where it contributes to a diagnosis of AML. However expression is absent in around 20-30% of typical AML and there is recognised aberrant expression by up to 30% of ALL cases (more frequently in T lineage). CD11...")
11:21, 12 June 2023 John talk contribs created page CD103 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :The principle use of CD103 is to identify hairy cell leukaemia (HCL) and distinguish it from related diorders. CD103 also has a wider range of applications in the histopathological identification of a range of myeloid and T-cell disorders. </div> <span style="color:navy">'''Normal expression and function'''</span> CD1...")
16:15, 11 June 2023 John talk contribs created page CD57 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD57 is used in the identification and typing of LGL cells helping to differentiate between T- and LGL origin </div> :<span style="color:navy">'''Background'''</span> CD57 is a carbohydrate epitope expressed on the cell surface of T cells and peripheral NK cells where CD57 expression can be regarded as designating termi...")
13:20, 8 June 2023 John talk contribs created page CD56 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD56 principally is used in the identification and classification of LGL disorders; CD56 is also expressed in some cases of myeloma and may be used in detection of MRD. </div> :<span style="color:navy">'''Background'''</span> CD56 (Neural Cell Adhesion Molecule or NCAM) as most expressed on natural killer cells, but has...")
18:31, 7 June 2023 John talk contribs created page CD24 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD24 can be helpful in the confirmation of ALL diagnosis by contributing to assignment of B-lineage in difficult cases. </div> :<span style="color:navy">'''Background'''</span> CD24 is a gpi-linked protein that is expressed on the surface of dendritic cells and most B lymphocytes, and binds to an unknown ligand on T lym...")
10:41, 7 June 2023 John talk contribs created page CD79b (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD79b is a pan-B-cell marker expressed from early commitment to B-cell lineage then becoming lost during plasma cell differentiation; CD79b may be used as marker of B-cel lineage, but its more variable expression make it less useful than CD79a or CD19 in this context :The major diagnostic value of CD79b is its characteristi...")
12:57, 1 June 2023 John talk contribs created page IgM (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :mu is the heavy chain element of IgM, and may be detected in the cytoplasm of early B cells. Membrane mu is present on mature B cells but following antigen encounter mu is generally replaced by other heavy chain types. Mu expression is used in the immunophenotypic sub-classification of ALL since cytoplasmic mu is acquired by...")
16:56, 31 May 2023 John talk contribs created page CD20 (Created page with "<div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD20 is a component of the B-cell receptor and is therefore expressed by mature B-lymphocytes. In many ways its expression is similar to that of CD19; however CD20 expression is acquired slightly later in B cell development and may be retained by somr plasma cells. </div> :<span style="color:navy">'''Background'''</span>...")
09:57, 31 May 2023 John talk contribs created page CD16 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
09:42, 31 May 2023 John talk contribs created page MPO (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span> <span style="font-...")
09:57, 30 May 2023 John talk contribs created page CD15 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :The main practical use for CD15 is for the recognition of cells that have granulocytic or monocytic features. For this reason CD15 has a role in lineage distinction in AML. CD15 is however also expressed in a range of haematological cell types and was originally described as the Lewis blood group antigen: Sialyl Lewis X....")
16:38, 28 May 2023 John talk contribs created page FMC7 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :The FMC7 antibody recognises an epitope of CD20 that has a more restricted pattern of expression than the parent molecule. FMC7 has high expression on late-stage b-cell neoplasms such as hairy-cell leukaemia or MZL and can be used to indicate their possible presence; however low level of FMC7 expression is frequent on other...")
18:14, 27 May 2023 John talk contribs created page Immunoglobulin light chains (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span> <span style="font-...")
17:31, 27 May 2023 John talk contribs created page CD11b (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :Expressed on acute myeloid leukaemias with more mature features, particularly those with granulocytic maturation, CD11b is also expressed on monocytes (although less so than CD11c). Expression of CD11b may be used to support the identification of mixed phenotype acute leukaemia MPAL. </div> :<span style="color:navy">'''B...")
16:01, 18 May 2023 John talk contribs created page TDT (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span> <span style="font-...")
12:43, 17 May 2023 John talk contribs created page CD34 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :Often regarded as a marker of primitive phenotype, CD34 is expressed by many cases of ALL (around 50%) and slightly fewer cases of AML around (40%). CD34 is also expressed by regenerating cells in marrow, and particularly by regenerating B lymphocytes (haematogones), but is generally absent from mature haematopoietic cells....")
18:35, 16 May 2023 John talk contribs created page HLA-DR (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
10:24, 16 May 2023 John talk contribs created page CD33 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD33 a useful marker contributing to the diagnosis of AML, but is less specific than myeloperoxidase and may be less sensitive than CD117. :The molecule is expressed by normal maturing myeloid cells, and there is recognised aberrant expression by primitive lymphoid cells (10-20%). </div> <span style="color:navy">'...")
