Actions

Extra: Difference between revisions

From haematologyetc.co.uk

No edit summary
No edit summary
Line 1: Line 1:
TCRgamma delta', ' the primary purpose of using TCR chain analysis is to detect the rare T gamma delta cells that define particular t cell lymphomas. since alpha  beta chains strongly predominate in blood testing is not generally helpful in indicating T-cell clonality each TCR comprises the complex of the CD3 molecules with two different protein chains. circulating human T cells in most cases around 95% express alpha beta chains; the remaining 5% of T cells have gamma delta chains. in tissues this can be different since the gamma delat T cells are more abundant in skin and intraepithelial areas. The receptors also reflect different function while alpha beta T cells behave as elements of the adaptive immune system gamma delta-t cells have an innate immune function similar to NK cells . *where predominantly gamma delta-t cells circulate this is an indicator of a clonal proliferation *precise disease type requires confirmation but most commonly will be hepatosplenic tgammadelta cell lymphoma  or primary cutaneous t cell lymphoma pctcl
In the detection of haematological malignancy the purpose of detecting γδ T cells is to define particular T cell lymphomas, since αβ T cells strongly predominate in blood. Some care must be taken when small populations of γδ T cells are detected however, since these may arise in response to viral or other immune responses.
 
TCR analysis is not generally helpful in indicating T-cell clonality since around 95% express of circulating T cells express αβ chains; the remaining 5% of T cells have gamma γδ. in tissues this can be different since the γδ T cells are more abundant in skin and intraepithelial areas. The receptors also reflect different functions:  αβ T cells behave as elements of the adaptive immune system while γδ cells have an innate immune function similar to NK cells.  
 
*A predominant population of γδ T cells circulate may indicate a clonal proliferation most commonly will be hepatosplenic gamma-delta T-cell lymphoma  or primary cutaneous t cell lymphoma (PTCL)

Revision as of 11:44, 14 May 2023

In the detection of haematological malignancy the purpose of detecting γδ T cells is to define particular T cell lymphomas, since αβ T cells strongly predominate in blood. Some care must be taken when small populations of γδ T cells are detected however, since these may arise in response to viral or other immune responses.

TCR analysis is not generally helpful in indicating T-cell clonality since around 95% express of circulating T cells express αβ chains; the remaining 5% of T cells have gamma γδ. in tissues this can be different since the γδ T cells are more abundant in skin and intraepithelial areas. The receptors also reflect different functions: αβ T cells behave as elements of the adaptive immune system while γδ cells have an innate immune function similar to NK cells.

  • A predominant population of γδ T cells circulate may indicate a clonal proliferation most commonly will be hepatosplenic gamma-delta T-cell lymphoma or primary cutaneous t cell lymphoma (PTCL)
Retrieved from ‘https://haematologyetc.co.uk/index.php?title=Extra&oldid=1303’