Additional immunophenotypic markers useful in lineage assignment or subtyping of AML: Difference between revisions
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'''Table: Marker patterns that | '''Table: Marker patterns that can contribute to diagnosis or subtyping in less common cases''' | ||
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!colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:pale gray">|Myeloid lineage-associated markers (Specific differentiation)'''</span><span style="font-size:90%; text-align:left; background:white"> | !colspan="2" <span style="font-size:100%; colour:white; text-align:left; border: 1px solid black; background:pale gray">|Myeloid lineage-associated markers (Specific differentiation)'''</span><span style="font-size:90%; text-align:left; background:white"> | ||
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|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" | | |colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |Generally the standard lineage-defining or lineage-associated markers in AML will allow assignment of granulocytic cases, other markers may be less specific but occasionally useful. | ||
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!colspan="2" style = "font-size:90%;background:white;"|Additional features of granulocytic maturation | !colspan="2" style = "font-size:90%;background:white;"|Additional features of granulocytic maturation | ||
Revision as of 18:01, 20 December 2023
Table: Marker patterns that can contribute to diagnosis or subtyping in less common cases
| Myeloid lineage-associated markers (Specific differentiation) | |
|---|---|
| Generally the standard lineage-defining or lineage-associated markers in AML will allow assignment of granulocytic cases, other markers may be less specific but occasionally useful. | |
| Additional features of granulocytic maturation | |
| CD11b | A marker of both granulocytic and monocytic maturation, this marker has previously been associated with less good outcome in a number of studies |
| point 2 | |
| Addtional features of monocytic differentiation | |
| CD11c | This marker is most associated with monocytic maturation in AML being fairly well corellated with CD11B, but overall probably less specific for monocytic differentiation that CD14 |
| CD14 | Primarily a marker of monocytic maturation in AML, seen most often in more differentiated forms, when present CD14 be considered a strong indicator of monocytic phenotype. |
| CD64 | A good lineage marker for monocytic differentiation in AML, expressed in both monoblastic and monocytic forms, not fully sepicific when expressed at lower levels. |
| point 3 | |
| Features associated with erythroid differentiation | |
| Most often CD34, CD45 and HLA-DR are weak or negative, although CD117 and CD36 are generally expressed. There may be some expression of platelet markers in some cases. | |
| CD71 | Frequently expressed though not fully lineage specific |
| CD235 | A good marker of erythroid differentiation but acquired late and therefore may not be expressed |
| point 4 | |
| Features associated with megakaryocytic differentiation | |
| Most often CD34, CD45 and HLA-DR are weak or negative, although CD13 and CD33 may be expressed | |
| CD41 | Platelet glycoprotein IIbIIIa |
| CD61 | Platelet glycoprotein IIIa |
| CD36 | Relatively non-specific (seen in erythroid and monocytic leukaemias) but often strongly expressed
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