14:34, 15 May 2023 John talk contribs created page CD25 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :Principally a marker of cell activation that is expressed by a range of haematopoietic lineages, The expression of CD25 has value in the diagnosis of several disorders although in each case expression is not fully specific and the level of expression may be key to diagnosis :*High levels of CD25 are typical in hairy cell le...")
21:24, 14 May 2023 John talk contribs created page TCRγδ (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :The αβ TCR is the primary form in health accounting for around 95% of circulating T cells. Alteration of that normal expression pattern may suggest a neoplastic or inflammatory disorder </div> :<span style="color:navy">'''Background'''</span> :The αβ chains expressed are expressed as part of the T-cell receptor (TCR...")
11:48, 14 May 2023 John talk contribs created page TCRαβ (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :In the detection of haematological malignancy the purpose of detecting γδ T cells is to define particular T cell lymphomas (αβ T cells strongly predominate in normal blood). However care must be taken when small populations of γδ T cells are detected however, since these may arise in response to viral or other immune r...")
10:48, 13 May 2023 John talk contribs created page CD7 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
21:05, 12 May 2023 John talk contribs created page CD23 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span> <span style="font-...")
20:32, 11 May 2023 John talk contribs created page CD4 & CD8 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :'''Systemic disease:''' On T lymphocytes these two co-stimulatory molecules define different functional types; an altered ratio between CD4 and CD8 cells can indicate systemic disease or immune dysfunction :'''Neoplasia:''' Expanded populations of CD4 or CD8 cells (or T cells with unusual expression patterns of these molecules) may represent a malignant clone, and the CD4...")
15:53, 10 May 2023 John talk contribs created page CD61 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
15:53, 10 May 2023 John talk contribs created page CD43 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
15:52, 10 May 2023 John talk contribs created page CD41 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
12:43, 9 May 2023 John talk contribs created page CD22 (Created page with "CD22 expression is largely restricted to b cell lineage and expression is acquired at an early differentiation stage. *expression varies during mature b-cell development however the major value of CD22 lies in the identification of all based on high lineage-specificity and very early acquisition allowing the identification of pro-b all. normal expression and function CD22 is a membrane receptor that binds sialic acid containing glycans and expression is mostly rest...")
23:16, 8 May 2023 John talk contribs created page CD1a (Created page with "A T cell marker that has value in specific circumstances Background CD1a is structurally related to major histocompatibility complex proteins and is thought to mediate the presentation of lipid and glycolipid antigens. CD1a expression is absent on very early thymocytes, but is acquired together with CD4 and CD8 as T cells develop in the thymus, then is lost in mature T cells. Diagnostic Use :A marker of early T-lineage :CD1A us useful in the identification of some cas...")
21:58, 8 May 2023 John talk contribs created page CD19 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span> <span style="font-...")
13:23, 7 May 2023 John talk contribs created page CD10 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD10 is expressed early pre-B ALL ("common ALL"), but also has wide expression on all subtypes notably also being expressed by Burkitt lymphoma and many cases of T-ALL :CD10 is also found on normal developing B-lymphocytes (haematogones) so is found very frequently in regenerating marrows :In mature lymphoproliferative...")
14:13, 6 May 2023 John talk contribs created page CD2 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD2 is a pan t-cell marker. In diagnostic use it may be less reliable than CD3 for identification of T-cell lineage, since loss of CD2 expression is seen in some peripheral T-cell lymphomas, and aberrant expression in AML is recognised (particularly the APL subtype). </div> <span style="color:navy">'''Normal expressi...")
12:44, 6 May 2023 John talk contribs created page Extra (Created page with "CD14 aids recognition of bacteria by cells of monocytic lineage. it may generally be regarded as a pan-monocyte antigen when expressed in aml CD14 is a marker of monocytic lineage absence of CD14 expression does not preclude monocytic lineage since some typical monoblasts do not express this marker CD14 is not restricted to malignant cells and will be expressed by reactive monocytes and also by neoplastic cells of cmml normal expression and function together...")
11:59, 6 May 2023 John talk contribs created page CD14 (Created page with "(259, 'cd14', ' cd14 aids recognition ofu800 bacteria byu800 cells ofu800 monocytic lineage. itu800 mayu800 generally beu800 regarded asu800 au800 panu800-monocyte antigen * when expressed inu800 amlu800 cd14 isu800 au800 marker ofu800 monocytic lineage * absence ofu800 cd14 expression does notu800 preclude monocytic lineage since some typical monoblasts dou800 notu800 express this marker * cd14 isu800 notu800 restricted tou800 malignant cells andu800 will beu800 express...")
