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Revision as of 13:03, 12 July 2023
Background to flow cytometric diagnosis
This is an uncommon diagnosis by flow cytometry as DLBCL cells generally circulate and involve bone marrow only at only a late stage in disease (ofetn when a diagnosis has already been made). However, occasionally these cases can present as a new diagnosis by blood or marrow and can be difficult as marker expression is often variable between cases.
| Immunophenotype of DLBCL | |||
|---|---|---|---|
| Major markers useful in CLL diagnosis | |||
| Marker | Freq | Level | Comment |
| CD19 | - | ||
| κ/λ | - | ||
| CD5 | - | ||
| CD23 | - | Characteristic of CLL, although can rarely be weak or absent | |
| CD79b | wk | Expression is expected, but characteristically weak | |
| CD200 | - | Characteristically positive in CLL and negative in MCL | |
| FMC7 | May be expressed by atypical cases, generally absent | ||
| Other relevant markers | |||
| CD10 | - | ||
| CD11C | - | ||
| CD20 | - | ||
| CD25 | - | ||
| CD38 | - | ||
| CD43 | - | ||
| CD103 | - | ||
| CD138 | - | ||
Key to table:
Key to colour code for expression frequency Click for link
Key to expression strength code and use Click for link