MPAL: Difference between revisions
From haematologyetc.co.uk
(Created page with "<span id="anchor_0"></span>. <div style="width: 100%; border: 1px solid black; font-size:100%"> {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" !colspan="2" <span style="font-size:90%; font-color:navy; text-align:center; border: 1px solid black; background:pale gray">|'''MARKERS USEFUL TO CONFIRM PRIMITIVE NATURE OF BLAST CELLS'''</br></span> |- |colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |'''Useful mark...") |
No edit summary |
||
Line 2: | Line 2: | ||
<div style="width: 100%; border: 1px solid black; font-size:100%"> | <div style="width: 100%; border: 1px solid black; font-size:100%"> | ||
{| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" | {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="0" | ||
!colspan="2" <span style="font-size:90%; font-color:navy; text-align:center; border: 1px solid black; background:pale gray">|''' | !colspan="2" <span style="font-size:90%; font-color:navy; text-align:center; border: 1px solid black; background:pale gray">|'''Definition of MPAL (WHO) Section 1 - defining Myeloid lineage'''</br></span> | ||
|- | |- | ||
|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |''' | |colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |'''Marker combination 1''' | ||
<div class="mw-collapsible mw-collapsed" data-expandtext="Click for explanation" data-collapsetext="Hide explanation"> | <div class="mw-collapsible mw-collapsed" data-expandtext="Click for explanation" data-collapsetext="Hide explanation"> | ||
<div class="mw-collapsible-content"> | <div class="mw-collapsible-content"> |
Revision as of 18:54, 26 July 2023
.
Definition of MPAL (WHO) Section 1 - defining Myeloid lineage | |
---|---|
Marker combination 1
(1) Typically AML blasts have low CD45 expression and cause low side scatter. This means that they form a relatively uniform and distinctive population that is clearly separate from that of lymphocytes on CD45/SSc plots (for further details see this section). It is important to realise however also not all AML cases may fit this pattern low CD45/low SSc pattern - particularly APL and monocytic AML. | |
CD45 | A marker expressed by all leukocytes and their precursors. In AML expression is characteristically "weak" i.e. significantly less intense than normal lymphocytes or monocytes. In monocytic AML expression may be stronger. |
CD34 | Frequently expressed by AML blast cells (40-80% of cases) - most often in less differentiated forms of AML. Expression is also seein frequently (and often more strongly) in ALL |
Other markers that may be associated with primitive nature in AML | |
In the context of a proven AML diagnosis a number of markers may be expressed that are considered to predominantly reflect their primitive nature. Some of these are more frequently associated with lymphoid disorders, but providing other criteria for AML are met their presence does not change lineage assignment. These include TDT, CD7, other? |