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Flow cytometry:AUL: Difference between revisions

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Revision as of 13:47, 18 January 2024



Acute Undifferentiated Leukaemia (AUL): diagnosis


To diagnose acute undifferentiated leukaemia the cells need to meet specific criteria, and possible alternatives should be excluded. These are given in the table below:

Requirement 1
It is not possible to any lineage using accepted criteria

Myeloid lineage cannot be assigned (review criteria)
Lineage defining B-lymphoid markers should not be expressed Review criteria for B-lymphoid lineage assgnment
Lineage defining T-lymphoid markers should not be expressed Review criteria for T-lymphoid lineage assgnment
Requirement 2
Ensure that other conditions that may resemble undifferentiated acute leukaemia are excluded: particularly consider whether marker patterns suggest any of the following:
Requirement 3
Consider whether the case may be better described as Acute Leukaemia of Ambiguous Lineage - not otherwise specified (ALAL-NOS) - see guidance