Recognition of APL differentiation: Difference between revisions
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(Created page with " <div id="AML_AplPic">'''Recognition of acute promyelocytic leukaemia'''</div> 130px <span style="font-size:90%">Typical APL has cells that are hypergranular (A) or may be the microgranular variant (B) generally the cells will have a range of granulation or nuclear appearance. While CD45 expression tends to be weak, in almost all cases the variable morphological features cause a wide range of side-scatter with the abnormal cells often forming a...") |
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<span style="font-size:90%">'''Recognition of acute promyelocytic leukaemia'''</span> | |||
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Latest revision as of 00:15, 12 January 2024
Recognition of acute promyelocytic leukaemia
Typical APL has cells that are hypergranular (A) or may be the microgranular variant (B) generally the cells will have a range of granulation or nuclear appearance. While CD45 expression tends to be weak, in almost all cases the variable morphological features cause a wide range of side-scatter with the abnormal cells often forming a "cloud" extending toward the neutrophil area. This can make the cells (particular hypergranular forms) difficult to distinguish from reactive myeloid populations (or occasionally from MDS). Absent HLA-DR on APL cells can help distinguish from reactive cells (expressing HLA-DR), but correlation with morphology and clinical features and other confirmatory tests are essential to the recognition of APL.