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  • 21:05, 12 May 2023 John talk contribs created page CD23 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span> <span style="font-...")
  • 20:32, 11 May 2023 John talk contribs created page CD4 & CD8 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :'''Systemic disease:''' On T lymphocytes these two co-stimulatory molecules define different functional types; an altered ratio between CD4 and CD8 cells can indicate systemic disease or immune dysfunction :'''Neoplasia:''' Expanded populations of CD4 or CD8 cells (or T cells with unusual expression patterns of these molecules) may represent a malignant clone, and the CD4...")
  • 15:53, 10 May 2023 John talk contribs created page CD61 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
  • 15:53, 10 May 2023 John talk contribs created page CD43 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
  • 15:52, 10 May 2023 John talk contribs created page CD41 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxxx </div> :<span style="color:navy">'''Background'''</span> :xxxxxx :<span style="color:navy">'''Diagnostic Use'''</span> *xxxxx -----")
  • 12:43, 9 May 2023 John talk contribs created page CD22 (Created page with "CD22 expression is largely restricted to b cell lineage and expression is acquired at an early differentiation stage. *expression varies during mature b-cell development however the major value of CD22 lies in the identification of all based on high lineage-specificity and very early acquisition allowing the identification of pro-b all. normal expression and function CD22 is a membrane receptor that binds sialic acid containing glycans and expression is mostly rest...")
  • 23:16, 8 May 2023 John talk contribs created page CD1a (Created page with "A T cell marker that has value in specific circumstances Background CD1a is structurally related to major histocompatibility complex proteins and is thought to mediate the presentation of lipid and glycolipid antigens. CD1a expression is absent on very early thymocytes, but is acquired together with CD4 and CD8 as T cells develop in the thymus, then is lost in mature T cells. Diagnostic Use :A marker of early T-lineage :CD1A us useful in the identification of some cas...")
  • 21:58, 8 May 2023 John talk contribs created page CD19 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span> <span style="font-...")
  • 13:23, 7 May 2023 John talk contribs created page CD10 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD10 is expressed early pre-B ALL ("common ALL"), but also has wide expression on all subtypes notably also being expressed by Burkitt lymphoma and many cases of T-ALL :CD10 is also found on normal developing B-lymphocytes (haematogones) so is found very frequently in regenerating marrows :In mature lymphoproliferative...")
  • 14:13, 6 May 2023 John talk contribs created page CD2 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :CD2 is a pan t-cell marker. In diagnostic use it may be less reliable than CD3 for identification of T-cell lineage, since loss of CD2 expression is seen in some peripheral T-cell lymphomas, and aberrant expression in AML is recognised (particularly the APL subtype). </div> <span style="color:navy">'''Normal expressi...")
  • 12:44, 6 May 2023 John talk contribs created page Extra (Created page with "CD14 aids recognition of bacteria by cells of monocytic lineage. it may generally be regarded as a pan-monocyte antigen when expressed in aml CD14 is a marker of monocytic lineage absence of CD14 expression does not preclude monocytic lineage since some typical monoblasts do not express this marker CD14 is not restricted to malignant cells and will be expressed by reactive monocytes and also by neoplastic cells of cmml normal expression and function together...")
  • 11:59, 6 May 2023 John talk contribs created page CD14 (Created page with "(259, 'cd14', ' cd14 aids recognition ofu800 bacteria byu800 cells ofu800 monocytic lineage. itu800 mayu800 generally beu800 regarded asu800 au800 panu800-monocyte antigen * when expressed inu800 amlu800 cd14 isu800 au800 marker ofu800 monocytic lineage * absence ofu800 cd14 expression does notu800 preclude monocytic lineage since some typical monoblasts dou800 notu800 express this marker * cd14 isu800 notu800 restricted tou800 malignant cells andu800 will beu800 express...")
  • 22:57, 3 May 2023 John talk contribs created page CD79a (Created page with "<span style="color:navy">'''''DETAILS'''''</span> CD38 helps mobilise intracellular calcium to activate a wide array of cell functions. In haematological cell types CD38 it is widely expressed by lymphoid cells )B, T and NK) as well as myeloid precursor cells and mature myeloid cells. It has particular diagnostic importance for lymphocytes where CD38 expression is acquired as stem cells commit to B-cell lineage, then is lost as mature B cells emerge from bone marrow be...")
  • 14:10, 3 May 2023 John talk contribs created page Key to marker expression table (Created page with " <span style="font-size:80%">'''''1. Colour key:''''' ''- the likelihood of any individual case expressing this marker, indicated by colour:'' </span> {| class=wikitable style="text-align: left; font-size:80%; width: 60%; height: 30px; |style= "width: 16.6%; background: #FFE4E1; |Few reported studies (though likely rare) |} {| class=wikitable style="text-align: left; font-size:80%; width:60%; height: 30px; |style= "width: 16.6%; background: #E6FAFF; |Expression may b...")
  • 15:28, 1 May 2023 John talk contribs created page CD4 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :'''Systemic disease:''' On T lymphocytes these two co-stimulatory molecules define different functional types; an altered ratio between CD4 and CD8 cells can indicate systemic disease or immune dysfunction :'''Neoplasia:''' Expanded populations of CD4 or CD8 cells (or T cells with unusual expression patterns of these molecules) may represent a malignant clone, and the CD4...")
  • 10:21, 1 May 2023 John talk contribs created page CD11c (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span>")
  • 20:51, 30 April 2023 John talk contribs created page CD3 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span>")
  • 17:10, 30 April 2023 John talk contribs created page CD5 (Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :'''For mature B cell neoplasms''': CD5 is used to indicate likely CLL or MCL. However, expression is present on a subset of normal B cells, and also less frequently on other lymphoma types. Full interpretation therefore requires consideration of clonality and other markers. :'''In acute lymphoblastic leukaemia''': CD5 is u...")
  • 10:24, 30 April 2023 John talk contribs created page CD45 (Created page with "<span style="color:navy">'''''SUMMARY TABLES'''''</span> {| class=wikitable style="text-align: center; font-size:80%; width: 100%; height 20px;" |- !colspan="7"|<span style="font-size:100%">'''CD13 expression: primitive cell types'''</font> |- ! AML !! B ALL !! Burkitt || T ALL !! ETP ALL ('''i''') !! MPAL '''i || Hgns '''i''' |- |style="width: 14.25%; background: #FFE4E1 #FFE4E1 #66e0ff #00b8e6 #006699; color:white"|Limited Rare Possible...")
  • 13:46, 26 April 2023 John talk contribs created page CD38 (Created page with " <span style="color:navy">'''''DETAILS'''''</span> CD38 helps initiate the mobilsation of intracellular calcium, activating a wide array of cell functions that depend on cell type. In haematological cell types CD38 is widely expressed by lymphoid cells and by particular myeloid cells – often in a stage-specific manner. For B lymphocytes CD38 expression is acquired as stem cells commit to B-cell lineage, then lost as mature B cells emerge from bone marrow before be...")
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