Flow cytometry:MPAL: Difference between revisions
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:<span style="font-size:90%;">MPAL with t(v;11q23.3); with KMT2A re-arrangement</span></br> | :<span style="font-size:90%;">MPAL with t(v;11q23.3); with KMT2A re-arrangement</span></br> | ||
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Mixed phenotype or biphenotypic and blast cell number | |||
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<span style="font-size:90%>To diagnose MPAL, the leukaemia should meet '''at least two of the three criteria''' below: | <span style="font-size:90%>To diagnose MPAL, the leukaemia should meet '''at least two of the three criteria''' below: |
Revision as of 19:55, 8 January 2024
Mixed Phenotype Acute Leukaemia (MPAL) |
MPAL is uncommon (2-3% of acute leukaemia). Flow cytometry provides initial evidence of MPAL. However conclusions may subsequently be modified (e.g. by results of immunohistochemistry, cytogenetics, or genetics). It is important that the provisional nature of flow cytometry assignment of MPAL is acknowledged.
Types and frequency of MPAL types
(1) MPAL with features of Myeloid and B-lineage (MPAL M/B) (>50% cases)
(2) MPAL with features of Myeloid and T-lineage (MPAL M/T) (>33% cases)
(3) MPAL with combinations: MPAL B/T (rare) or B/T/M (very rare)
(4) Following further analysis cases may be assigned additionally as:
- MPAL with t(9;22) (q34.1;q11.2); BCR-ABL1;
- MPAL with t(v;11q23.3); with KMT2A re-arrangement
Mixed phenotype or biphenotypic and blast cell number
To diagnose MPAL, the leukaemia should meet at least two of the three criteria below:
.
Criteria to assign myeloid lineage | |
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The case has lineage-defining features of myeloid maturation. This allows myeloid lineage to be defined in MPAL Click here to review criteria for myeloid lineage assignment based on lineage-defining features Note: myeloid-associated lineage markers cannot be contribute to myeloid lineage assignment in MPAL. | |
Criteria to assign B-lymphoid lineage | |
Click here to review criteria for B-lymphoid lineage assignment | |
Criteria to assign T-lymphoid lineage | |
Click here to review criteria for T-lymphoid lineage assignment |
Consider also: