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:<span style="color:navy">'''Summary'''</span> | :<span style="color:navy">'''Summary'''</span> | ||
: | :CD79b is a pan-b-cell marker expressed from early commitment until plasma cell differentiation that may be used as marker of B-lineage, but it is generally less useful than CD79a or CD19 in this context | ||
:The major diagnostic value of CD79b is its characteristically weak-expression in CLL | |||
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<span style="color:navy">'''Normal expression and function'''</span> | <span style="color:navy">'''Normal expression and function'''</span> | ||
The forma of CD79 molecules (CD79a and CD79b) associate directly with the immunoglobulin chains controlling signalling from the B-cell receptor. Expression of both CD79a and CD79b is therefore acquired at early b-lymphocyte formation, initially in cytoplasm then membrane and persists until plasma cell differentiation. However, while both CD79a and CD79b may be considered pan B-cell antigens, expression of CD79b is acquired later and is lost earlier than for CD79a. | |||
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<span style="color:navy">'''Diagnostic role'''</span> | <span style="color:navy">'''Diagnostic role'''</span> | ||
* | *The most useful attribute of CD79b in diagnosis is its variable intensity of expression by neoplastic cells - in particular the weak intensity of expression of CD79b is often used as a diagnostic criteria for CLL | ||
Revision as of 11:25, 5 June 2023
- Summary
- CD79b is a pan-b-cell marker expressed from early commitment until plasma cell differentiation that may be used as marker of B-lineage, but it is generally less useful than CD79a or CD19 in this context
- The major diagnostic value of CD79b is its characteristically weak-expression in CLL
Normal expression and function
The forma of CD79 molecules (CD79a and CD79b) associate directly with the immunoglobulin chains controlling signalling from the B-cell receptor. Expression of both CD79a and CD79b is therefore acquired at early b-lymphocyte formation, initially in cytoplasm then membrane and persists until plasma cell differentiation. However, while both CD79a and CD79b may be considered pan B-cell antigens, expression of CD79b is acquired later and is lost earlier than for CD79a.
Diagnostic role
- The most useful attribute of CD79b in diagnosis is its variable intensity of expression by neoplastic cells - in particular the weak intensity of expression of CD79b is often used as a diagnostic criteria for CLL
SUMMARY TABLES
Note The colour and % refer to the proportion of cases expressing the marker. Additional comments on strength, or site of expression (if relevant) are given below the table. For full details of key click here. For further information about a particular disease state click <I> adjacent to the condition name
Expression in primitive cell types | |||||||
---|---|---|---|---|---|---|---|
AML | CMML | B ALL | Burkitt | T ALL | ETP ALL <I> | MPAL <I> | Hgns <I> |
? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx
Expression in mature B cell neoplasms | |||||||
---|---|---|---|---|---|---|---|
CLL | MCL | FL | MZL | HCL | DLBCL | LPL | PCL |
? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx
Expression in mature T cell neoplasms* | ||||||
---|---|---|---|---|---|---|
ATLL | CTCL/Sezary | T-PLL | T-LGL | NK-LGL | ||
? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% | ? <5% 5-20% 20-40% 40-80% 80-100% |
Notes: xxxxx