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From haematologyetc.co.uk
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*Significant populations expressing gd chains may indicate autoimmune or inflammaotory disease | *Significant populations expressing gd chains may indicate autoimmune or inflammaotory disease | ||
*γδ restriction or predominance may suggest a γδ lymphoma | |||
Absence of | *Absence of αβ or γδ is found in NK lineage disorders | ||
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Revision as of 21:23, 14 May 2023
- Summary
- The αβ TCR is the primary form in health accounting for around 95% of circulating T cells. Alteration of that normal expression pattern may suggest a neoplastic or inflammatory disorder
- Background
- The αβ chains expressed are expressed as part of the T-cell receptor (TCR) complex - these are the antigen recognising parts of the complex. T cells expressing this receptor are referred to as αβ T cells.
- Diagnostic Use
- Significant populations expressing gd chains may indicate autoimmune or inflammaotory disease
- γδ restriction or predominance may suggest a γδ lymphoma
- Absence of αβ or γδ is found in NK lineage disorders