Additional immunophenotypic markers useful in lineage assignment or subtyping of AML: Difference between revisions
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|colspan="1" style = "font-size:84%;"|This marker is most associated with monocytic maturation in AML being fairly well corellated with CD11B, but overall probably less specific for monocytic differentiation that CD14 | |colspan="1" style = "font-size:84%;"|This marker is most associated with monocytic maturation in AML being fairly well corellated with CD11B, but overall probably less specific for monocytic differentiation that CD14 | ||
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!colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:lightgrey">|'''3. Additional markers Features associated with erythroid differentiation'''</span><span style="font-size:90%; text-align:left; background:white"> | |||
|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |'''3. Features associated with erythroid differentiation''' | |colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |'''3. Features associated with erythroid differentiation''' | ||
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!colspan="2" style = "font-size:90%;background:white;"| | !colspan="2" style = "font-size:90%;background:white;"|Most often AML with erythroid maturation will express [[CD34]], while [[CD45]] and [[HLA-DR]] are weak or negative. [[CD117]] and [[CD36]] are generally expressed. There may be some expression of platelet markers in some cases. | ||
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD71]]''' | |colspan="1" style = "font-size:90%; color:black;" |'''[[CD71]]''' | ||
Revision as of 18:12, 20 December 2023
Table: Marker patterns that can contribute to diagnosis or subtyping in less common cases
| 1. Additional markers that may support granulocytic maturation | |||
|---|---|---|---|
| Standard markers in AML generally allow assignment for granulocytic cases, other markers may be less specific | |||
| CD11b | A marker of both granulocytic and monocytic maturation, this marker has previously been associated with less good outcome in a number of studies | ||
| 2. Additional markers that may support monocytic maturation | |||
| Standard markers in AML generally allow assignment for granulocytic cases, other markers may be less specific | |||
| Addtional features of monocytic differentiation | |||
| CD11c | This marker is most associated with monocytic maturation in AML being fairly well corellated with CD11B, but overall probably less specific for monocytic differentiation that CD14 | ||
| 3. Additional markers Features associated with erythroid differentiation | 3. Features associated with erythroid differentiation | ||
| Most often AML with erythroid maturation will express CD34, while CD45 and HLA-DR are weak or negative. CD117 and CD36 are generally expressed. There may be some expression of platelet markers in some cases. | |||
| CD71 | Frequently expressed though not fully lineage specific | ||
| CD235 | A good marker of erythroid differentiation but acquired late and therefore may not be expressed | ||
| point 4 | |||
| Features associated with megakaryocytic differentiation | |||
| Most often CD34, CD45 and HLA-DR are weak or negative, although CD13 and CD33 may be expressed | |||
| CD41 | Platelet glycoprotein IIbIIIa | ||
| CD61 | Platelet glycoprotein IIIa | ||
| CD36 | Relatively non-specific (seen in erythroid and monocytic leukaemias) but often strongly expressed
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