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Recognition of blast cells with monocytic differentiation: Difference between revisions

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<div id="AML_MonoPic">'''Recognition of blast cells with monocytic differentiation'''</div>


[[Image:AMLM5A.jpg|130px|caption]] '''A''' monoblastic AML
<div id="AML_MonoPic"><span style="font-size:90%;">'''Recognition of blast cells with monocytic differentiation'''</span></div>
[[Image:AMLM5B.jpg|130px|caption]] '''B''' monocytic AML


<span style="font-size:90%">
[[Image:AMLM5A.jpg|130px|caption]]<span style="font-size:90%;"> '''A''' monoblastic AML</span>
*'''Panel A''': Where cells have a monoblastic differentiation (generally large blast cells with primitive chromatin and nucleoli that lack ''monocytic shape'' often with basophilic cytoplasm) the monoblasts tend to express markers of primitive phenotype, while typical antigens of monocytic differentiation may be variable or weakly expressed.
[[Image:AMLM5B.jpg|130px|caption]]<span style="font-size:90%;"> '''B''' monocytic AML</span>
*'''Panel B''': Where cells undergo more appreciable monocytic differentiation (note the more condensed chromatin, lack of nucleolus, and ''monocytic shape'' of there nucleus) these cells tend to have stronger CD45 expression and often express typical monocyte antigens, primitive markers may be variably expressed or absent.
*Mixed patterns of monoblastic monocytic and myeloid differentiation within the same case are also frequently found.


:''Correlation of immunophenotype with morphology and clinical features may be necessary to accurately identify such cells as blasts.''
<span style="font-size:90%">'''Panel A''': Where cells have a monoblastic differentiation (generally large blast cells with primitive chromatin and nucleoli that lack ''monocytic shape'' often with basophilic cytoplasm) the monoblasts tend to express markers of primitive phenotype, while typical antigens of monocytic differentiation may be variable or weakly expressed.'''Panel B''': Where cells undergo more appreciable monocytic differentiation (note the more condensed chromatin, lack of nucleolus, and ''monocytic shape'' of there nucleus) these cells tend to have stronger CD45 expression and often express typical monocyte antigens, primitive markers may be variably expressed or absent.</br></br>*Mixed patterns of monoblastic monocytic and myeloid differentiation within the same case are also frequently found. </br>''Correlation of immunophenotype with morphology and clinical features may be necessary to accurately identify such cells as blasts.''
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Latest revision as of 19:14, 2 February 2024




Recognition of blast cells with monocytic differentiation

caption A monoblastic AML caption B monocytic AML

Panel A: Where cells have a monoblastic differentiation (generally large blast cells with primitive chromatin and nucleoli that lack monocytic shape often with basophilic cytoplasm) the monoblasts tend to express markers of primitive phenotype, while typical antigens of monocytic differentiation may be variable or weakly expressed.Panel B: Where cells undergo more appreciable monocytic differentiation (note the more condensed chromatin, lack of nucleolus, and monocytic shape of there nucleus) these cells tend to have stronger CD45 expression and often express typical monocyte antigens, primitive markers may be variably expressed or absent.

*Mixed patterns of monoblastic monocytic and myeloid differentiation within the same case are also frequently found.
Correlation of immunophenotype with morphology and clinical features may be necessary to accurately identify such cells as blasts.