Flow cytometry:AUL

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Acute Undifferentiated Leukaemia (AUL): diagnosis

To diagnose acute undifferentiated leukaemia the cells need to meet specific criteria, and possible alternatives should be excluded. These are given in the table below:

Requirement 1

Lineage can be assigned by lineage-defining markers of any lineage Lineage defining myeloid markers should not be expressed Review criteria for myeloid-lineage assgnment Lineage defining B-lymphoid markers should not be expressed Review criteria for B-lymphoid lineage assgnment Lineage defining T-lymphoid markers should not be expressed Review criteria for T-lymphoid lineage assgnment

Requirement 2

Ensure that other conditions that may resemble undifferentiated acute leukaemia are excluded: particularly consider whether marker patterns suggest any of the following: acute megakaryocytic leukaemia Non haematopoietic tumours Blastic plasma dendritic cell neoplasm Plasma cell leukaemia

Requirement 3

Consider whether the case may be better described as Acute Leukaemia of Ambiguous Lineage - not otherwise specified (ALAL-NOS) - see guidance Acute leukaemia of ambiguous lineage, not otherwise specified

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