Table of frequent aberrant markers in AML

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The key point is that AML will frequently express immunological markers not typically associated with myeloid lineage. Broadly, the abberant expression may include:

Markers of primitive phenotype that are more frequently associated with lymphoid disorders, This is aknowledged in diagnostic criteria and providing diagnostic criteria are applied they do not require a changed diagnosis. The most frequent "abberencies" observed in AML are:

(1) The expression of CD7 by nearly half of cases
(2) The expression of CD19, often associated with particular AML subtypes

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CD19 BCRABL TdT 7%

Markers associated with lymphoid maturation that may also be expressed by the lineage maturation, particularly monocytic lineage CD2 CD4, 36 38 MONOCYTIC 5%

BASOPHILIC 123, 203, 11B 22

Frequent abberant markers in AML that are often associated with genetic/cytogenetic subtype: CD19 30% CBF RUNX1, BCRABL CD56 CBF RUNX1 NPM1 OFTEN LACK CD34