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<span style="color: navy>'''Background'''</span>


Typical CLL can be diagnosed with some confidence using flow cytometry.
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{| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0"
However, individual markers may not be expressed in all cases - this can cause diagnostic difficulty particularly in distinguishing CLL from atypical cases of MCL or MZL. If this is the case then the atypical features should be reported, and the possibility of alternative diagnoses acknowledged.
!colspan="4" style = "font-size:100%; color: navy; text-align:center; background:#DEE0DE;"|'''Immunophenotype LPD'''
 
Note also that cases with a low lymphocytosis (<1x10<sup>9</sup>) may represent monoclonal B-lymphocytosis with CLL phenotype [[Monoclonal B lymphocytosis|(click here for more)]].
 
 
 
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{| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="5"
!colspan="4" style = "font-size:110%; color: navy; text-align:center; background:#DEE0DE;"|'''Immunophenotype LPD'''
|-
|-
|colspan="1" style = "font-size:80%; width: 15%; |'''Marker'''
|colspan="1" style = "font-size:80%; width: 60%; |'''Marker'''
|colspan="1" style = "font-size:80%; width: 5%; |'''CLL'''
|colspan="1" style = "font-size:80%; width: 20%; |'''CLL'''
|colspan="1" style = "font-size:80%; width: 20%; |'''MCL'''
|-
|-
|colspan="1" style = "width: 4%; font-size:90%; color:navy;" |<u>'''κ/λ'''</u>
|colspan="1" style = "font-size:90%; color:navy;" |'''κ/λ'''
|colspan="1" style = "width: 8%; background:#00b8e6;"|wk
|colspan="1" style = "background:#00b8e6;"|wk
|colspan="1" style = "width: 8%; background:#004466;"|
|-
|-
|colspan="1" style = "font-size:90%; color:navy;" |<u>'''FMC7'''</u>
|colspan="1" style = "font-size:90%; color:navy;" |'''FMC7'''
|colspan="1" style = "background:#66e0ff;"|
|colspan="1" style = "background:#66e0ff;"|
|colspan="1" style = "background:#006699;"|
|-
|-
|colspan="1" style = "font-size:90%; color:navy;" |<u>'''CD5'''</u>
|colspan="1" style = "font-size:90%;" |'''CD5'''
|colspan="1" style = "background:#004466;"|
|colspan="1" style = "background:#004466;"|
|colspan="1" style = "background:#004466;"|
|-
|-
|colspan="1" style = "font-size:90%;" |CD10
|colspan="1" style = "font-size:90%;" |CD10
|colspan="1" style = "background:#00b8e6;"|
|colspan="1" style = "background:#00b8e6;"|
|colspan="1" style = "background:#00b8e6;"|
|-
|-
|colspan="1" style = "font-size:90%;" |CD11C
|colspan="1" style = "font-size:90%;" |CD11C
|colspan="1" style = "background:#00b8e6;"|
|colspan="1" style = "background:#00b8e6;"|
|colspan="1" style = "background:#00b8e6;"|
|-
|-
|colspan="1" style = "font-size:90%; color:navy;" |<u>'''CD19'''</u>
|colspan="1" style = "font-size:90%; color:navy;" |'''CD19'''
|colspan="1" style = "background:#004466;"|
|colspan="1" style = "background:#004466;"|
|colspan="1" style = "background:#004466;"|
|-
|-
|colspan="1" style = "font-size:90%;" |CD20
|colspan="1" style = "font-size:90%;" |CD20
|colspan="1" style = "background:#004466;"|
|colspan="1" style = "background:#004466;"|
|colspan="1" style = "background:#004466;"|
|-
|-
|colspan="1" style = "font-size:90%; color:navy;" |<u>'''CD23'''</u>
|colspan="1" style = "font-size:90%; color:navy;" |'''CD23'''
|colspan="1" style = "background:#004466;"|
|colspan="1" style = "background:#004466;"|
|colspan="1" style = "background:#00b8e6;"|
|-
|-
|colspan="1" style = "font-size:90%; color:black;" |CD25
|colspan="1" style = "font-size:90%; color:black;" |CD25
|colspan="1" style = "background:#00b8e6;"|wk
|colspan="1" style = "background:#00b8e6;"|wk
|colspan="1" style = "background:#00b8e6;"|
|-
|-
|colspan="1" style = "font-size:90%; color:black;" |CD38
|colspan="1" style = "font-size:90%; color:black;" |CD38
|colspan="1" style = "background:#66e0ff;"|
|colspan="1" style = "background:#66e0ff;"|
|colspan="1" style = "background:#004466;"|
|-
|-
|colspan="1" style = "font-size:90%;" |CD43
|colspan="1" style = "font-size:90%;" |CD43
|colspan="1" style = "background:#004466;"|
|colspan="1" style = "background:#004466;"|
|colspan="1" style = "background:#00b8e6;"|
|-
|-
|colspan="1" style = "font-size:90%; color:navy;" |<u>'''CD79a'''</u>
|colspan="1" style = "font-size:90%; color:black;" |'''CD79a'''
|colspan="1" style = "background:#004466;"|wk
|colspan="1" style = "background:#004466;font-size:90%; color:white"|wk
|colspan="1" style = "background:#004466;"|
|-
|-
|colspan="1" style = "font-size:90%;" |CD103
|colspan="1" style = "font-size:90%;" |CD103
|colspan="1" style = "background:#E6FAFF;"|
|colspan="1" style = "background:#E6FAFF;"|
|colspan="1" style = "background:#E6FAFF;"|
|-
|-
|colspan="1" style = "font-size:90%;" |CD138
|colspan="1" style = "font-size:90%;" |CD138
|colspan="1" style = "background:#E6FAFF;"|
|colspan="1" style = "background:#E6FAFF;"|
|colspan="1" style = "background:#E6FAFF;"|
|-
|-
|colspan="1" style = "font-size:90%; color:navy;" |<u>'''CD200'''</u>
|colspan="1" style = "font-size:90%; color:navy;" |'''CD200'''
|colspan="1" style = "background:#004466;"|
|colspan="1" style = "background:#004466;"|
|colspan="1" style = "background:#E6FAFF;"|
|-
|-
|}
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<span style="color:navy;font-size:80% ">'''Key to table: '''</span>
<span style="color:navy;font-size:80% ">'''Key to table: '''</span>


<span style="font-size:80% ">Markers most useful in initial diagnosis are <span style=color:navy><u>underlined in blue text</u></span></span>


<span style="font-size:80% ">Key to colour code for expression frequency [[Key_to_marker_expression_table|Click for link]]</span>
<span style="font-size:80% ">Key to colour code [[Key_to_marker_expression_table|Click for link]]</span>


<span style="font-size:80% ">Key to expression strength code and use [[Expression strength key|Click for link]]</span>
<span style="font-size:80% ">Key to expression code [[Expression strength key|Click for link]]</span>






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Latest revision as of 12:33, 21 June 2023

Immunophenotype LPD
Marker CLL MCL
κ/λ wk
FMC7
CD5
CD10
CD11C
CD19
CD20
CD23
CD25 wk
CD38
CD43
CD79a wk
CD103
CD138
CD200

Key to table:


Key to colour code Click for link

Key to expression code Click for link


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