Extra

TCRgamma delta', ' the primary purpose of using TCR chain analysis is to detect the rare T gamma delta cells that define particular t cell lymphomas. since alpha beta chains strongly predominate in blood testing is not generally helpful in indicating T-cell clonality each TCR comprises the complex of the CD3 molecules with two different protein chains. circulating human T cells in most cases around 95% express alpha beta chains; the remaining 5% of T cells have gamma delta chains. in tissues this can be different since the gamma delat T cells are more abundant in skin and intraepithelial areas. The receptors also reflect different function while alpha beta T cells behave as elements of the adaptive immune system gamma delta-t cells have an innate immune function similar to NK cells . *where predominantly gamma delta-t cells circulate this is an indicator of a clonal proliferation *precise disease type requires confirmation but most commonly will be hepatosplenic tgammadelta cell lymphoma or primary cutaneous t cell lymphoma pctcl