CD10: Difference between revisions
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(Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD10 is expressed early pre-B ALL ("common ALL"), but also has wide expression on all subtypes notably also being expressed by Burkitt lymphoma and many cases of T-ALL :CD10 is also found on normal developing B-lymphocytes (haematogones) so is found very frequently in regenerating marrows :In mature lymphoproliferative...") |
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:CD10 is expressed early pre-B ALL ("common ALL"), but also has wide expression on all subtypes notably also being expressed by Burkitt lymphoma and many cases of T-ALL | :CD10 is expressed early pre-B ALL ("common ALL"), but also has wide expression on all subtypes notably also being expressed by Burkitt lymphoma and many cases of T-ALL | ||
:CD10 is also found on normal developing B-lymphocytes (haematogones) so is found very frequently | :CD10 is also found on normal developing B-lymphocytes (haematogones) so is found very frequently on B-cell precursor cells regenerating marrows | ||
:In mature lymphoproliferative disorders CD10 is consistently expressed by follicular lymphoma, but this is not fully specific and the marker may (rarely) be found on other lymphoproliferative cell types. | :In mature lymphoproliferative disorders CD10 is consistently expressed by follicular lymphoma, but this is not fully specific and the marker may (rarely) be found on other lymphoproliferative cell types. | ||
Revision as of 13:25, 7 May 2023
- Summary
- CD10 is expressed early pre-B ALL ("common ALL"), but also has wide expression on all subtypes notably also being expressed by Burkitt lymphoma and many cases of T-ALL
- CD10 is also found on normal developing B-lymphocytes (haematogones) so is found very frequently on B-cell precursor cells regenerating marrows
- In mature lymphoproliferative disorders CD10 is consistently expressed by follicular lymphoma, but this is not fully specific and the marker may (rarely) be found on other lymphoproliferative cell types.
Normal expression and function
CD10 inactivates small peptide hormones but function varies with different roles within the lymphoid and myeloid systems. CD10 For lymphoid cells expression of CD10 broadly correlates with periods of proliferation so it is expressed from the early pre-B cell stage then is lost as B cells leave the bone marrow before becoming re-acquired by B cells within the reactive germinal centres - secondary follicles . In contrast within the myeloid system CD10 is expressed on mature neutrophils but not maturing myeloid cells.
Diagnostic role
- xxxxx
Other relevant information:
xxxxx
SUMMARY TABLES
Note The colour and % refer to the proportion of cases expressing the marker. Additional comments on strength, or site of expression (if relevant) are given below the table. For full details of key click here. For further information about a particular disease state click <I> adjacent to the condition name
Expression in primitive cell types | |||||||
---|---|---|---|---|---|---|---|
AML | CMML | B ALL | Burkitt | T ALL | ETP ALL <I> | MPAL <I> | Hgns <I> |
? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx
Expression in mature B cell neoplasms | |||||||
---|---|---|---|---|---|---|---|
CLL | MCL | FL | MZL | HCL | DLBCL | LPL | PCL |
? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx
Expression in mature T cell neoplasms* | ||||||
---|---|---|---|---|---|---|
ATLL | CTCL/Sezary | T-PLL | T-LGL | NK-LGL | ||
? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx