Flow cytometry:AUL: Difference between revisions
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|colspan="1" style = "font-size:90%; color:black; background:# | |colspan="1" style = "font-size:90%; color:black; background:#a3c2c2"|'''Acute Undifferentiated Leukaemia (AUL): diagnosis''' | ||
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< | To diagnose acute undifferentiated leukaemia the cells need to meet specific criteria, and possible alternatives should be excluded. These are given in the table below:</br></br></span> | ||
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|colspan="2" style = "font-size:90%; color:black; background:#e6f7ff" |'''Requirement 1''' | |||
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|colspan="2" style = "font-size:90%; color:black; | |colspan="2" style = "font-size:90%; color:black;"|It is not possible to definitely assign any lineage using accepted criteria</br></br>Myeloid lineage cannot be assigned [[Flow Cytometry:Myeloid lineage assignment|(review criteria)]]</br>Lineage defining B-lymphoid markers should not be expressed [[Flow Cytometry:B-lymphoid lineage assignment|Review criteria for B-lymphoid lineage assgnment]]</br>Lineage defining T-lymphoid markers should not be expressed [[Flow Cytometry:T-Lymphoid lineage assignment|Review criteria for T-lymphoid lineage assgnment]] | ||
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|colspan="2" style = "font-size:90%; color:black; background:LightBlue" |'''Requirement 2''' | |||
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|colspan="2" style = "font-size:90%; color:black;"|Ensure that other conditions that may resemble undifferentiated acute leukaemia are excluded: particularly consider whether marker patterns suggest any of the following: | |colspan="2" style = "font-size:90%; color:black;"|Ensure that other conditions that may resemble undifferentiated acute leukaemia are excluded: particularly consider whether marker patterns suggest any of the following: | ||
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*[[Plasma cell leukaemia]] | *[[Plasma cell leukaemia]] | ||
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|colspan="2" style = "font-size:90%; color:black; background: | |colspan="2" style = "font-size:90%; color:black; background:LightBlue" |'''Requirement 3''' | ||
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|colspan="2" style = "font-size:90%; color:black;"|Consider whether the case may be better described as Acute Leukaemia of Ambiguous Lineage - not otherwise specified (ALAL-NOS) - see guidance | |colspan="2" style = "font-size:90%; color:black;"|Consider whether the case may be better described as Acute Leukaemia of Ambiguous Lineage - not otherwise specified (ALAL-NOS) - see guidance | ||
Latest revision as of 14:01, 18 January 2024
| Acute Undifferentiated Leukaemia (AUL): diagnosis |
To diagnose acute undifferentiated leukaemia the cells need to meet specific criteria, and possible alternatives should be excluded. These are given in the table below:
| Requirement 1 | |
| It is not possible to definitely assign any lineage using accepted criteria Myeloid lineage cannot be assigned (review criteria) Lineage defining B-lymphoid markers should not be expressed Review criteria for B-lymphoid lineage assgnment Lineage defining T-lymphoid markers should not be expressed Review criteria for T-lymphoid lineage assgnment | |
| Requirement 2 | |
| Ensure that other conditions that may resemble undifferentiated acute leukaemia are excluded: particularly consider whether marker patterns suggest any of the following: | |
| Requirement 3 | |
| Consider whether the case may be better described as Acute Leukaemia of Ambiguous Lineage - not otherwise specified (ALAL-NOS) - see guidance |