Flow cytometry:AUL: Difference between revisions
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|colspan="2" style = "font-size:90%; color:black;"|Lineage can be assigned by lineage-defining markers of any lineage</br></br> | |colspan="2" style = "font-size:90%; color:black;"|Lineage can be assigned by lineage-defining markers of any lineage</br></br> | ||
Lineage defining myeloid markers should not be expressed [[Flow Cytometry:Myeloid lineage assignment|Review criteria for myeloid-lineage assgnment]] | Lineage defining myeloid markers should not be expressed [[Flow Cytometry:Myeloid lineage assignment|Review criteria for myeloid-lineage assgnment]] | ||
Lineage defining B-lymphoid markers should not be expressed [[Flow Cytometry:B-lymphoid lineage assignment|Review criteria for B-lymphoid lineage assgnment]] | |||
Lineage defining T-lymphoid markers should not be expressed [[Flow Cytometry:T-Lymphoid lineage assignment|Review criteria for T-lymphoid lineage assgnment]] | |||
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|colspan="2" style = "font-size:90%; color:black; background:LightBlue" |'''Requirement 2''' | |colspan="2" style = "font-size:90%; color:black; background:LightBlue" |'''Requirement 2''' | ||
Revision as of 00:59, 18 January 2024
| Acute Undifferentiated Leukaemia (AUL): diagnosis |
To diagnose acute undifferentiated leukaemia the cells need to meet specific criteria, and possible alternatives should be excluded. These are given in the table below:
| Requirement 1 | |
| Lineage can be assigned by lineage-defining markers of any lineage Lineage defining myeloid markers should not be expressed Review criteria for myeloid-lineage assgnment Lineage defining B-lymphoid markers should not be expressed Review criteria for B-lymphoid lineage assgnment Lineage defining T-lymphoid markers should not be expressed Review criteria for T-lymphoid lineage assgnment | |
| Requirement 2 | |
| Ensure that other conditions that may resemble undifferentiated acute leukaemia are excluded: particularly consider whether marker patterns suggest any of the following: | |
| Requirement 3 | |
| Consider whether the case may be better described as Acute Leukaemia of Ambiguous Lineage - not otherwise specified (ALAL-NOS) - see guidance |