Test: Difference between revisions
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|colspan="1" style = "width: 6%; background:#00b8e6;"| | |colspan="1" style = "width: 6%; background:#00b8e6;"| | ||
|colspan="1" style = "width: 4%; |wk | |colspan="1" style = "width: 4%; |wk | ||
|colspan="1" style = "font-size: | |colspan="1" style = "font-size:84%;"|Either weak restricted κ or λ or undetectable expression | ||
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|colspan="1" style = "width: 6%; font-size:90%;" |'''CD19''' | |colspan="1" style = "width: 6%; font-size:90%;" |'''CD19''' | ||
|colspan="1" style = "width: 6%; background:#004466;"| | |colspan="1" style = "width: 6%; background:#004466;"| | ||
|colspan="1" style = "width: 4%; font-size:90%;"|Wk/ mod | |colspan="1" style = "width: 4%; font-size:90%;"|Wk/ mod | ||
|colspan="1" style = "font-size: | |colspan="1" style = "font-size:84%;"|Expression is expected, but less strong than normal B cells | ||
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Revision as of 19:24, 16 June 2023
Background
Typical CLL can be diagnosed with some confidence using flow cytometry. CLL cells express low levels of B-cell receptor associated molecules (e.g. CD19, CD79B and sIg) together with CD5 and CD23 in typical cases. However, atypical cases are regularly encoutered and can cause diagnosic difficulty.
| Immunophenotype of CLL | |||
|---|---|---|---|
| Major markers useful in CLL diagnosis | |||
| κ/λ | wk | Either weak restricted κ or λ or undetectable expression | |
| CD19 | Wk/ mod | Expression is expected, but less strong than normal B cells | |
Pitfalls and atypical cases