Myeloid lineage-associated markers: Difference between revisions
From haematologyetc.co.uk
No edit summary |
No edit summary |
||
| Line 7: | Line 7: | ||
---- | ---- | ||
These markers can be used to identify myeloid lineage. They allow the diagnosis of AML if there are no lineage-defining markers of B-lineage or T-lineage. Alternatively, if lineage-defining markers of B-lineage or T-lineage are present then consider diagnosis of MPAL.</br> | These markers can be used to identify myeloid lineage. They allow the diagnosis of AML if there are no lineage-defining markers of B-lineage or T-lineage. Alternatively, if lineage-defining markers of B-lineage or T-lineage are present then consider diagnosis of MPAL.</br></br> | ||
<div style="width: 95%"> | <div style="width: 95%"> | ||
{| class="wikitable" style="border-style: solid; border-width: 5px; color:black" | {| class="wikitable" style="border-style: solid; border-width: 5px; color:black" | ||
Revision as of 19:56, 5 January 2024
These markers can be used to identify myeloid lineage. They allow the diagnosis of AML if there are no lineage-defining markers of B-lineage or T-lineage. Alternatively, if lineage-defining markers of B-lineage or T-lineage are present then consider diagnosis of MPAL.
| Assignment of myeloid lineage: Lineage-associated markers | |
| Myeloid lineage assignment using these markers requires that at least two myeloid lineage-associated markers are present | |
| CD117 | An early marker of myeloid lineage, seen in up to 80% of AML and vauable in recognising more primitive differentaiion forms (note that aberrant expression is seen in up to 20% of ALL cases) |
| CD33 | A good marker for AML, particularly for those cases with granulocytic maturation, CD33 is often less strongly expressed in AML with monocytic dfferentiation and strongly expressed in APL. |
| CD13 | A good lineage marker for AML that is acquired a little later in differentation than CD117 or CD33; expression of CD13 is often higher than CD33 in AML with monocytic differentiation. |