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Flow cytometry:MPAL: Difference between revisions

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'''Types and frequency of MPAL types'''
'''Types and frequency of MPAL types'''


(1) MPAL with features of Myeloid and B-lineage (MPAL M/B) (>50% cases)
(1) MPAL with features of Myeloid and B-lineage (MPAL M/B) (>50% cases)</br>
(2) MPAL with features of Myeloid and T-lineage (MPAL M/T) (>33% cases)
(2) MPAL with features of Myeloid and T-lineage (MPAL M/T) (>33% cases)</br>
(3) MPAL with combinations: MPAL B/T (rare) or B/T/M (very rare)
(3) MPAL with combinations: MPAL B/T (rare) or B/T/M (very rare)</br>
(4) Following further analysis cases may be assigned additionally as:
(4) Following further analysis cases may be assigned additionally as:</br>
<span style="font-size:90%;">MPAL with t(9;22) (q34.1;q11.2); BCR-ABL1; </span>  
<span style="font-size:90%;">MPAL with t(9;22) (q34.1;q11.2); BCR-ABL1; </span></br>  
<span style="font-size:90%;">MPAL with t(v;11q23.3); with KMT2A re-arrangement</span>
<span style="font-size:90%;">MPAL with t(v;11q23.3); with KMT2A re-arrangement</span></br>
 
<div style="width: 95%"; font-size:90%>
{| class="wikitable"
!colspan="2" style = "background:lightgrey; font-size:90%; border:solid"| '''Types and frequency''' MPAL mixed-phenotype forms
|-
!colspan="1" style = "background:#FFFFF0;border:solid; font-size:90%;"| MPAL with features of Myeloid and B-lineage (MPAL M/B)
!colspan="1" style = "background:white;border:solid; font-size:90%;"| This is the most common MPAL (more than 50% of MPAL cases).
|-
!colspan="1" style = "background:#FFFFF0;border:solid"| MPAL with features of Myeloid and T-lineage (MPAL M/T)
!colspan="1" style = "background:white; border:solid; font-size:90%;"| The second most frequent form (over one third of MPAL cases).
|-
!colspan="1" style = "background:#FFFFF0;border:solid"| MPAL with combinations: MPAL B/T (rare) or B/T/M (very rare)
!colspan="1" style = "background:white; border:solid; font-size:90%;"| These forms are infrequent (around 10% of MPAL cases)
|-
!colspan="1" style = "background:#FFFFF0;border:solid"| MPAL with defining molecular features
!colspan="1" style = "background:white; border:solid; font-size:90%;"| Following further analysis cases may be assigned additionally as:</br>
<span style="font-size:90%;">MPAL with t(9;22) (q34.1;q11.2); BCR-ABL1; </span>  
<span style="font-size:90%;">MPAL with t(v;11q23.3); with KMT2A re-arrangement</span>
|}
</div>
 


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Revision as of 10:55, 5 January 2024

Mixed Phenotype Acute Leukaemia (MPAL)

Important Note

MPAL is uncommon (2-3% of acute leukaemia). Flow cytometry provides initial evidence of MPAL. However conclusions may subsequently be modified (e.g. by results of immunohistochemistry, cytogenetics, or genetics). It is important that the provisional nature of flow cytometry assignment of MPAL is acknowledged.

Types and frequency of MPAL types

(1) MPAL with features of Myeloid and B-lineage (MPAL M/B) (>50% cases)
(2) MPAL with features of Myeloid and T-lineage (MPAL M/T) (>33% cases)
(3) MPAL with combinations: MPAL B/T (rare) or B/T/M (very rare)
(4) Following further analysis cases may be assigned additionally as:
MPAL with t(9;22) (q34.1;q11.2); BCR-ABL1;
MPAL with t(v;11q23.3); with KMT2A re-arrangement

‎.

To diagnose MPAL, the leukaemia should meet at least two of the three criteria below
Criteria to assign myeloid lineage
Click here to review criteria for myeloid lineage assignment
Criteria to assign B-lymphoid lineage
Click here to review criteria for B-lymphoid lineage assignment
Criteria to assign T-lymphoid lineage
Click here to review criteria for T-lymphoid lineage assignment
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