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| |} | | |} |
| </div>
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| <div style="width: 20%; overflow: auto; border: 1px solid navy; font-size:100%">
| |
| {| class="wikitable" style="color:black; background-color:#ffffff;" cellpadding="5"
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| !colspan="4" style = "font-size:110%; color: navy; text-align:center; background:#DEE0DE;"|'''Immunophenotype of CLL'''
| |
| |-
| |
| !colspan="4" style = "font-size:90%; background:#DAE8F2"|'''Major markers useful in CLL diagnosis'''
| |
| |-
| |
| |colspan="1" style = "font-size:80%; width: 15%; |'''Marker'''
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| |colspan="1" style = "font-size:80%; width: 5%; |'''CLL'''
| |
| |-
| |
| |colspan="1" style = "width: 4%; font-size:90%; color:navy;" |<u>'''κ/λ'''</u>
| |
| |colspan="1" style = "width: 8%; background:#00b8e6;"|wk
| |
| |-
| |
| |colspan="1" style = "font-size:90%; color:navy;" |<u>'''FMC7'''</u>
| |
| |colspan="1" style = "background:#66e0ff;"|
| |
| |-
| |
| |colspan="1" style = "font-size:90%; color:navy;" |<u>'''CD5'''</u>
| |
| |colspan="1" style = "background:#004466;"|
| |
| |-
| |
| |colspan="1" style = "font-size:90%;" |CD10
| |
| |colspan="1" style = "background:#00b8e6;"|
| |
| |-
| |
| |colspan="1" style = "font-size:90%;" |CD11C
| |
| |colspan="1" style = "background:#00b8e6;"|
| |
| |-
| |
| |colspan="1" style = "font-size:90%; color:navy;" |<u>'''CD19'''</u>
| |
| |colspan="1" style = "background:#004466;"|
| |
| |-
| |
| |colspan="1" style = "font-size:90%;" |CD20
| |
| |colspan="1" style = "background:#004466;"|
| |
| |-
| |
| |colspan="1" style = "font-size:90%; color:navy;" |<u>'''CD23'''</u>
| |
| |colspan="1" style = "background:#004466;"|
| |
| |-
| |
| |colspan="1" style = "font-size:90%; color:black;" |CD25
| |
| |colspan="1" style = "background:#00b8e6;"|wk
| |
| |-
| |
| |colspan="1" style = "font-size:90%; color:black;" |CD38
| |
| |colspan="1" style = "background:#66e0ff;"|
| |
| |-
| |
| |colspan="1" style = "font-size:90%;" |CD43
| |
| |colspan="1" style = "background:#004466;"|
| |
| |-
| |
| |colspan="1" style = "font-size:90%; color:navy;" |<u>'''CD79a'''</u>
| |
| |colspan="1" style = "background:#004466;"|wk
| |
| |-
| |
| |colspan="1" style = "font-size:90%;" |CD103
| |
| |colspan="1" style = "background:#E6FAFF;"|
| |
| |-
| |
| |colspan="1" style = "font-size:90%;" |CD138
| |
| |colspan="1" style = "background:#E6FAFF;"|
| |
| |-
| |
| |colspan="1" style = "font-size:90%; color:navy;" |<u>'''CD200'''</u>
| |
| |colspan="1" style = "background:#004466;"|
| |
| |-
| |
| |}
| |
| </div>
| |
|
| |
|
|
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|
Background
Typical CLL can be diagnosed with some confidence using flow cytometry.
However, individual markers may not be expressed in all cases - this can cause diagnostic difficulty particularly in distinguishing CLL from atypical cases of MCL or MZL. If this is the case then the atypical features should be reported, and the possibility of alternative diagnoses acknowledged.
Note also that cases with a low lymphocytosis (<1x109) may represent monoclonal B-lymphocytosis with CLL phenotype (click here for more).
| Immunophenotype of CLL
|
| Major markers useful in CLL diagnosis
|
| Marker
|
CLL
|
| κ/λ
|
wk
|
| FMC7
|
|
| CD5
|
|
| CD10
|
|
| CD11C
|
|
| CD19
|
|
| CD20
|
|
| CD23
|
|
| CD25
|
wk
|
| CD38
|
|
| CD43
|
|
| CD79a
|
wk
|
| CD103
|
|
| CD138
|
|
| CD200
|
|
Key to table:
Markers most useful in initial diagnosis are underlined in blue text
Key to colour code for expression frequency Click for link
Key to expression strength code and use Click for link