Myeloid lineage-associated markers: Difference between revisions
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'' | ''These markers can be used to identify myeloid lineage. They allow the diagnosis of AML if there are no lineage-defining markers of B-lineage or T-lineage. Alternatively, if lineage-defining markers of B-lineage or T-lineage are present then consider a diagnosis of MPAL''</br></br> | ||
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|colspan="2" style = "font-size:90%; color:black; background:lightgrey" |''' | |colspan="2" style = "font-size:90%; color:black; background:lightgrey" |'''Assignment of myeloid lineage: Lineage-associated markers''' | ||
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|colspan="2" style = "font-size:90%; color:black; background:#ddeee1"| | |colspan="2" style = "font-size:90%; color:black; background:#ddeee1"|Myeloid lineage assignment using these markers requires that at least two myeloid lineage-associated markers are present | ||
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|colspan="1" style = "font-size:90%; color:black;" |'''[[CD117]]''' | |colspan="1" style = "font-size:90%; color:black;" |'''[[CD117]]''' | ||
Latest revision as of 19:57, 5 January 2024
These markers can be used to identify myeloid lineage. They allow the diagnosis of AML if there are no lineage-defining markers of B-lineage or T-lineage. Alternatively, if lineage-defining markers of B-lineage or T-lineage are present then consider a diagnosis of MPAL
| Assignment of myeloid lineage: Lineage-associated markers | |
| Myeloid lineage assignment using these markers requires that at least two myeloid lineage-associated markers are present | |
| CD117 | An early marker of myeloid lineage, seen in up to 80% of AML and vauable in recognising more primitive differentaiion forms (note that aberrant expression is seen in up to 20% of ALL cases) |
| CD33 | A good marker for AML, particularly for those cases with granulocytic maturation, CD33 is often less strongly expressed in AML with monocytic dfferentiation and strongly expressed in APL. |
| CD13 | A good lineage marker for AML that is acquired a little later in differentation than CD117 or CD33; expression of CD13 is often higher than CD33 in AML with monocytic differentiation. |