Extra: Difference between revisions

Revision as of 20:57, 14 May 2023

Summary

The αβ TCR is the primary form in health accounting for around 95% of circulating T cells, alteration of that normal pattern may suggest a neoplastic or inflammatory disorder

Background

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Diagnostic Use

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-In the detection of haematological malignancy the purpose of detecting γδ T cells is to define particular T cell lymphomas, since αβ T cells strongly predominate in blood. Some care must be taken when small populations of γδ T cells are detected however, since these may arise in response to viral or other immune responses.
-TCR analysis is not generally helpful in indicating T-cell clonality since around 95% express of circulating T cells express αβ chains; the remaining 5% of T cells have gamma γδ. in tissues this can be different since the γδ T cells are more abundant in skin and intraepithelial areas. The receptors also reflect different functions:  αβ T cells behave as elements of the adaptive immune system while γδ cells have an innate immune function similar to NK cells.
+<div style="background-color: #E0EEEE; {{round corners}} padding: 2em 2em;  margin-right: 5px;">
-*A predominant population of γδ T cells circulate may indicate a clonal proliferation most commonly will be hepatosplenic gamma-delta T-cell lymphoma  or primary cutaneous t cell lymphoma (PTCL)
+:<span style="color:navy">'''Summary'''</span>
+:The αβ TCR is the primary form in health accounting for around 95% of circulating T cells, alteration of that normal pattern may suggest a neoplastic or inflammatory disorder
+</div>
+:<span style="color:navy">'''Background'''</span>
+:xxxxxx
+:<span style="color:navy">'''Diagnostic Use'''</span>
+*xxxxx
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Extra: Difference between revisions

From haematologyetc.co.uk

Revision as of 20:57, 14 May 2023