Extra

Summary

Normal expression and function

Diagnostic role

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SUMMARY TABLES

Note The colour and % refer to the proportion of cases expressing the marker. Additional comments on strength, or site of expression (if relevant) are given below the table. For full details of key click here. For further information about a particular disease state click <I> adjacent to the condition name

Expression in primitive cell types
AML	CMML	B ALL	Burkitt	T ALL	ETP ALL <I>	MPAL <I>	Hgns <I>
5-20%*	<5%	80-100%**	80-100%	<5%	<5%	40-80%	80-100%

Notes: **While a good marker of B lineage it may not be expressed in more primitive phenotype ALL, there is also a recognised abberrant expression in AML (particularly cases with t)8;21)

Expression in mature B cell neoplasms
CLL	MCL	FL	MZL	HCL	DLBCL	LPL	PCL
80-100%*	80-100%	80-100%	80-100%**	80-100%**	40-80%	80-100%	5-20%***

Notes: Level of expression is important: *low expression in CLL; **typically high expression in HCL; ***generally absent in PCs

Expression in mature T cell neoplasms*
ATLL	CTCL/Sezary	T-PLL	T-LGL	NK-LGL
<5%	<5%	<5%	<5%	<5%

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summary tables

1. expression by acute leukaemias and by haematogones file freq pro-b all hi early pre-b all hi pre-b all hi early b all rare pro-t all rare mature-t all rare aml * hi haemato-gones

2. expression by b-lymphoproliferative disorders hi cll * hi pll** hi mcl hi fl hi hcl** hi hclv hi mzl poss lpl rare pcs

• typically weak ** typically strong