Flow cytometry:MPAL: Difference between revisions
From haematologyetc.co.uk
No edit summary |
No edit summary |
||
| Line 35: | Line 35: | ||
---- | ---- | ||
---- | ---- | ||
<span id="anchor_0"></span>. | <span id="anchor_0"></span>. | ||
| Line 62: | Line 42: | ||
!colspan="2" <span style="font-size:90%; font-color:navy; style="text-align: left; border: 1px solid black; background:pale gray">|To diagnose MPAL, the leukaemia should meet '''at least two of the three criteria''' below</br></span> | !colspan="2" <span style="font-size:90%; font-color:navy; style="text-align: left; border: 1px solid black; background:pale gray">|To diagnose MPAL, the leukaemia should meet '''at least two of the three criteria''' below</br></span> | ||
|- | |- | ||
|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" | | |colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |Criteria to assign myeloid lineage | ||
|- | |- | ||
|colspan="2" style = "font-size:90%; color:black;"|[[Flow Cytometry:Myeloid lineage assignment|Click here to review criteria for myeloid lineage assignment]] | |colspan="2" style = "font-size:90%; color:black;"|[[Flow Cytometry:Myeloid lineage assignment|Click here to review criteria for myeloid lineage assignment]] | ||
|- | |- | ||
|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" | | |colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |Criteria to assign B-lymphoid lineage | ||
|- | |- | ||
|colspan="2" style = "font-size:90%; color:black;"|[[Flow Cytometry:B-lymphoid lineage assignment|Click here to review criteria for B-lymphoid lineage assignment]] | |colspan="2" style = "font-size:90%; color:black;"|[[Flow Cytometry:B-lymphoid lineage assignment|Click here to review criteria for B-lymphoid lineage assignment]] | ||
|- | |- | ||
|colspan="2" style = "font-size:90%; color:black; background:#ddeee1" | | |colspan="2" style = "font-size:90%; color:black; background:#ddeee1" |Criteria to assign T-lymphoid lineage | ||
|- | |- | ||
|colspan="2" style = "font-size:90%; color:black;"|[[Flow Cytometry:T-Lymphoid lineage assignment|Click here to review criteria for T-lymphoid lineage assignment]] | |colspan="2" style = "font-size:90%; color:black;"|[[Flow Cytometry:T-Lymphoid lineage assignment|Click here to review criteria for T-lymphoid lineage assignment]] | ||
Revision as of 19:29, 23 December 2023
Important Note
MPAL is uncommon (2-3% of acute leukaemia). Flow cytometry provides initial evidence of MPAL. However conclusions may subsequently be modified (e.g. by results of immunohistochemistry, cytogenetics, or genetics). It is important that the provisional nature of flow cytometry assignment of MPAL is acknowledged.
| Types and frequency MPAL mixed-phenotype forms | |
|---|---|
| MPAL with features of Myeloid and B-lineage (MPAL M/B) | This is the most common MPAL (more than 50% of MPAL cases). |
| MPAL with features of Myeloid and T-lineage (MPAL M/T) | The second most frequent form (over one third of MPAL cases). |
| MPAL with combinations: MPAL B/T (rare) or B/T/M (very rare) | These forms are infrequent (around 10% of MPAL cases) |
| MPAL with defining molecular features | Following further analysis cases may be assigned additionally as: MPAL with t(9;22) (q34.1;q11.2); BCR-ABL1; MPAL with t(v;11q23.3); with KMT2A re-arrangement |
.
| To diagnose MPAL, the leukaemia should meet at least two of the three criteria below | |
|---|---|
| Criteria to assign myeloid lineage | |
| Click here to review criteria for myeloid lineage assignment | |
| Criteria to assign B-lymphoid lineage | |
| Click here to review criteria for B-lymphoid lineage assignment | |
| Criteria to assign T-lymphoid lineage | |
| Click here to review criteria for T-lymphoid lineage assignment |