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CD7', ' *CD7 may be regarded as a pan t-cell marker that is useful for identifying t cells from very early stages of maturation however the high frequency of aberrant expression of CD7 means that caution is required in itsu8e28099 interpretation *variation of expression of CD7 by mature t cells can have diagnostic value in particular there is frequentl loss of CD7 expression in many cases of su8c3a9zary syndrome details CD7 is a transmembrane protein that supports t-cell b-cell interactions during lymphoid development. expression is acquired during thymic development of t cells appearing before other t-lineage markers and is retained by mature t cells. * very consistent expression by t-all from an early pro-t stage of maturation. however expression is seen frequently also in aml 30 and may occur in b-all * loss of CD7 expression occurs in mycosis fungoides and su8c3a9zary syndrome and can contribute to diagnosis * quantitative expression of CD7 is seen with high levels of expression in t-all and t-pll but lower in atll and lgl disorders