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:CD23 is a broadly expressed molecule whose impotance lies in its value in distinguishing between CLL (consistent expression) and MCL (infrequent expression). | |||
:However, CD23 is not CLL-specific, and the marker is also expressed on other haematological and lymphoma cell types. | |||
normal expression and function | normal expression and function | ||
CD23 is | CD23 is low-affinity receptor for ige involved in antigen capture and presentation at membrane. It affects B-cell growth and differentiation and the activation of monocytes. It is expressed on activated B-cells but also platelets eosinophils activated macrophages and follicular dendritic cells. | ||
other relevant information | |||
CD23 is not CLL-specific; it may be expressed in lymphoplasmacytic lymphoma, marginal zone lymphoma or follicular lymphoma. When CD23 is expressed by MCL the cases may have a more indolent course and an improved outcome. | |||
diagnostic role | diagnostic role | ||
*CD23 is most frequently used | *CD23 is most frequently used to distinguish between CLL and MCL but this difference is not absolute: CD23 is expressed by the vast majority (90% of typical CLL patients), and is generally absent in MCL although it is detected in around 10% of cases where its expression may be bright. | ||
*CD23 may also be expressed by other | *CD23 may also be expressed by other B-lymphoproliferative disorders although at lower frequency. | ||
summary tables | summary tables | ||
Revision as of 15:47, 12 May 2023
- CD23 is a broadly expressed molecule whose impotance lies in its value in distinguishing between CLL (consistent expression) and MCL (infrequent expression).
- However, CD23 is not CLL-specific, and the marker is also expressed on other haematological and lymphoma cell types.
normal expression and function
CD23 is low-affinity receptor for ige involved in antigen capture and presentation at membrane. It affects B-cell growth and differentiation and the activation of monocytes. It is expressed on activated B-cells but also platelets eosinophils activated macrophages and follicular dendritic cells.
other relevant information
CD23 is not CLL-specific; it may be expressed in lymphoplasmacytic lymphoma, marginal zone lymphoma or follicular lymphoma. When CD23 is expressed by MCL the cases may have a more indolent course and an improved outcome.
diagnostic role
- CD23 is most frequently used to distinguish between CLL and MCL but this difference is not absolute: CD23 is expressed by the vast majority (90% of typical CLL patients), and is generally absent in MCL although it is detected in around 10% of cases where its expression may be bright.
- CD23 may also be expressed by other B-lymphoproliferative disorders although at lower frequency.
summary tables
1. expression by acute leukaemias and by haematogones file rareu82epng pro-b all link flow cytometry key file rareu82epng early pre-b all link flow cytometry key file rareu82epng pre-b all link flow cytometry key file rareu82epng early b all link flow cytometry key file rareu82epng pro-t all link flow cytometry key file rareu82epng mature-t all link flow cytometry key file possu82epng aml link flow cytometry key file rareu82epng haemato-gones link flow cytometry key *may be expressed in aml with monocytic differentiation
2. expression by b-lymphoproliferative disorders file hiu82epng frame cll link flow cytometry key file rareu82epng pll link flow cytometry key file possu82epng mcl link flow cytometry key file modu82epng fl link flow cytometry key file possu82epng hcl link flow cytometry key file possu82epng hclv link flow cytometry key file rareu82epng mzl link flow cytometry key file rareu82epng lpl link flow cytometry key file rareu82epng pcs link flow cytometry