Marker patterns of other AML-related differentiation: Difference between revisions
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Acute erythroid leukaemia (AEL) may be a difficult diagnosis since markers will often not allow cells to be distinguished from a reactive erythroid expansion, and the overlap with cases of myelodysplasia-related AML may have a marked erythroid expansion. | |||
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!colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:lightgrey">|'''Markers associated with erythroid differentiation in AML'''</span><span style="font-size:90%; text-align:left; background:white"> | !colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:lightgrey">|'''Markers associated with erythroid differentiation in AML'''</span><span style="font-size:90%; text-align:left; background:white"> | ||
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|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |Most often AML with erythroid maturation will express [[CD34]], while [[CD45]] and [[HLA-DR]] | |colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |Most often AML with erythroid maturation will express [[CD34]], while [[CD45]] and [[HLA-DR]] is variable but may be weak or negative. [[CD117]] is generally expressed. There may be some expression of megkaryocytic markers in some cases. | ||
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD36]]''' | |colspan="1" style = "font-size:90%; color:black;" |'''[[CD36]]''' | ||
Revision as of 19:32, 30 January 2024
Acute erythroid leukaemia (AEL) may be a difficult diagnosis since markers will often not allow cells to be distinguished from a reactive erythroid expansion, and the overlap with cases of myelodysplasia-related AML may have a marked erythroid expansion.
| Markers associated with erythroid differentiation in AML | |
|---|---|
| Most often AML with erythroid maturation will express CD34, while CD45 and HLA-DR is variable but may be weak or negative. CD117 is generally expressed. There may be some expression of megkaryocytic markers in some cases. | |
| CD36 | Expression is expected, but often expressed in other subtypes so not fully lineage specific |
| CD71 | Frequently expressed though not fully lineage specific |
| CD235 | A good marker of erythroid differentiation but acquired late and therefore may not be expressed
|
| Markers associated with megakaryocytic differentiation in AML | |
|---|---|
| Most often CD34, CD45 and HLA-DR are weak or negative, although CD13 and CD33 may be expressed | |
| CD41 | Platelet glycoprotein IIbIIIa |
| CD61 | Platelet glycoprotein IIIa |
| CD36 | Relatively non-specific (seen in erythroid and monocytic leukaemias) but often strongly expressed
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