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Summary

Although CD15 is expressed in a range of haematological cell types, the main practical use for the marker is in the recognition of cells that have granulocytic or monocytic features. For this reason CD15 has a role in lineage distinction in AML. CD15 was originally described as the Lewis blood group antigen: Sialyl Lewis X. Deficiency of CD15 causes the clinical disorder Leukocyte Adhesion Deficiency Type 2.

Background

CD15 is a carbohydrate important in the initial phases of cell-to-cell adhesion known in this context as e-selectin .

Diagnostic Use

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