CD41

Summary

A reliable and specific marker that can be used to identify megakaryocyte lineage characteristics.

Background

• CD41 and CD61 respectively represent the alpha or beta chains that together form the IIbIIIa receptor that mediates the binding of activated platelets to fibrinogen during platelet aggregation.

Diagnostic Use

• The alpha IIb only forms part of this receptor and therefore has very good specificity for identifying megakaryocytic differentiation

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