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Flow cytometry:AUL: Difference between revisions

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|colspan="2" style = "font-size:90%; color:black; background:LightBlue" |'''Requirement 1'''
|colspan="2" style = "font-size:90%; color:black; background:LightBlue" |'''Requirement 1'''
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|colspan="2" style = "font-size:90%; color:black;"|No lineage can be assigned by lineage-defining markers of myeloid, B-lymphoid or T-lymphoid lineage
|colspan="2" style = "font-size:90%; color:black;"|Lineage can be assigned by lineage-defining markers of any lineage</br></br>
Review Criteria:
Lineage defining myeloid markers should not be expressed [[Flow Cytometry:Myeloid lineage assignment|Review criteria for myeloid-lineage assgnment]]
*[[Flow Cytometry:Myeloid lineage assignment|Myeloid]]
*[[Flow Cytometry:B-lymphoid lineage assignment|B-Lymphoid]]
*[[Flow Cytometry:B-lymphoid lineage assignment|B-Lymphoid]]
*[[Flow Cytometry:T-Lymphoid lineage assignment|T-Lymphoid]]
*[[Flow Cytometry:T-Lymphoid lineage assignment|T-Lymphoid]]

Revision as of 00:56, 18 January 2024



Acute Undifferentiated Leukaemia (AUL): diagnosis


To diagnose acute undifferentiated leukaemia the cells need to meet specific criteria, and possible alternatives should be excluded. These are given in the table below:

Requirement 1
Lineage can be assigned by lineage-defining markers of any lineage

Lineage defining myeloid markers should not be expressed Review criteria for myeloid-lineage assgnment

Requirement 2
Ensure that other conditions that may resemble undifferentiated acute leukaemia are excluded: particularly consider whether marker patterns suggest any of the following:
Requirement 3
Consider whether the case may be better described as Acute Leukaemia of Ambiguous Lineage - not otherwise specified (ALAL-NOS) - see guidance