CD61

Summary

A marker of megakaryocytic lineage that is also expressed at lower levels by cells of monocyte macrophage lineage.

Background

CD61 is the beta integrin beta III chain of the platelet IIbIIIa adhesion receptor. CD61 may therefore be regarded as a marker of megakaryocytic lineage. however when combined with an alternative alpha chain alpha v CD61 forms part of the vitronectin receptor. The vitronectin receptor is expressed on a range of cell types including cells of monocyte macrophage lineage.

Diagnostic Use

• Both CD41 and CD61 are valuable to confirm megakaryocytic differentiation in acute myeloid leukaemia

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