Extra: Difference between revisions
From haematologyetc.co.uk
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:<span style="color:navy">'''Summary'''</span> | :<span style="color:navy">'''Summary'''</span> | ||
: | :The main practical use for CD15 is for the recognition of cells that have granulocytic or monocytic features. For this reason CD15 has a role in lineage distinction in AML. CD15 is however also expressed in a range of haematological cell types and was originally described as the Lewis blood group antigen: Sialyl Lewis X. | ||
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:<span style="color:navy">'''Background'''</span> | :<span style="color:navy">'''Background'''</span> | ||
:CD15 is a carbohydrate important in the initial phases of cell-to-cell adhesion known in this context as | :CD15 is a carbohydrate important in the initial phases of cell-to-cell adhesion known in this context as E-selectin. In normal cells CD15 is constitutively expressed by granulocytes and monocytes, but not by resting lymphocytes - although induced strongly following activation. Deficiency of CD15 causes the clinical disorder Leukocyte Adhesion Deficiency Type 2. | ||
:<span style="color:navy">'''Diagnostic Use'''</span> | :<span style="color:navy">'''Diagnostic Use'''</span> | ||
* | *In histopathology CD15 is important in the recognition of the Redd Sterberg cells of Hodgkin Lymphoma | ||
*CD15 is expressed by most cases of AML that have granulocytic or monocytic differentiation where expression may vary within the population. | |||
*CD15 should not however be regarded as an exclusive myeloid marker since it is expressed by some cases of CLL and ALL | |||
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Revision as of 09:56, 30 May 2023
- Summary
- The main practical use for CD15 is for the recognition of cells that have granulocytic or monocytic features. For this reason CD15 has a role in lineage distinction in AML. CD15 is however also expressed in a range of haematological cell types and was originally described as the Lewis blood group antigen: Sialyl Lewis X.
- Background
- CD15 is a carbohydrate important in the initial phases of cell-to-cell adhesion known in this context as E-selectin. In normal cells CD15 is constitutively expressed by granulocytes and monocytes, but not by resting lymphocytes - although induced strongly following activation. Deficiency of CD15 causes the clinical disorder Leukocyte Adhesion Deficiency Type 2.
- Diagnostic Use
- In histopathology CD15 is important in the recognition of the Redd Sterberg cells of Hodgkin Lymphoma
- CD15 is expressed by most cases of AML that have granulocytic or monocytic differentiation where expression may vary within the population.
- CD15 should not however be regarded as an exclusive myeloid marker since it is expressed by some cases of CLL and ALL