22:57, 3 May 2023 John talk contribs created page CD79a (Created page with "<span style="color:navy">'''''DETAILS'''''</span> CD38 helps mobilise intracellular calcium to activate a wide array of cell functions. In haematological cell types CD38 it is widely expressed by lymphoid cells )B, T and NK) as well as myeloid precursor cells and mature myeloid cells. It has particular diagnostic importance for lymphocytes where CD38 expression is acquired as stem cells commit to B-cell lineage, then is lost as mature B cells emerge from bone marrow be...")
14:10, 3 May 2023 John talk contribs created page Key to marker expression table (Created page with " <span style="font-size:80%">'''''1. Colour key:''''' ''- the likelihood of any individual case expressing this marker, indicated by colour:'' </span> {| class=wikitable style="text-align: left; font-size:80%; width: 60%; height: 30px; |style= "width: 16.6%; background: #FFE4E1; |Few reported studies (though likely rare) |} {| class=wikitable style="text-align: left; font-size:80%; width:60%; height: 30px; |style= "width: 16.6%; background: #E6FAFF; |Expression may b...")
15:28, 1 May 2023 John talk contribs created page CD4 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :'''Systemic disease:''' On T lymphocytes these two co-stimulatory molecules define different functional types; an altered ratio between CD4 and CD8 cells can indicate systemic disease or immune dysfunction :'''Neoplasia:''' Expanded populations of CD4 or CD8 cells (or T cells with unusual expression patterns of these molecules) may represent a malignant clone, and the CD4...")
10:21, 1 May 2023 John talk contribs created page CD11c (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span>")
20:51, 30 April 2023 John talk contribs created page CD3 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span>")
17:10, 30 April 2023 John talk contribs created page CD5 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :'''For mature B cell neoplasms''': CD5 is used to indicate likely CLL or MCL. However, expression is present on a subset of normal B cells, and also less frequently on other lymphoma types. Full interpretation therefore requires consideration of clonality and other markers. :'''In acute lymphoblastic leukaemia''': CD5 is u...")
10:24, 30 April 2023 John talk contribs created page CD45 (Created page with "<span style="color:navy">'''''SUMMARY TABLES'''''</span> {| class=wikitable style="text-align: center; font-size:80%; width: 100%; height 20px;" |- !colspan="7"|<span style="font-size:100%">'''CD13 expression: primitive cell types'''</font> |- ! AML !! B ALL !! Burkitt || T ALL !! ETP ALL ('''i''') !! MPAL '''i || Hgns '''i''' |- |style="width: 14.25%; background: #FFE4E1 #FFE4E1 #66e0ff #00b8e6 #006699; color:white"|Limited Rare Possible...")
13:46, 26 April 2023 John talk contribs created page CD38 (Created page with " <span style="color:navy">'''''DETAILS'''''</span> CD38 helps initiate the mobilsation of intracellular calcium, activating a wide array of cell functions that depend on cell type. In haematological cell types CD38 is widely expressed by lymphoid cells and by particular myeloid cells – often in a stage-specific manner. For B lymphocytes CD38 expression is acquired as stem cells commit to B-cell lineage, then lost as mature B cells emerge from bone marrow before be...")
12:50, 26 April 2023 John talk contribs created page CD13 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> *The principle diagnostic value of CD38 is that its expression is retained and generally increased during differentiation to plasma cells *CD38 expression has some value in predicting prognosis in CLL *CD38 is also expressed by committed stem cells together with CD34 and can occasionally be of value in acute leukaemia diagnosis </div> <span style="color:navy">'''Norma...")
12:36, 26 April 2023 John talk contribs created page Flow Cytometry (Created page with " <span style="color:navy>1. ''Markers used mainly for gating:''</span> {|style="width: 80px; height: 80px; text-align:center; font-style: bold; font-size: 120%; color: teal; background: #ededed; border-style: solid; border-width: 2px" | <span style="color:teal">'''CD45'''</span> |} ---- <span style="color:navy>2. ''Non CD-classified markers''</span> {|style="float:left; width: 80px; height: 80px; text-align:center; font-style: bold; color: maroon; back...")
16:50, 23 April 2023 John talk contribs created page Ex-flagellation (Created page with "<span style="color:navy>'''Description'''</span> The male and female gametocytes of the malarial parasite may continue to mature in stored blood, in particular the pH change and temperature change may resemble changes normally encountered in the mosquito stomach, where the male gametocyte releases the microgametes as part of sexual replication. This process can be detected in some stored cases. ---- Early trophozoites: <gallery mode="nolines" widths="220px" heights...")
