TDT: Difference between revisions
From haematologyetc.co.uk
(Created page with " <div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em; margin-right: 5px;"> :<span style="color:navy">'''Summary'''</span> :xxxx </div> <span style="color:navy">'''Normal expression and function'''</span> xxxxx <span style="color:navy">'''Diagnostic role'''</span> *xxxxx <span style="color:navy">'''Other relevant information:'''</span> xxxxx ---- <span style="color:navy">'''''SUMMARY TABLES'''''</span> <span style="font-...") |
No edit summary |
||
| Line 5: | Line 5: | ||
:<span style="color:navy">'''Summary'''</span> | :<span style="color:navy">'''Summary'''</span> | ||
: | :Terminal Deoxynucleotidyl Transferase (TdT) a nuclear cell protein whose detection therefore requires cells to be permeabilised for detection by flow cytometry. Expression is usual in acute lymphoblastic leukaemias, but TdT is also commonly also found in acute myeloid leukaemia so is not fully specific (Tdt is also strongly expressed by early regenerating B-lymphocytes (haematogones). Since expression of TdT is retricted to immature cells TdT expression can help distinguish between primative and mature B cells. | ||
Revision as of 16:07, 18 May 2023
- Summary
- Terminal Deoxynucleotidyl Transferase (TdT) a nuclear cell protein whose detection therefore requires cells to be permeabilised for detection by flow cytometry. Expression is usual in acute lymphoblastic leukaemias, but TdT is also commonly also found in acute myeloid leukaemia so is not fully specific (Tdt is also strongly expressed by early regenerating B-lymphocytes (haematogones). Since expression of TdT is retricted to immature cells TdT expression can help distinguish between primative and mature B cells.
Normal expression and function
xxxxx
Diagnostic role
- xxxxx
Other relevant information:
xxxxx
SUMMARY TABLES
Note The colour and % refer to the proportion of cases expressing the marker. Additional comments on strength, or site of expression (if relevant) are given below the table. For full details of key click here. For further information about a particular disease state click <I> adjacent to the condition name
| Expression in primitive cell types | |||||||
|---|---|---|---|---|---|---|---|
| AML | CMML | B ALL | Burkitt | T ALL | ETP ALL <I> | MPAL <I> | Hgns <I> |
| ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx
| Expression in mature B cell neoplasms | |||||||
|---|---|---|---|---|---|---|---|
| CLL | MCL | FL | MZL | HCL | DLBCL | LPL | PCL |
| ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx
| Expression in mature T cell neoplasms* | ||||||
|---|---|---|---|---|---|---|
| ATLL | CTCL/Sezary | T-PLL | T-LGL | NK-LGL | ||
| ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ||
Notes: xxxxx