Marker patterns of other AML-related differentiation: Difference between revisions
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Acute erythroid leukaemia (AEL) may be a difficult diagnosis since markers will often not allow cells to be distinguished from a reactive erythroid expansion, and the overlap with cases of myelodysplasia-related AML may have a marked erythroid expansion. | Acute erythroid leukaemia (AEL) may be a difficult diagnosis since markers will often not allow cells to be distinguished from a reactive erythroid expansion, and the overlap with cases of myelodysplasia-related AML may have a marked erythroid expansion. In such cases the diagnosis of AEL requires careful exclusion of other disorders by correlation with morphology and other tests. | ||
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!colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:lightgrey">|'''Markers associated with erythroid differentiation in AML'''</span><span style="font-size:90%; text-align:left; background:white"> | !colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:lightgrey">|'''Markers associated with erythroid differentiation in AML'''</span><span style="font-size:90%; text-align:left; background:white"> | ||
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|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" | | |colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |In AEL cases may vary but may have very weak expression of [[CD45]] and [[HLA-DR}}. In contrast [[CD34]] and often [[CD117]] will be detected.</br>Markers of erythroid differentiation are helpful but require careful interpretation. | ||
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD36]]''' | |colspan="1" style = "font-size:90%; color:black;" |'''[[CD36]]''' | ||
|colspan="1" style = "font-size:84%;"|Expression is expected, but | |colspan="1" style = "font-size:84%;"|Expression is expected, but is not fully lineage specific as it may be seen in other AML forms including cases with monocytic differentiation. | ||
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD71]]''' | |colspan="1" style = "font-size:90%; color:black;" |'''[[CD71]]''' | ||
Revision as of 19:40, 30 January 2024
Acute erythroid leukaemia (AEL) may be a difficult diagnosis since markers will often not allow cells to be distinguished from a reactive erythroid expansion, and the overlap with cases of myelodysplasia-related AML may have a marked erythroid expansion. In such cases the diagnosis of AEL requires careful exclusion of other disorders by correlation with morphology and other tests.
| Markers associated with erythroid differentiation in AML | |
|---|---|
| In AEL cases may vary but may have very weak expression of CD45 and [[HLA-DR}}. In contrast CD34 and often CD117 will be detected. Markers of erythroid differentiation are helpful but require careful interpretation. | |
| CD36 | Expression is expected, but is not fully lineage specific as it may be seen in other AML forms including cases with monocytic differentiation. |
| CD71 | Frequently expressed though not fully lineage specific |
| CD235 | A good marker of erythroid differentiation but acquired late and therefore may not be expressed
|
| Markers associated with megakaryocytic differentiation in AML | |
|---|---|
| Most often CD34, CD45 and HLA-DR are weak or negative, although CD13 and CD33 may be expressed | |
| CD41 | Platelet glycoprotein IIbIIIa |
| CD61 | Platelet glycoprotein IIIa |
| CD36 | Relatively non-specific (seen in erythroid and monocytic leukaemias) but often strongly expressed
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