Flow cytometry:MPAL: Difference between revisions
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!colspan="2" style = "font-size:90%; color:black; background:light-grey" |'''Criteria to assign myeloid lineage''' | !colspan="2" style = "font-size:90%; color:black; background:light-grey" |'''Criteria to assign myeloid lineage''' | ||
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|colspan="2" style = "font-size:90%; color:black;"|The case has lineage defining features of myeloid maturation. This allows myeloid lineage to be defined in MPAL</br>[[Flow Cytometry:Myeloid lineage assignment|Click here to review criteria for myeloid lineage assignment]] | |colspan="2" style = "font-size:90%; color:black;"|The case has '''lineage-defining features''' of myeloid maturation. This allows myeloid lineage to be defined in MPAL</br>[[Flow Cytometry:Myeloid lineage assignment|Click here to review criteria for myeloid lineage assignment based on lineage-defining features]]</br> | ||
|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |Criteria to assign B-lymphoid lineage | |colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |Criteria to assign B-lymphoid lineage | ||
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Revision as of 17:44, 8 January 2024
| Mixed Phenotype Acute Leukaemia (MPAL) |
MPAL is uncommon (2-3% of acute leukaemia). Flow cytometry provides initial evidence of MPAL. However conclusions may subsequently be modified (e.g. by results of immunohistochemistry, cytogenetics, or genetics). It is important that the provisional nature of flow cytometry assignment of MPAL is acknowledged.
Types and frequency of MPAL types
(1) MPAL with features of Myeloid and B-lineage (MPAL M/B) (>50% cases)
(2) MPAL with features of Myeloid and T-lineage (MPAL M/T) (>33% cases)
(3) MPAL with combinations: MPAL B/T (rare) or B/T/M (very rare)
(4) Following further analysis cases may be assigned additionally as:
- MPAL with t(9;22) (q34.1;q11.2); BCR-ABL1;
- MPAL with t(v;11q23.3); with KMT2A re-arrangement
To diagnose MPAL, the leukaemia should meet at least two of the three criteria below:
.
| Criteria to assign myeloid lineage | |||
|---|---|---|---|
| The case has lineage-defining features of myeloid maturation. This allows myeloid lineage to be defined in MPAL Click here to review criteria for myeloid lineage assignment based on lineage-defining features |
Criteria to assign B-lymphoid lineage | ||
| Click here to review criteria for B-lymphoid lineage assignment | |||
| Criteria to assign T-lymphoid lineage | |||
| Click here to review criteria for T-lymphoid lineage assignment |
Consider also: