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:<span style="color:navy">'''Background'''</span> | :<span style="color:navy">'''Background'''</span> | ||
: | :The αβ chains expressed are expressed as part of the T-cell receptor (TCR) complex - these are the antigen recognising parts of the complex. T cells expressing this receptor are referred to as αβ T cells. | ||
:<span style="color:navy">'''Diagnostic Use'''</span> | :<span style="color:navy">'''Diagnostic Use'''</span> | ||
* | *Significant populations expressing gd chains may indicate autoimmune or inflammaotory disease | ||
Gd restriction or predominance may suggest a gd lymphoma | |||
Absence of ab or gd is found in NK lineage disorders | |||
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Revision as of 21:20, 14 May 2023
- Summary
- The αβ TCR is the primary form in health accounting for around 95% of circulating T cells. Alteration of that normal expression pattern may suggest a neoplastic or inflammatory disorder
- Background
- The αβ chains expressed are expressed as part of the T-cell receptor (TCR) complex - these are the antigen recognising parts of the complex. T cells expressing this receptor are referred to as αβ T cells.
- Diagnostic Use
- Significant populations expressing gd chains may indicate autoimmune or inflammaotory disease
Gd restriction or predominance may suggest a gd lymphoma Absence of ab or gd is found in NK lineage disorders