Immnophenotypic markers in AML

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Table: Marker patterns that allow definite diagnosis of acute myeloid leukaemia;
Pattern 1: A myeloid lineage-defining marker pattern is present and No lineage-defining markers of T or B cells are present.
MPO is the only "lineage-defining" marker of AML
MPO	MPO is expressed in around 80% of cases of AML and in the absence of any other lineage defining features detection of MPO expression allows a diagnosis of AML to be made (see notes).
Pattern 2: At least two myeloid lineage-associated markers are present and There are no lineage defining markers of T or B cells and No more than one T-cell or B-cell lineage-associated marker is present
CD117	An early marker of myeloid lineage, seen in up to 80% of AML and vauable in recognising more primitive differentaiion forms (note that aberrant expression is seen in up to 20% of ALL cases)
CD33	A good marker for AML, particularly for those cases with granulocytic maturation, CD33 is often less strongly expressed in AML with monocytic dfferentiation and strongly expressed in APL.
CD13	A good lineage marker for AML that is acquired a little later in differentation than CD117 or CD33; expression of CD13 is often higher than CD33 in AML with monocytic differentiation.

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