Extra: Difference between revisions

Revision as of 16:55, 31 May 2023

Summary

CD20 is a component of the B-cell receptor and is therefore expressed by mature B-lymphocytes. In many ways its expression is similar to that of CD19; however CD20 expression is acquired slightly later in B cell development and may be retained by somr plasma cells.

Background

CD20 is expressed by B-cells at late developmental stages including expression by some plasma cells.

Diagnostic Use

CD20 is regarded as a pan-B-cell marker and may be useful in the diagnosis of mature B-cell types if other patterns are atypical
Low levels of CD20 expression may be helpful in the recognition of CLL (similar to CD19, CD79b and light-chains)
CD20 is the target of rituximab and other therapeutic antibodies so expression may be absent from neoplastic cells relapsing after treatment with these antibodies

@@ Line 5: / Line 5: @@
 :<span style="color:navy">'''Summary'''</span>
-:The major role for CD16 is to identify and classify LGL disorders, but CD16 may also e used to demonstrate myeloid lineage commitment in MPAL
+:CD20 is a component of the B-cell receptor and is therefore expressed by mature B-lymphocytes. In many ways its expression is similar to that of CD19; however CD20 expression is acquired slightly later in B cell development and may be retained by somr plasma cells.
-:CD16 the FCRiii receptor is a protein bound to the cell membrane by a gpi-link; the molecule binds the fc region of antibody to mediate antibody-dependent cellular cytotoxicity. In blood CD16 is expressed mainly on NK cells neutrophils and monocytes. In tissues it is expressed by macrophages and natural killer cells.
@@ Line 15: / Line 13: @@
 :<span style="color:navy">'''Background'''</span>
-In normal myeloid cells expression of CD16 is progressively acquired through maturation and is highly expressed by myelocytes and neutrophils, it is also expressed less strogly by eosinophils and monocytes. CD16 is strongly expressed by NK cells.
+CD20 is expressed by B-cells at late developmental stages including expression by some plasma cells.
 :<span style="color:navy">'''Diagnostic Use'''</span>
-* CD16 has has value in the assessment of LGL disorders: T-LGL cells have variable or absent expression of CD16, while in LGL proliferations of NK cells CD16 is usually expressed
+*CD20 is regarded as a pan-B-cell marker and may be useful in the diagnosis of mature B-cell types if other patterns are atypical
-*As a gpi-linked protein CD16 may be lost from granulocytes in PNH, although it is not generally used in PNH diagnosis
+*Low levels of CD20 expression may be helpful in the recognition of CLL (similar to CD19, CD79b and light-chains)
+*CD20 is the target of rituximab and other therapeutic antibodies so expression may be absent from neoplastic cells relapsing after treatment with these antibodies
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Extra: Difference between revisions

From haematologyetc.co.uk

Revision as of 16:55, 31 May 2023