Extra: Difference between revisions

Revision as of 11:24, 5 June 2023

Summary

xxxx

Normal expression and function

xxxxx

Diagnostic role

xxxxx

Other relevant information:

xxxxx

SUMMARY TABLES

Note The colour and % refer to the proportion of cases expressing the marker. Additional comments on strength, or site of expression (if relevant) are given below the table. For full details of key click here. For further information about a particular disease state click <I> adjacent to the condition name

Expression in primitive cell types
AML	CMML	B ALL	Burkitt	T ALL	ETP ALL <I>	MPAL <I>	Hgns <I>
? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%

Notes: xxxxx

Expression in mature B cell neoplasms
CLL	MCL	FL	MZL	HCL	DLBCL	LPL	PCL
? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%

Notes: xxxxx

Expression in mature T cell neoplasms*
ATLL	CTCL/Sezary	T-PLL	T-LGL	NK-LGL
? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%	? <5% 5-20% 20-40% 40-80% 80-100%

Notes: xxxxx

@@ Line 5: / Line 5: @@
 :<span style="color:navy">'''Summary'''</span>
-:mu is the heavy chain element of IgM, and may be detected in the cytoplasm of early B cells. Membrane mu is present on mature B cells but following antigen encounter mu is generally replaced by other heavy chain types. Mu expression is used in the immunophenotypic sub-classification of ALL since cytoplasmic mu is acquired by pre-B cells then expressed on the cell surface of mature B-ALL (Burkitt lymphoma) together with surface light chain. Detection of either surface mu or light chain can therefore contribute to the identification of Bukitt lymphoma. The detection of cytoplasmic mu has value in the identification of pre-B ALL subtypes but can be done on bone marow trephine immunostaining.
+:xxxx
+</div>
+<span style="color:navy">'''Normal expression and function'''</span>
+xxxxx
+<span style="color:navy">'''Diagnostic role'''</span>
+*xxxxx
+<span style="color:navy">'''Other relevant information:'''</span>
+xxxxx
+----
-</div>
-:<span style="color:navy">'''Background'''</span>
+<span style="color:navy">'''''SUMMARY TABLES'''''</span>
+<span style="font-size:90%">'''Note''' The colour and % refer to the proportion of cases expressing the marker. Additional comments on strength, or site of expression (if relevant) are given below the table. For full details of key click [[Key to marker expression table|here]]. For further information about a particular disease state click <<span style="color:blue>'''I'''</span>> adjacent to the condition name</span>
+{| class=wikitable style="text-align: center; font-size:80%; width: 100%; height 20px;"
+|-
+!colspan="8"|<span style="font-size:100%">'''Expression in primitive cell types'''</font>
+|-
+! AML !! CMML !! B ALL !! Burkitt || T ALL !! ETP ALL <'''[[ETP ALL|I]]'''> !! MPAL <'''[[MPAL|I]]'''> || Hgns <'''[[Hgns|I]]'''>
+|-
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|-
+|}
+<span style="font-size:90%">'''Notes:''' xxxxx </span>
-Mu heavy chain together with kappa or lambda light chains forms the IgM immunoglobulin molecule. In mature b-cells that have not encountered IgM is the predominant immunoglobulin type that forms part of the B-cell receptor (BCR). During B cell development the immunoglobulin heavy chain mu appears first in the cytoplasm where it is associated with surrogate light chains (pre-b cell stage) then subsequently is expressed on the membrane combined with either kappa or lambda light chain in mature B cells. Following antigen encounter IgM is most frequently replaced by other heavy chain forms.
+{| class=wikitable style="text-align: center; font-size:80%; width: 100%; height 20px;"
+|-
+!colspan="8"|'''Expression in mature B cell neoplasms'''
+|-
+! CLL !! MCL !!FL!! MZL !! HCL !! DLBCL || LPL !! PCL
+|-
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 12.5%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|-
+|}
+<span style="font-size:90%">'''Notes:''' xxxxx </span>
-:<span style="color:navy">'''Diagnostic Use'''</span>
-The changing expression of the mu heavy chain has value in the classification of B-lineage ALL
-*cytoplasmic mu distinguishes pre-B ALL (mu expressed) from the more common early pre-B ALL (mu not expressed)
-*surface expression of mu is a feature of mature forms of ALL including Burkitt lymphoma (where surface light chains will also be detected)
-*In histopathology mu expression is used to establish B cell lymphoma type, particularly lymphoplasmacytoid lymphoma where strong cytoplasmic expression is expected.
+{| class=wikitable style="text-align: center; font-size:80%; width: 62.4%; height 40px;"
+|-
+!colspan="7"|'''Expression in mature T cell neoplasms*'''
+|-
+! ATLL !! CTCL/Sezary !! T-PLL !! T-LGL !! NK-LGL
+|-
+|style="width: 14.25%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 14.25%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 14.25%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 14.25%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|style="width: 14.25%; background: ?#FFE4E1 5#E6FAFF 20#66e0ff 40#00b8e6 80#006699;100#004466; color:white black"|? <5% 5-20% 20-40% 40-80% 80-100%
+|-
+|}
+<span style="font-size:90%">'''Notes:''' xxxxx </span>
------
+----

Extra: Difference between revisions

From haematologyetc.co.uk

Revision as of 11:24, 5 June 2023