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Marker patterns of other AML-related differentiation

From haematologyetc.co.uk

Revision as of 19:25, 30 January 2024 by John (talk | contribs)


Markers associated with erythroid differentiation in AML
Most often AML with erythroid maturation will express CD34, while CD45 and HLA-DR are weak or negative. CD117 is generally expressed. There may be some expression of megkaryocytic markers in some cases.
CD36 Expression is expected, but often expressed in other subtypes so not fully lineage specific
CD71 Frequently expressed though not fully lineage specific
CD235 A good marker of erythroid differentiation but acquired late and therefore may not be expressed

Markers associated with megakaryocytic differentiation in AML
Most often CD34, CD45 and HLA-DR are weak or negative, although CD13 and CD33 may be expressed
CD41 Platelet glycoprotein IIbIIIa
CD61 Platelet glycoprotein IIIa
CD36 Relatively non-specific (seen in erythroid and monocytic leukaemias) but often strongly expressed

Markers associated with basophilic differentiation in AML
comment
CD22
CD123
CD203
CD11b