16:27, 23 April 2023 John talk contribs created page Ring forms (Created page with " ---- '''What is a ring form''' <gallery mode="nolines" widths="220px" heights="220px" > File:Ring_cartoon.jpg|link={{filepath:|MFETr.jpg}} </gallery> The earliest stage following red cell invasion has a typical ting form: *a = chromatin dot *b = digestive vacuole *c = parasite cytoplasm ---- <span style="color:navy>'''Description'''</span> At the earliest stage of red cell infection parasites have a ring form and distinction between species may not be easy (or ev...")
16:10, 23 April 2023 John talk contribs created page Distrorted erythrocyte shape (Created page with " ---- <gallery mode="nolines" widths="220px" heights="220px" > File:MDi1.jpg|: ''P.vivax''|link={{filepath:MDi1.jpg}} </gallery> <span style="color:navy>'''Description'''</span> Distortion of the erythrocyte shape is one of the modifications caused by parasite invasion. The most substantial distortion is caused by ''P.vivax'' in which the red cells become both enlarged and irregular in shape. <span style="color:navy>'''Species significance'''</span> Marked red...")
16:08, 23 April 2023 John talk contribs created page Phagocytosed malaria pigment (Created page with " ---- '''Appearance:''' In the context of malarial infection the neutrophils may contain masses of phagocytosed brown or golden malaria pigment within their cytoplasm. ---- '''Images of malaria pigment''' <gallery mode="nolines" widths="270px" heights="300px" > File:Mp1.jpg|link= File:Mp2.jpg|link= File:Mp3.jpg|link= </gallery> <span style="font-size:85%"> ''Images of neutrophils containing malaria pigment: Image 1 shows a schizont in the process of releasing daug...")
16:06, 23 April 2023 John talk contribs created page Malaria pigment (Created page with " ---- <gallery mode="nolines" widths="220px" heights="220px" > File:MPi1.jpg|: ''P.malariae'' with golden pigment over the parasite surface|link={{filepath:MPi1.jpg}} </gallery> <span style="color:navy>'''Description'''</span> During their development malarial parasites metabolise the haemoglobin within erythrocytes to support their growth - hence infected cells become "ghost cells" devoid of visible haemoglobin at later stages of parasite development. As part of th...")
16:01, 23 April 2023 John talk contribs created page Schüffner's dots (Created page with " ---- <gallery mode="nolines" widths="220px" heights="220px" > File:MSc1.jpg|link={{filepath:MSc1.jpg}} File:MSc2.jpg|link={{filepath:MSc2.jpg}} File:MSc3.jpg|link={{filepath:MSc3.jpg}} File:MSc4.jpg|link={{filepath:MSc4.jpg}} </gallery> Different intensities of cytoplasmic dots, from faint to intense during the development of ''P.vivax''. Note that even when faint the number of dots is high (compare with the Maurer's dots and clefts of ''P.falciparum'') <span style...")
15:58, 23 April 2023 John talk contribs created page Band appearance (Created page with " ---- <gallery mode="nolines" widths="220px" heights="220px" > File:MBa3.jpg|: ''P.malarae'' mature band|link={{filepath:MBa3.jpg}} File:Mba3.jpg|: ''P.malarae'' early band|link={{filepath:MBa3.jpg}} File:MBa2.jpg|: ''P.malarae'' mature band|link={{filepath:MBa2.jpg}} </gallery> <span style="color:navy>'''Description'''</span> An early or late trophozoite form that is very elongated and extends close to, or entirely across, the diameter of the erythocyte <span s...")
14:30, 23 April 2023 John talk contribs created page Banana gametocyte (Created page with " ---- <gallery mode="nolines" widths="220px" heights="220px" > File:MB1.jpg|: ''P.falciparum'' macrogametocyte|link={{filepath:MB1.jpg}} File:MB2.jpg|: ''P.falciparum microgametocyte''|link={{filepath:MB2.jpg}} </gallery> <span style="color:navy>'''Description'''</span> The gametocyte stage of ''P.falciparum'' has the form of a round-ended rod. The rod is slightly longer than a red cell so becomes curved by the red cell membrane and is often described a "banana shap...")
14:29, 23 April 2023 John talk contribs created page Amoeboid forms (Created page with " ---- <gallery mode="nolines" widths="220px" heights="220px" > File:MAm2.jpg|: ''P.vivax''|link={{filepath:MAm2.jpg}} </gallery> <span style="color:navy>'''Description'''</span> The late trophozoite of ''P.vivax'' becomes more solid, but with an irregular form that is said to resemble an amoeba with extended processes. Other features of the species will also be detected. <span style="color:navy>'''Species significance'''</span> A fairly specific feature of ''P...")

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