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CD43 sialophorin has a wide range of expression that includes t lymphocytes monocytes and granulocytes. CD43 is expressed by many normal activated b lymphocytes but expression is absent from resting B cells. Diagnostically the vlaue of CD43 relates to its variable expression between B lymphocyte neoplasms. usage

• CD43 expression in CLL is 95% including atypical CLL cases while in MCL it is expressed by around 40% of cases.
• this gives it some value in diagnosing cases of atypical CLL
• however CD43 is probably less useful than CD200 for distinguishing CLL and MCL.
• CD43 is rarely expressed in follicular lymphoma.

note also in haematopathology CD43 is often considered as a t-cell associated marker because it is expressed by over 95 of thymocytes and peripheral blood t-cells. loss of CD43 is seen in wiskottu aldrich syndrome. ---- '),

'CD41', ' a reliable and specific marker that can be used to identify megakaryocyte lineage characteristics *CD41 and CD61 respectively represent the alpha or beta chains that together form the iibiiia receptor that allows activated platelets to bind fibrinogen and other adhesion proteins during platelet aggregation.

• CD41 the alpha iib only forms part of this receptor and therefore has good specificity for megakaryocytic differentiation ---- '),

'CD61', ' a marker of megakaryocytic lineage but also expressed by cells of monocyte macrophage lineage details *CD61 is the beta integrin beta iii chain of the platelet iibiiia adhesion receptor. *CD61 may therefore be regarded as a marker of megakaryocytic lineage. however when combined with an alternative alpha chain alpha v CD61 forms part of the vitronectin receptor. the vitronectin receptor is expressed on a range of cell types including cells of monocyte macrophage lineage. *therefore while both CD41 and CD61 have value in confirming a megakaryocytic differentiation in acute myeloid leukaemia the context of its expression is important for interpretation ---- '),