CD41

Summary

A reliable and specific marker that can be used to identify megakaryocyte lineage characteristics.

Background

CD41 and CD61 respectively represent the alpha or beta chains that together form the IIbIIIa receptor that mediates the binding of activated platelets to fibrinogen during platelet aggregation.

Diagnostic Use

• The alpha IIb only forms part of this receptor and therefore has very good specificity for identifying megakaryocytic differentiation

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